New cis-Configured Aziridine-2-carboxylates as Aspartic Acid Protease Inhibitors

ChemMedChem

Volumn 6, Issue 1, 2011, Pages 141-152

  Büchold, Christian ^a   Hemberger, Yasmin ^a   Heindl, Cornelia ^a   Welker, Armin ^a   Degel, Björn ^a   Pfeuffer, Thomas ^a   Staib, Peter ^b   Schneider, Sabrina ^a   Rosenthal, Philip J ^c   Gut, Jiri ^c   Morschhäuser, Joachim ^a   Bringmann, Gerhard ^a   Schirmeister, Tanja ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aspartic acid proteases; Aziridine; Candida albicans; Cathepsin D; Inhibitors

Indexed keywords

ASPARTIC PROTEINASE; ASPARTIC PROTEINASE INHIBITOR; AZIRIDINE; BENZYL 2 [(1 CYCLOHEXYLMETHYL 3 PHENYLAZIRIDINE 2 CARBONYL)AMINO] 3 PHENYLPROPIONATE; BENZYL 2 [(1 TERT BUTYL 3 PHENYLAZIRIDINE 2 CARBONYL)AMINO] 3 PHENYLPROPIONATE; BENZYL 2 [1 ((1,4 DIMETHYLPENTYL) 3 PHENYLAZIRIDINE 2 CARBONYL)AMINO] 3 METHYLBUTANOATE; BENZYL [(2 1 CYCLOHEXYLMETHYL 3 PHENYLAZIRIDINE 2 CARBONYL)AMINO] 3 METHYLBUTANOATE; CARBOXYLIC ACID DERIVATIVE; CATHEPSIN D; CYSTEINE PROTEINASE; ESTER DERIVATIVE; ISOENZYME; NITROGEN; PEPTIDE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; ATOM; CANDIDA ALBICANS; CIRCULAR DICHROISM; DIASTEREOISOMER; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME RELEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; HYDROPHILICITY; IC 50; LIPOPHILICITY; MAMMAL; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; QUANTUM CHEMISTRY; RACEMIC MIXTURE; SYNTHESIS; TITRIMETRY;

ASPARTIC ACID PROTEASES; AZIRIDINES; CANDIDA ALBICANS; CATHEPSIN D; CIRCULAR DICHROISM; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; ISOENZYMES; KINETICS; STEREOISOMERISM;

EID: 78650585096     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000370     Document Type: Article

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