Investigation of the mechanical properties and porosity relationships in selective laser-sintered polyhedral for functionally graded scaffolds

Acta Biomaterialia

Volumn 7, Issue 2, 2011, Pages 530-537

  Sudarmadji, N ^a   Tan, J Y ^a   Leong, K F ^a   Chua, C K ^a   Loh, Y T ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Bone tissue engineering; Computer aided tissue engineering; Functionally graded scaffolds; Mechanical properties; Rapid prototyping

Indexed keywords

BONE; COMPUTER AIDED DESIGN; LASER HEATING; POLYCAPROLACTONE; POROSITY; RAPID PROTOTYPING; SCAFFOLDS (BIOLOGY); SINTERING; STIFFNESS;

BONE TISSUE ENGINEERING; COMPRESSIVE STIFFNESS; COMPUTER-AIDED TISSUE ENGINEERING; DESIGN-PROCESS; FUNCTIONALLY GRADED; FUNCTIONALLY GRADED SCAFFOLD; RAPID-PROTOTYPING; SCAFFOLD FABRICATION; SCAFFOLD POROSITY; TISSUE ENGINEERING SCAFFOLD;

BIOMECHANICS;

POLYCAPROLACTONE; TISSUE SCAFFOLD;

ARTICLE; AUTOMATION; COMPRESSIVE STRENGTH; COMPUTER AIDED DESIGN; CYTOTOXICITY; DATA BASE; MATHEMATICAL ANALYSIS; MOLECULAR MECHANICS; POROSITY; PRIORITY JOURNAL; STRESS STRAIN RELATIONSHIP; STRUCTURE ANALYSIS; TOXICITY TESTING;

EID: 78650720318     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2010.09.024     Document Type: Article

References (33)

1. S.F. Yang The design of scaffolds for use in tissue engineering. Part I. Traditional factors Tissue Eng 7 6 2001 679 689
2. P.X. Ma Scaffolds for tissue fabrication Mater Today 7 5 2004 30 40
3. J.R. Porter, T.T. Ruckh, and K.C. Popat Bone tissue engineering: a review in bone biomimetics and drug delivery strategies Biotechnol Progr 25 6 2009 1539 1560
4. H. Petite Tissue-engineered bone regeneration Nat Biotechnol 18 9 2000 959 963
5. Vang P. Advantages and disadvantages between allograft versus autograft in anterior cruciate ligament replacement. PhD Thesis, Wichita State University, Wichita, KS; 2006. p. 22.
6. J.J. Marler Transplantation of cells in matrices for tissue regeneration Adv Drug Deliv Rev 33 1/2 1998 165 182
7. K.F. Leong Engineering functionally graded tissue engineering scaffolds J Mech Behav Biomed Mater 1 2 2008 140 152
8. R.G. Ford, Y. Miyamoto, and F. Nogata Lessons from nature Y. Miyamoto, Functionally graded materials: design, processing and applications 1999 Kluwer Academic Boston, MA 7 28
9. Chua CK, Sudarmadji N, Leong KF. Functionally graded scaffolds: the challenges in design and fabrication methods. In: 3rd International Conference on Advanced Research in Virtual and Rapid Prototyping, Leiria, Portugal. London, UK: Taylor & Francis Group; 2007.
10. V. Karageorgiou, and D. Kaplan Porosity of 3D biomaterial scaffolds and osteogenesis Biomaterials 26 27 2005 5474 5491
11. D.W. Hutmacher, M. Sittinger, and M.V. Risbud Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems Trends Biotechnol 22 7 2004 354 362
12. C.K. Chua Development of a tissue engineering scaffold structure library for rapid prototyping. Part 1: Investigation and classification Int J Adv Manuf Technol 21 4 2003 291 301
13. C.K. Chua Development of a tissue engineering scaffold structure library for rapid prototyping. Part 2: Parametric library and assembly program Int J Adv Manuf Technol 21 4 2003 302 312
14. M.W. Naing Fabrication of customised scaffolds using computer-aided design and rapid prototyping techniques Rapid Prototyping J 11 4 2005 249 259
15. C.M. Cheah Automatic algorithm for generating complex polyhedral scaffold structures for tissue engineering Tissue Eng 10 3/4 2004 595 610
16. I. Engelberg, and J. Kohn Physico-mechanical properties of degradable polymers used in medical applications: a comparative study Biomaterials 12 3 1991 292 304
17. M. Hakkarainen, and A.C. Albertsson Heterogeneous biodegradation of polycaprolactone - low molecular weight products and surface changes Macromol Chem Phys 203 10/11 2002 1357 1363
18. G. Ciapetti Osteoblast growth and function in porous poly - caprolactone matrices for bone repair: a preliminary study Biomaterials 24 21 2003 3815 3824
19. K.C. Ang Compressive properties and degradability of poly(-caprolatone)/ hydroxyapatite composites under accelerated hydrolytic degradation J Biomed Mater Res 80A 3 2007 655 660
20. Sudarmadji N, et al. Compact adaptation device for selective laser sintering of tissue engineering scaffolds. In: The 7th International Conference on Materials Processing for Properties and Performance, Singapore; 2008.
21. F.E. Wiria Selective laser sintering adaptation tools for cost effective fabrication of biomedical prototypes Rapid Prototyping J 16 2 2010 90 99
22. K.H. Tan Selective laser sintering of biocompatible polymers for applications in tissue engineering Bio-Med Mater Eng 15 1/2 2005 113 124
23. ASTM International. ASTM D 1621-04a, Standard Test Method for Compressive Properties of Rigid Cellular Plastics. West Conshohocken, PA: ASTM International.
24. K.F. Leong Building porous biopolymeric microstructures for controlled drug delivery devices using selective laser sintering Int J Adv Manuf Technol 31 5 2006 483 489
25. D. Hull An Introduction to Composite Materials 2nd ed. 1996 Cambridge University Press Cambridge
26. B. Madsen, and H. Lilholt Physical and mechanical properties of unidirectional plant fibre composites - an evaluation of the influence of porosity Compos Sci Technol 63 9 2003 1265 1272
27. B. Madsen, A. Thygesen, and H. Lilholt Plant fibre composites - porosity and stiffness Compos Sci Technol 69 7/8 2009 1057 1069
28. L.C. Wang Synthesis and evaluation of biodegradable segmented multiblock poly(ether ester) copolymers for biomaterial applications Polym Int 53 12 2004 2145 2154
29. L.J. Gibson, and M.F. Ashby D.R. Clarke, S. Suresh, I. MW, Cellular solids structure and properties 2nd ed. 1997 Cambridge University Press Cambridge, UK 510
30. A. Woesz, J. Stampfl, and P. Fratzl Cellular solids beyond the apparent density - an experimental assessment of mechanical properties Adv Eng Mater 6 3 2004 134 138
31. W.Y. Zhou Selective laser sintering of porous tissue engineering scaffolds from poly(l-lactide)/carbonated hydroxyapatite nanocomposite microspheres J Mater Sci: Mater Med 19 7 2008 2535 2540
32. C.E. Misch, Z. Qu, and M.W. Bidez Mechanical properties of trabecular bone in the human mandible: implications for dental implant treatment planning and surgical placement J Oral Maxillofac Surg 57 1999 700 706
33. Chua CK, et al. Process flow for designing functionally graded tissue engineering scaffolds. In: 4th International Conference on Advanced Research in Virtual and Rapid Prototyping, Leiria, Portugal. London, UK: Taylor & Francis Group; 2009. p. 45-9.