Challenges in the development of hydrate phases as active pharmaceutical ingredients - An example

European Journal of Pharmaceutical Sciences

Volumn 42, Issue 1-2, 2011, Pages 116-129

  Feth, Martin P ^a   Nagel, Norbert ^a   Baumgartner, Bruno ^a   Bröckelmann, Martin ^a   Rigal, David ^a   Otto, Bernhard ^a   Spitzenberg, Michael ^a   Schulz, Markus ^a   Becker, Bernd ^a   Fischer, Franceska ^a   Petzoldt, Christine ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

Crystallization; Drying; Hydrates; Micronization; Phase transformations; Sieving

Indexed keywords

4 ( 4 [ 3 ( 5 FLUORO 3,4 DIHYDROXY 6 HYDROXYMETHYLTETRAHYDROPYRAN 2 YLOXY) 5 ISOPROPYL 1H PYRAZOL 4 YLMETHYL]PHENYL) N [ 2 HYDROXY 1,1 BIS(HYDROXYMETHYL)ETHYL]BUTYRAMIDE; SAR 474832; TETRAHYDROPYRAN DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG FORMULATION; DRUG INDUSTRY; DRUG SOLUBILITY; HYDRATION; ISOLATION AND PURIFICATION; NEEDLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; PHASE TRANSITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SOLID STATE; STOICHIOMETRY; X RAY DIFFRACTION;

CRYSTALLIZATION; EXCIPIENTS; GLUCOSIDES; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; PHASE TRANSITION; PILOT PROJECTS; POWDERS; PYRAZOLES; SOLUBILITY; SPECTRUM ANALYSIS, RAMAN; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL; WATER; X-RAY DIFFRACTION;

EID: 78650677446     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.11.001     Document Type: Article

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