Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice

Journal of Ethnopharmacology

Volumn 133, Issue 1, 2011, Pages 164-167

  Arrau, Sylvia ^a   Delporte, Carla ^a   Cartagena, Carlos ^a   Rodríguez Díaz, Maité ^a   González, Patricia ^b   Silva, Ximena ^b   Cassels, Bruce K ^a   Miranda, Hugo F ^c  

^a UNIVERSITY OF CHILE   (Chile)

^b INSTITUTO DE SALUD PÚBLICA DE CHILE   (Chile)

^c UNIVERSITY OF CHILE   (Chile)

Author keywords

Analgesic activity; Hot plate assay; Quillaic acid; Quillaic acid derivatives; Quillaja saponaria; Tail flick assay

Indexed keywords

IBUPROFEN; METHYL 3BETA,16ALPHA DIHYDROXY 23 OXOOLEAN 12 EN 28 OATE; METHYL 4 NOR 3,16 DIOXOOLEAN 12 EN 28 OATE; QUILLAIC ACID; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BARK; CHILE; CONTROLLED STUDY; DOSE RESPONSE; HOT PLATE TEST; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; QUILLAJA SAPONARIA; TAIL FLICK TEST; TRADITIONAL MEDICINE;

ANALGESICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; OLEANOLIC ACID; PAIN; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; QUILLAJA; SAPONINS; TRITERPENES;

MURINAE; MUS; QUILLAJA SAPONARIA;

EID: 78650678997     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.09.016     Document Type: Article

References (19)

1. N. Backhouse, C. Delporte, C. Apablaza, M. Farías, L. Goïty, S. Arrau, R. Negrete, C. Castro, and H.F. Miranda Antinociceptive activity of Buddleja globosa (Matico) in several models of pain Journal of Ethnopharmacology 119 2008 160 165
2. A. Buvanendran, and J.S. Kroin Multimodal analgesia for controlling acute postoperative pain Current opinion in Anesthesiology 22 2009 588 593
3. J. Choi, K. Huh, S.H. Kim, K.T. Lee, H.J. Park, and Y.N. Han Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals Journal of Ethnopharmacology 79 2002 199 204
4. J. Choi, H.J. Jung, K.T. Lee, H.J. Park, M.A. Lacaille-Dubois, and H. Wagner A review of the biological and pharmacological activities of saponins Journal of Medical Food 8 2005 78 85
5. C. Delporte, N. Backhouse, V. Inostroza, M.C. Aguirre, N. Peredo, X. Silva, R. Negrete, and H.F. Miranda Analgesic activity of Ugni molinae (murtilla) in mice models of acute pain Journal of Ethnopharmacolology 112 2007 162 165
6. A. Dogrul, S.E. Gülmez, S. Deveci, H. Gul, M.H. Ossipov, F. Porreca, and C. Tulunay The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test Anesthesiology and Analgesy 104 2007 927 935
7. G. Francis, Z. Kerem, H.P.S. Makkar, and K. Becker The biological action of saponins in animal systems: a review British Journal of Nutrition 88 2002 587 605
8. M.R.S. Greice, V.M. Gadotti, L.C. Meffi, G.S. Silva, M.S. Azevedo, and A.D.R.S. Santos Antinocicecptive and anti-inflammatory properties from the bulbs of Cipura paludosa Journal of Ethnopharmacology 112 2007 19 25
9. M.R. Heidari, M. Mehrabani, A. Pardakhty, P. Khazaeli, M.J. Zahedi, M. Yakhchali, and M. Vahedian The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments Annals of the New York Academy of Sciences 1095 2007 418 427
10. K. Hostettmann, and A. Marston Saponins 1995 Cambridge University Press Cambridge, New York
11. T.R. Lavich, R.S.B. Cordeiro, P.M.R. Silva, and M.A. Martins A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics Brazilian Journal of Medical and Biological Research 38 2005 445 451
12. M.A. Lacaille-Dubois, and H. Wagner A review of the biological and pharmacological activities of saponins Phytomedicine 2 1996 363 386
13. D. Le Bars, M. Gozariu, and S.W. Cadden Animal models of nociception Pharmacology Review 53 2001 597 652
14. H.F. Miranda, M.M. Puig, J.C. Prieto, and Pinardig Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain Pain 121 2006 22 28
15. L. Menéndez, F. Andrés-Trelles, A. Hidalgo, and A. Bahamonde Involvement of spinal k opioid receptors in a type of footshock-induced analgesia in mice Brain Research 611 1993 264 271 (Pubitemid 23159694)
16. J. Milgate, and D.C.K. Roberts The nutritional and biological significance of saponins Nutritional Research 15 1995 1223 1249
17. S. Rinaldi, D.O. Silva, F. Bello, C.S. Alviano, D.S. Alviano, M.E. Metheus, and P.D. Fernández Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models Journal of Ethnopharmacology 122 2009 541 546
18. M.R Roner, J. Sprayberry, M. Spinks, and S. Dhanji Antiviral activity obtained from aqueous extracts of the Chilean soap bark tree (Quillaja saponaria Mol.) Journal of Genetic Virology 88 2007 275 285
19. Zin, J., Weiss, C., 1980. La salud por medio de las plantas medicinales. Edit. Salesiana.6 Ed. p 277.