Effects of food and gender on the pharmacokinetics of rhein and emodin in rats after oral dosing with Da-Cheng-Qi decoction

Phytotherapy Research

Volumn 25, Issue 1, 2011, Pages 74-80

  Gong, Han Lin ^a   Tang, Wen Fu ^a   Wang, Hong ^a   Xia, Qing ^a   Huang, Xi ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Da Cheng Qi decoction; emodin; HPLC; pharmacokinetics; rhein; traditional Chinese medicine

Indexed keywords

EMODIN; RHEIN;

ANIMAL EXPERIMENT; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DA CHENG QI DECOCTION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; SEX DIFFERENCE;

ANIMALS; ANTHRAQUINONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; EATING; EMODIN; FEMALE; HALF-LIFE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS;

CITRUS AURANTIUM; MAGNOLIA OFFICINALIS; MAGNOLIACEAE; POLYGONACEAE; RATTUS; RHEUM OFFICINALE; RUTACEAE;

EID: 78650673295     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3223     Document Type: Article

References (15)

1. Bent SR, Ko A., 2004. Commonly used herbal medicines in the United States: a review. Am J Med 116: 478-485.
2. Drasar P, Moravcova J., 2004. Recent advances in analysis of Chinese medical plants and traditional medicines. J Chromatogr B Analyt Technol Biomed Life Sci 812: 3-21.
3. Fleisher D, Li C, Zhou Y, Pao LH, Karim A., 1999. Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications. Clin Pharmacokinet 36: 233-254.
4. Katakai M, Akamaru T, Tani T., 2002. An analysis of the frequency of formulations and crude drugs described in Shan-Han-Lun. Yakushigaku Zasshi 37: 28-35.
5. Lee JH, Kim JM, Kim C., 2003. Pharmacokinetic analysis of rhein in Rheum undulatum L. J Ethnopharmacol 84: 5-9.
6. Li G, Xiao XH, Jin C, Li ZL., 2007. Adverse effect of Radix et Rhizoma Rhei in ancient and modern times. China J Tradit Chin Med Pharm 22: 439-442.
7. Liu XB, Jiang JM, Huang ZW, et al,. 2004. Clinical study on the treatment of severe acute pancreatitis by integrated traditional Chinese medicine and Western medicine. Sichuan Da Xue Xue Bao Yi Xue Ban 35: 204-208.
8. Singh BN, Malhotra BK., 2004. Effects of food on the clinical pharmacokinetics of anticancer agents. Clin Pharmacokinet 43: 1127-1156.
9. Tang WF, Huang X, Yu Q, et al,. 2007. Determination and pharmacokinetic comparison of rhein in rats after oral dose with Da-Cheng-Qi Decoction and Xiao-Cheng-Qi decoction. Biomed Chromatogr 21: 1186-1190.
10. Tang WF, Wan MH, Zhu L, Chen GY, Xia Q, Huang X., 2005. Immunomodulatory effect of somatostatin combined with traditional Chinese medicine on severe acute pancreatitis at early stage: a randomized control trial. Zhong Xi Yi Jie He Xue Bao 3: 103-107.
11. Welling PG., 1996. Effects of food on drug absorption. Annu Rev Nutr 16: 383-415.
12. Xia Q, Huang ZW, Jiang JM, Chen GY, Yang XN, Tang WF., 2006. 'Yi-Huo-Qing-Xia' method as the main therapy in integrated traditional Chinese and Western medicine on severe acute pancreatitis: a report of 1161 cases. Chin J Integr Tradit Western Med Intens Crit Care 13: 31-134.
13. Xia Q, Yuan L, Yang XN, Tang WF, Jiang JM., 2005. Comparison of integrated Chinese and Western medicine with and without somatostatin supplement in the treatment of severe acute pancreatitis. World J Gastroenterol 11: 1073-1076.
14. Zhang ZJ., 2005. Shanghanlun. People's Medical Publishing House, Beijing: 8.
15. Zhu W, Ruan XM, Chen KJ., 2006. Effect of gender difference on pharmacokinetics of rhein in healthy volunteers after oral administration of rhubarb extract. Chin J Clin Pharmacol Ther 11: 223-226.