Dynamic retinal vessel response to flicker in obesity: A methodological approach

Microvascular Research

Volumn 81, Issue 1, 2011, Pages 123-128

  Kotliar, Konstantin E ^a   Lanzl, Ines M ^a   Schmidt Trucksäss, Arno ^b   Sitnikova, Diana ^a   Ali, Mohammad ^a   Blume, Katharina ^a   Halle, Martin ^a   Hanssen, Henner ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Flicker stimulation; Microcirculation; Obesity; Retinal vessel reactivity

Indexed keywords

ADULT; ARTERIOLE; ARTICLE; BLOOD VESSEL DIAMETER; BODY MASS; CLINICAL ARTICLE; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; DYNAMIC RETINAL VESSEL ANALYSIS; FEMALE; HUMAN; MALE; MICROANGIOPATHY; NON INVASIVE MEASUREMENT; OBESITY; PRIORITY JOURNAL; RETINA BLOOD VESSEL; VASODILATATION; WAIST CIRCUMFERENCE;

ADULT; ARTERIOLES; BLOOD PRESSURE; BODY MASS INDEX; FEMALE; HUMANS; LIGHT; MALE; MIDDLE AGED; OBESITY; PHOTIC STIMULATION; RETINAL ARTERY; RETINAL VEIN; RETINAL VESSELS; VASODILATION; VENULES; WAIST CIRCUMFERENCE;

EID: 78650766515     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2010.11.007     Document Type: Article

References (34)

1. Adams K.F., et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71years old. N. Engl. J. Med. 2006, 355:763-778.
2. Anon, et al. Hypertension in Diabetes Study (HDS): II. Increased risk of cardiovascular complications in hypertensive type 2 diabetic patients. J. Hypertens. 1993, 11:319-325.
3. Dorner G.T., et al. Nitric oxide regulates retinal vascular tone in humans. Am. J. Physiol. Heart Circ. Physiol. 2003, 285:H631-H636.
4. Falsini B., et al. Neuro-vascular coupling in the human inner retina. Ophthalmic Res. 2002, 32(Suppl 1):S133.
5. Garhofer G., et al. Use of the retinal vessel analyzer in ocular blood flow research. Acta Ophthalmol. 2009, Aug 14 (E-pub ahead of print).
6. Gugleta K., et al. Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity. Investig. Ophthalmol. Vis. Sci. 2006, 47:4034-4041.
7. Hubbard L.D., et al. Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology 1999, 106:2269-2280.
8. Ikram M.K., et al. Retinal vessel diameters and risk of stroke: the Rotterdam Study. Neurology 2006, 66:1339-1343.
9. Katzmarzyk P.T., et al. Physical inactivity, excess adiposity and premature mortality. Obes. Rev. 2003, 4:257-290.
10. Klein B.E., et al. Intraocular pressure in an American community. The Beaver Dam Eye Study. Investig. Ophthalmol. Vis. Sci. 1992, 33:2224-2228.
11. Kneser M., et al. Age related decline of microvascular regulation measured in healthy individuals by retinal dynamic vessel analysis. Med. Sci. Monit. 2009, 15. CR436-41.
12. Kotliar K.E., et al. Retinal vessel reaction in response to chromatic flickering light. Graefes Arch. Clin. Exp. Ophthalmol. 2004, 242:377-392.
13. Lanzl I.M., et al. Age Dependence of Retinal Vessel Reaction to Flicker. Investig. Ophthalmol. Vis. Sci. 2007, 48(Suppl). E:2263.
14. Lanzl I.M., et al. Dynamic retinal vessel response to flicker in age-related macular degeneration patients before and after vascular endothelial growth factor inhibitor injection. Acta Ophthalmol. 2010, Jan 22. [Epub ahead of print].
15. Mandecka A., et al. Influence of flickering light on the retinal vessels in diabetic patients. Diab. Care 2007, 30:3048-3052.
16. Mandecka A., et al. Abnormal retinal autoregulation is detected by provoked stimulation with flicker light in well-controlled patients with type 1 diabetes without retinopathy. Diab. Res. Clin. Pract. 2009, 86:51-55.
17. Mori K., et al. Relationship between intraocular pressure and obesity in Japan. Int. J. Epidemiol. 2000, 29:661-666.
18. Nagel E., et al. Age, blood pressure, and vessel diameter as factors influencing the arterial retinal flicker response. Investig. Ophthalmol. Vis. Sci. 2004, 45:1486-1492.
19. Nguyen T.T., Wong T.Y. Retinal vascular manifestations of metabolic disorders. Trends Endocrinol. Metab. 2006, 17:262-268.
20. Nguyen T.T., et al. Flicker-light induced retinal vasodilation in diabetes and diabetic retinopathy. Diab. Care 2009, 32:2075-2080.
21. Pischon T., et al. General and abdominal adiposity and risk of death in Europe. N. Engl. J. Med. 2008, 359:2105-2120.
22. Polak K., et al. Influence of flicker frequency on flicker-induced changes of retinal vessel diameter. Investig. Ophthalmol. Vis. Sci. 2002, 43:2721-2726.
23. Rossing P., et al. Predictors of mortality in insulin dependent diabetes: 10year observational follow up study. BMJ 1996, 313:779-784.
24. Schiel R., et al. Retinal vessel response to flicker light in children and adolescents with type 1 diabetes mellitus and overweight or obesity. Diab. Res. Clin. Pract. 2009, 83:358-364.
25. Seidova S.-F., et al. Dynamic retinal vessel reaction in patients with primary open angle glaucoma. Acta Ophthalmol. Scand. 2007, 85(Suppl 239):55.
26. Seifert B.U., Vilser W. Retinal Vessel Analyzer (RVA)-design and function. Biomed Tech (Berl) 2002, 47(Suppl 1 Pt 2):678-681.
27. Sitnikova D., et al. Dynamic retinal vessel reaction in patients with diabetes mellitus type 1. Investig. Ophthalmol. Vis. Sci. 2008, 49(Suppl). E:2738.
28. Vilser W., et al. Retinal vessel analysis-new possibilities. Biomed Tech (Berl) 2002, 47(Suppl 1 Pt 2):682-685.
29. Wang J.J., et al. Retinal vessel diameters and obesity: a population-based study in older persons. Obesity (Silver Spring). 2006, 14:206-214.
30. Wannamethee S.G., et al. Overweight and obesity and weight change in middle aged men: impact on cardiovascular disease and diabetes. J. Epidemiol. Community Health 2005, 59:134-139.
31. Wong T.Y., et al. Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities study. Lancet 2001, 358:1134-1140.
32. Wong T.Y., et al. Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study. JAMA 2002, 287:1153-1159.
33. Wong T.Y., et al. Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk In Communities study. Investig. Ophthalmol. Vis. Sci. 2004, 45:2949-2954.
34. Wu S.Y., Leske M.C. Associations with intraocular pressure in the Barbados Eye Study. Arch. Ophthalmol. 1997, 115:1572-1576.