Manipulating hydrate formation during high shear wet granulation using polymeric excipients

Journal of Pharmaceutical Sciences

Volumn 98, Issue 12, 2009, Pages 4670-4683

  Gift, Alan D ^a   Luner, Paul E ^b   Luedeman, Laura ^c   Taylor, Lynne S ^c  

^a UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^b PFIZER INC   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Crystal; Excipients; Hydrate; Inhibition; Nucleation; Polymers; Raman spectroscopy; Solution mediated transformation; Wet granulation

Indexed keywords

CAFFEINE; CARBAMAZEPINE; CARBOMER; CARBOXYMETHYLCELLULOSE; EXCIPIENT; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; METHYLCELLULOSE; MICROCRYSTALLINE CELLULOSE; POLYVINYL ALCOHOL; POVIDONE; SULFAGUANIDINE; WATER;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; DRUG FORMULATION; DRUG GRANULATION; DRUG SOLUBILITY; DRUG STRUCTURE; HYDRATION; PARTICLE SIZE; RAMAN SPECTROMETRY; SHEAR FLOW; SHEAR RATE; SHEAR STRESS; WATER ABSORPTION;

EID: 71649102101     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21763     Document Type: Article

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