Genetic regulatory network analysis for Myoc based on genetical genomics approach

Proceedings - 2010 3rd International Conference on Biomedical Engineering and Informatics, BMEI 2010

Volumn 5, Issue , 2010, Pages 2201-2205

  Lu, Hong ^a   Chen, Hui ^a   Chen, Hao ^b   Lu, Lu ^a   Guan, Huaijin ^a  

^a NANTONG UNIVERSITY   (China)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Expression QTL; Genetic regulatory network; Myoc; Primary open angle glaucoma

Indexed keywords

ARRAY ANALYSIS; COMPLEX TRAITS; EXPRESSION LEVELS; EXPRESSION QTL; GENE ONTOLOGY; GENETIC REGULATORY NETWORKS; GENETICAL GENOMICS; INTERVAL MAPPING; MYOC; MYOCILIN; PARENTAL STRAINS; PRIMARY OPEN-ANGLE GLAUCOMA; QUANTITATIVE TRAIT LOCI MAPPINGS; QUANTITATIVE TRAIT LOCUS; RECOMBINANT INBRED; REGULATORY NETWORK;

BIOMEDICAL ENGINEERING; ELECTRIC NETWORK ANALYSIS; GENES; INFORMATION SCIENCE; MAPPING; ONTOLOGY; PLANTS (BOTANY);

OPHTHALMOLOGY;

EID: 78650661886     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/BMEI.2010.5639531     Document Type: Conference Paper

References (22)

1. H. A. Quigley, and A. T. Broman, "The number of people with glaucoma worldwide in 2010 and 2020," Br J Ophthalmol, vol. 90, no. 3, pp. 262-7, Mar, 2006.
2. M. Feldkamper, and F. Schaeffel, "Interactions of genes and environment in myopia," Dev Ophthalmol, vol. 37, pp. 34-49, 2003.
3. C. A. McCarty, and H. R. Taylor, "Myopia and vision 2020," Am J Ophthalmol, vol. 129, no. 4, pp. 525-7, Apr, 2000.
4. E. M. Stone, J. H. Fingert, W. L. Alward et al., "Identification of a gene that causes primary open angle glaucoma," Science, vol. 275, no. 5300, pp. 668-70, Jan 31, 1997.
5. L. Xu, Y. Wang, S. Wang et al., "High myopia and glaucoma susceptibility the Beijing Eye Study," Ophthalmology, vol. 114, no. 2, pp. 216-20, Feb, 2007.
6. P. Mitchell, F. Hourihan, J. Sandbach et al., "The relationship between glaucoma and myopia: the Blue Mountains Eye Study," Ophthalmology, vol. 106, no. 10, pp. 2010-5, Oct, 1999.
7. A. Karali, P. Russell, F. H. Stefani et al., "Localization of myocilin/trabecular meshwork - inducible glucocorticoid response protein in the human eye," Invest Ophthalmol Vis Sci, vol. 41, no. 3, pp. 729-40, Mar, 2000.
8. R. E. Swiderski, J. L. Ross, J. H. Fingert et al., "Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization," Invest Ophthalmol Vis Sci, vol. 41, no. 11, pp. 3420-8, Oct, 2000.
9. S. I. Tomarev, G. Wistow, V. Raymond et al., "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis," Invest Ophthalmol Vis Sci, vol. 44, no. 6, pp. 2588-96, Jun, 2003.
10. E. R. Tamm, P. Russell, D. L. Epstein et al., "Modulation of myocilin/TIGR expression in human trabecular meshwork," Invest Ophthalmol Vis Sci, vol. 40, no. 11, pp. 2577-82, Oct, 1999.
11. D. M. Peters, K. Herbert, B. Biddick et al., "Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions," Exp Cell Res, vol. 303, no. 2, pp. 218- 28, Feb 15, 2005.
12. X. Shen, T. Koga, B. C. Park et al., "Rho GTPase and cAMP/protein kinase A signaling mediates myocilin-induced alterations in cultured human trabecular meshwork cells," J Biol Chem, vol. 283, no. 1, pp. 603-12, Jan 4, 2008.
13. K. Wentz-Hunter, R. Kubota, X. Shen et al., "Extracellular myocilin affects activity of human trabecular meshwork cells," J Cell Physiol, vol. 200, no. 1, pp. 45-52, Jul, 2004.
14. T. Andrew, N. Maniatis, F. Carbonaro et al., "Identification and replication of three novel myopia common susceptibility gene loci on chromosome 3q26 using linkage and linkage disequilibrium mapping," PLoS Genet, vol. 4, no. 10, pp. e1000220, Oct, 2008.
15. B. Rohrer, J. Tao, and W. K. Stell, "Basic fibroblast growth factor, its high- and low-affinity receptors, and their relationship to formdeprivation myopia in the chick," Neuroscience, vol. 79, no. 3, pp. 775- 87, Aug, 1997.
16. R. C. Jansen, and J. P. Nap, "Genetical genomics: the added value from segregation," Trends Genet, vol. 17, no. 7, pp. 388-91, Jul, 2001.
17. E. J. Chesler, L. Lu, S. Shou et al., "Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function," Nat Genet, vol. 37, no. 3, pp. 233-42, Mar, 2005.
18. E. E. Schadt, S. A. Monks, T. A. Drake et al., "Genetics of gene expression surveyed in maize, mouse and man," Nature, vol. 422, no. 6929, pp. 297-302, Mar 20, 2003.
19. J. L. Peirce, L. Lu, J. Gu et al., "A new set of BXD recombinant inbred lines from advanced intercross populations in mice," BMC Genet, vol. 5, pp. 7, Apr 29, 2004.
20. R. W. Williams, J. Gu, S. Qi et al., "The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis," Genome Biol, vol. 2, no. 11, pp. RESEARCH0046, 2001.
21. B. M. Steiglitz, D. R. Keene, and D. S. Greenspan, "PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1," J Biol Chem, vol. 277, no. 51, pp. 49820-30, Dec 20, 2002.
22. M. C. Embree, T. M. Kilts, M. Ono et al., "Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis," Am J Pathol, vol. 176, no. 2, pp. 812-26, Feb.