Leydig cell tumour revealed by bilateral gynecomastia in a 15year old adolescent: A patient report

Journal of Pediatric Endocrinology and Metabolism

Volumn 23, Issue 11, 2010, Pages 1195-1199

  Kayemba KaY'S, S ^a   Fromont Hankard, G ^a   Lettelier, G ^a   Gabriel, S ^b   Levard, G ^c  

^a POITIERS UNIVERSITY HOSPITAL   (France)

^b Soyaux Centre Clinical   (France)

^c Centre Hospitalier Universitaire de Pédiatrie   (France)

Author keywords

Adolescent; Gynecomastia; Leydig cell tumour; Puberty; Ultrasonography

Indexed keywords

ESTROGEN; TESTOSTERONE;

ADOLESCENT; ARTICLE; CASE REPORT; GYNECOMASTIA; HUMAN; HUMAN TISSUE; LEYDIG CELL TUMOR; MALE; PUBERTY; SCROTUM; TESTIS; ULTRASOUND;

ADOLESCENT; GYNECOMASTIA; HUMANS; LEYDIG CELL TUMOR; MALE; TESTICULAR NEOPLASMS; TESTIS;

EID: 78650567502     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/jpem.2010.188     Document Type: Article

References (20)

1. Dundar B, Dundar N, Erci T, Bober E, Büyükgebiz A. Leptin levels in boys with pubertal gynecomastia. J Pediatr Endocrinol Metab 2005; 18: 929-34
2. Thomas JC, Ross JH, Kay R. Stromal testis tumors in children: A report from the prepubertal testis tumors registry. J Urol 2001; 166: 2338-2340.
3. Ciftci AO, Bingol-Kologlu M, Senocak ME, Tanyel FC, Buyukpamukcu M, Buyukpamukcu N. Testicular tumors in children. J Pediatr Surg 2001; 36: 1786-1801.
4. Guoquan Liu, Duranteau L, Carel JC, Monroe J, Doyle DA, Shenker A. Leydig cell tumors caused by an activating mutation of the gene encoding the Luteinizing Hormone Receptor. N Engl J Med 1999; 341: 1731-1736.
5. Hendry WS, Garvie WH, Ah-See AK, Bayliss AP. Ultrasonic detection of occult testicular neoplasms in patients with gynecomastia. Br J Radiol 1984; 57: 571-572.
6. Nydick M, Bustos J, Dale JH Jr, Rawson RW. Gynecomastia in adolescent boys. JAMA 1961; 178: 449-454
7. Sher ES, Migeon CJ, Berkovitz GD. Evaluation of boys with marked breast development at puberty. Clin Pediatr 1998; 37: 367-371.
8. Dilworth JP, Farrow GM, Oesterling JE. Non-germ cell tumors of testis. Urology 1991; 37: 399-417.
9. Kim I, Young RH, Scully RE. Leydig cell tumors of the testis: a clinico-pathological analysis of 40 cases and review of the literature. Am J Surg Pathol 1985; 9: 177-192.
10. Rich MA, Keating MA. Leydig cell tumors and tumors associated with congenital adrenal hyperplasia. Urol Clin North Am 2000; 27: 519-528.
11. Giannarini G, Mogorovich A, Menchini Fabris F, Morelli G, De Maria M, Manassero F, Loggini B, Pingitore R, Cavazzana A, Selli C. Long-term follow-up after elective testis sparing surgery for Leydig cell tumors: a single centre experience. J Urol 2007: 178: 872-876.
12. Sacci E. Di un caso di gigantismo infantile (pedomacrosomia) con tumore del testiculo. Riv Sper Freniat Med Leg Alien Ment 1895; 21: 149-161.
13. Kuhn JM, Reznik Y, Mahoudeau JA, Courtois H, Lefebvre H, Wolf LM, Luton JP. hCH test in Gynecomastia: further study. Clin Endocrinol 1989; 31(5): 581-590.
14. Foppiani L, Bernarsconi D, Del Monte P, Marugo A, Toncini C, Marugo M. Leydig cell tumour-induced bilateral gynecomastia in a young man: endocrine abnormalities. Andrologia 2005; 37: 36-39.
15. Nubiola Calonge A, Valladares LC, Jové Vidal N, Pérez Herms S, Palacin Casal JM, Torres Salinas M. Gynecomastia and Leydig cell tumor, clinically occult. Arch Esp Urol. 1996; 49: 763-766.
16. Wasniewska M, Raiola G, Galati MC, Salzano G, Rulli L, Zirilli G, De Luca F. Non-classical 21hydroxylase deficiency in boys with prepubertal or pubertal gynecomastia. Eur J Pediatr 2008; 167:1083-1084.
17. Carmignani L, Colombo R, Gadda F, Galasso G, Lania A, Palou J, Algaba F, Villavicencio H, Colpi GM, Decobelli O, Salvioni R, Pizzocaro G, Rigatti P, Rocco F. Conservative surgical therapy for leydig cell tumor. J Urol 2007 ; 178: 507-511.
18. Wegner HE, Dieckmann KP, Herbst H, Andresen R, Miller K. Leydig cell tumor comparison of results of radical and testis -sparing surgery in a single centre. Urol Int 1997; 59: 170-173.
19. Bach AM, Hann LE, Hadar O, Shi W, Yoo HH, Giess CS, Sheinfeld J, Thaler H. Testicular microlithiasis: what is its association with testicular cancer ? Radiology 2001; 220: 70-75.
20. Cheville JC, Sebo TJ, Lager DJ, Bostwick DG, Farrow GM. Leydig cell tumor of the testis: clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasising tumors. Am J Surg Pathol 1998; 22: 1361-1367.