Association of novel mutations and heplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma

Frontiers of Medicine in China

Volumn 4, Issue 4, 2010, Pages 419-429

  Xie, Jia Xin ^a   Zhao, Jun ^a   Yin, Jian Hua ^a   Zhang, Qi ^a   Pu, Rui ^a   Lu, Wen Ying ^a   Zhang, Hong Wei ^a   Wang, Hong Yang ^a   Cao, Guang Wen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

genotype; haplotype; hepatitis B virus; hepatocellular carcinoma; mutation

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; PRESURFACE PROTEIN 1, HEPATITIS B SURFACE ANTIGEN; PRESURFACE PROTEIN 2, HEPATITIS B SURFACE ANTIGEN; PROTEIN PRECURSOR; S ENVELOPE PROTEIN, HEPATITIS B VIRUS; VIRUS ENVELOPE PROTEIN;

ARTICLE; GENETICS; GENOTYPE; HAPLOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; MOLECULAR GENETICS; MULTIVARIATE ANALYSIS; MUTATION; PATHOPHYSIOLOGY; RISK FACTOR; VIROLOGY;

CARCINOMA, HEPATOCELLULAR; GENOTYPE; HAPLOTYPES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; MULTIVARIATE ANALYSIS; MUTATION; PROTEIN PRECURSORS; RISK FACTORS; VIRAL ENVELOPE PROTEINS;

EID: 78650689654     PISSN: 16737342     EISSN: 16737458     Source Type: Journal    
DOI: 10.1007/s11684-010-0160-0     Document Type: Article

References (21)

1. Nguyen V T, Law M G, Dore G J. Hepatitis B-related hepatocellular carcinoma: epidemiological characteristics and disease burden. J Viral Hepat, 2009, 16(7): 453-463.
2. El-Serag H B, Rudolph K L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 2007, 132(7): 2557-2576.
3. Yin J, Zhang H, Li C, Gao C, He Y, Zhai Y, Zhang P, Xu L, Tan X, Chen J, Cheng S, Schaefer S, Cao G. Role of hepatitis B virus genotype mixture, subgenotypes C2 and B2 on hepatocellular carcinoma: compared with chronic hepatitis B and asymptomatic carrier state in the same area. Carcinogenesis, 2008, 29(9): 1685-1691.
4. Liu S, Zhang H, Gu C, Yin J, He Y, Xie J, Cao G. Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis. J Natl Cancer Inst, 2009, 101(15): 1066-1082.
5. Cao G W. Clinical relevance and public health significance of hepatitis B virus genomic variations. World J Gastroenterol, 2009, 15(46): 5761-5769.
6. Yin J, Zhang H, He Y, Xie J, Liu S, Chang W, Tan X, Gu C, Lu W, Wang H, Bi S, Cui F, Liang X, Schaefer S, Cao G. Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study. Cancer Epidemiol Biomarkers Prev, 2010, 19(3): 777-786.
7. Kay A, Zoulim F. Hepatitis B virus genetic variability and evolution. Virus Res, 2007, 127(2): 164-176.
8. Chen B F, Liu C J, Jow G M, Chen P J, Kao J H, Chen D S. High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. Gastroenterology, 2006, 130(4): 1153-1168.
9. Gao Z Y, Li T, Wang J, Du J M, Li Y J, Li J, Lu F M, Zhuang H. Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma. J Gastroenterol, 2007, 42(9): 761-768.
10. Cao Z, Bai X, Guo X, Jin Y, Qian G, Tu H. High prevalence of hepatitis B virus pre-S mutation and its association with hepatocellular carcinoma in Qidong, China. Arch Virol, 2008, 153(10): 1807-1812.
11. Fang Z L, Sabin C A, Dong B Q, Wei S C, Chen Q Y, Fang K X, Yang J Y, Huang J, Wang X Y, Harrison T J. Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case-control study. J Gen Virol, 2008, 89(Pt 11): 2882-2890.
12. Yin J, Xie J, Zhang H, Shen Q, Han L, Lu W, Han Y, Li C, Ni W, Wang H, Cao G. Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma. J Gastroenterol, 2010, 45(10): 1063-1071.
13. Chen J, Yin J, Tan X, Zhang H, Zhang H, Chen B, Chang W, Schaefer S, Cao G. Improved multiplex-PCR to identify hepatitis B virus genotypes A-F and subgenotypes B1, B2, C1 and C2. J Clin Virol, 2007, 38(3): 238-243.
14. Zhang H W, Yin J H, Li Y T, Li C Z, Ren H, Gu C Y, Wu H Y, Liang X S, Zhang P, Zhao J F, Tan X J, Lu W, Schaefer S, Cao G W. Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China. Gut, 2008, 57(12): 1713-1720.
15. Shen T, Yan X M, Zou Y L, Gao J M, Dong H. Virologic characteristics of hepatitis B virus in patients infected via maternalfetal transmission. World J Gastroenterol, 2008, 14(37): 5674-5682.
16. Bock C T, Tillmann H L, Maschek H J, Manns M P, Trautwein C. A preS mutation isolated from a patient with chronic hepatitis B infection leads to virus retention and misassembly. Gastroenterology, 1997, 113(6): 1976-1982.
17. Hsieh Y H, Su I J, Wang H C, Chang W W, Lei H Y, Lai M D, Chang W T, Huang W. Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis, 2004, 25(10): 2023-2032.
18. Kekulé A S, Lauer U, Meyer M, Caselmann W H, Hofschneider P H, Koshy R. The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature, 1990, 343(6257): 457-461.
19. Göbel F, Taschner S, Jurkin J, Konradi S, Vaculik C, Richter S, Kneidinger D, Mühlbacher C, Bieglmayer C, Elbe-Bürger A, Strobl H. Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation. Blood, 2009, 114(18): 3813-3821.
20. Andrieux L O, Fautrel A, Bessard A, Guillouzo A, Baffet G, Langouët S. GATA-1 is essential in EGF-mediated induction of nucleotide excision repair activity and ERCC1 expression through ERK2 in human hepatoma cells. Cancer Res, 2007, 67(5): 2114-2123.
21. Banerjee R, Caruccio L, Zhang Y J, McKercher S, Santella R M. Effects of carcinogen-induced transcription factors on the activation of hepatitis B virus expression in human hepatoblastoma HepG2 cells and its implication on hepatocellular carcinomas. Hepatology, 2000, 32(2): 367-374.