Leishmania major: Secreted antigens of Leishmania major promastigotes shift the immune response of the C57BL/6 mice toward Th2 in vitro

Experimental Parasitology

Volumn 127, Issue 1, 2011, Pages 46-51

  Tabatabaee, Parisa alsadat ^a   Abolhassani, Mohsen ^a   Mahdavi, Mehdi ^a   Nahrevanian, Hossein ^a   Azadmanesh, Kayhan ^a  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

C57BL 6; Immunosuppression; Leishmania major; Promastigote; Secreted factors

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; NITRIC OXIDE; PARASITE ANTIGEN;

ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; IMMUNOREGULATION; INFECTION RESISTANCE; LEISHMANIA MAJOR; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PARASITE IMMUNITY; PARASITE SURVIVAL; PRIORITY JOURNAL; PROMASTIGOTE; TH2 CELL;

ANIMALS; ANTIGENS, PROTOZOAN; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CHROMATOGRAPHY, GEL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; INTERFERON-GAMMA; INTERLEUKIN-4; LEISHMANIA MAJOR; LYMPHOCYTES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; NITRIC OXIDE; SPLEEN; TH2 CELLS;

LEISHMANIA MAJOR; MUS;

EID: 78650543163     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2010.06.033     Document Type: Article

References (34)

1. Abolhassani M., Darabi H. Partial purification of a potent immunosuppressive factor excreted from Leishmania major promastigote and amastigote. Iranian Biomedical Journal 2004, 8:95-99.
2. Alexander J., Bryson K. Th1/Th2 and Leishmania: Paradox rather than paradigm. Immunology Letters 2005, 99:17-23.
3. Badaro R., Jones T.C., Carvalho E.M., Sampaio D., Reed S.G., Barral A., Teixeira R., Johnson W.D. New perspectives on a subclinical form of visceral leishmaniasis. Journal of Infectious Diseases 1986, 154:1003-1011.
4. Benach J.L., Bosler E.M., Hanrahan J.P., Coleman J.L., Habicht G.S., Bast T.F., Cameron D.J., Ziegler J.L., Barbour A.G., Burgdorfer W., Edelman R., Kaslow R.A. Spirochetes isolated from the blood of two patients with Lyme disease. New England Journal of Medicine 1983, 308:740-742.
5. Bogdan C., Rollinghoff M., Diefenbach A. The role of nitric oxide in innate immunity. Immunological Reviews 2000, 173:17-26.
6. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976, 72:248-254.
7. Change K.P., Reed S.G., MCGwire B.S., Soong L. Leishmania model for microbial virulence. the relevance of parasite multiplication and pathoantigenicity. Acta Tropica 2003, 85:375-390.
8. Cobrera M., Rodriguez O., Monsalva I., Tovar R., Hagel I. Variations in the serum levels of soluble CD23, nitric oxide and IgE across the spectrum of American cutaneous leishmaniasis. Acta Tropica 2003, 88:145-151.
9. Davidson R.N. Visceral leishmaniasis in clinical practice. The Journal of Infection 1999, 39:112-116.
10. De Almeida M.C., Vilhena V., Barral A., Barral Netto M. Leishmanial infection: analysis of its first steps. Memorias do Instituto Oswaldo Cruz 2003, 98:861-870.
11. + T cells in resistance to cutaneous leishmaniasis in immunized mice. Journal of Immunology 1989, 142:2052-2056.
12. Filippi C., Hugues S., Cazareth J., Julia V., Glaichenhaus N., Ugolini S. CD4+ T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells. Journal of Experimental Medicine 2003, 198:201-209.
13. Fingerle V., Liegl G., Munderloh U., Wilske B. Expression of outer surface proteins A and C of Borrelia burgdorferi in Ixodes ricinus ticks removed from humans. Medical Microbiology and Immunology 1998, 187:121-126.
14. Green M.S., Kark J.D., Witztum E., Greenblatt C.L., Spira D.T. Frozen stored Leishmania tropica vaccine: the effects of dose, route of administration and storage on the Israel Defense Forces. Transactions of the Royal Society of Tropical Medicine 1983, 77:152-159.
15. Ilg T., Stierhof Y.D., Craik D., Simpson R., Handman E., Bacic A. Purification and structural characterization of a filamentous, mucin-like proteophosphoglycan secreted by Leishmania parasites. The Journal of Biological Chemistry 1996, 271:21583-21596.
16. Kamhawi S. The biological and immunomodulatory properties of sand fly saliva and its role in the establishment of Leishmania infections. Microbes and Infection 2000, 2:1765-1773.
17. Kaye P.M., Curry A.J., Bancroft G.J., Lang T. Antigen processing and presentation: modeling with Leishmania. Behring Institute Mitteilungen 1991, 88:13-19.
18. 4. Nature (London) 1970, 227:680-685.
19. Lemesre J.L., Holzmuller P., Cavaleyra M., Goncalves R.B., Hottin G., Papierok G. Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes. Vaccine 2005, 23:2825-2840.
20. Liplodova M., Svobodova M., Krulova M., Havelkova H., Badalova J., Nohynkova E., Holan V., Hart A.A., Volf P., Demant P. Susceptibility to Leishmania major infection in mice. multiple loci and heterogeneity of immunopathological phenotypes. Genes and Immunity 2000, 1:200-206.
21. Mahmoodi M., Khamesipour A., Dowlati Y., Rafati S., Momeni A.Z., Emamjomeh M., Hejazi H., Modabber F. Immune response measured in human volunteers vaccinated with autoclaved Lishmania major vaccine mixed with low dose of BCG. Clinical and Experimental Immunology 2003, 134:303-308.
22. Miralles G.D., Stoeckle M.Y., McDermott D.F., Finkelman F.D., Murray H.W. Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis. Infection and Immunity 1994, 62:1058-1063.
23. Mosmann T.R., Fung T.A.T. Specific assays for cytokine production by T cells. Journal of Immunological Methods 1989, 116:151-155.
24. Muller I., Kropf P., Etges R.J., Louis J.A. Gamma interferon response in secondary Leishmania major infection: role of CD8+T cells. Infection and Immunity 1993, 61:3730-3738.
25. Ritting M.G., Bogdan C. Leishmania-host-cell interaction: complexities and alternative views. Parasitology Today 2000, 16:292-297.
26. Roberts M.T.M. Current understandings on the immunology of Leishmaniasis and recent developments in prevention and treatment. British Medical Bulletin 2006, 75-76:115-130.
27. Sacks D., Anderson C. Re-examination of the immunosuppressive mechanisms mediating non-curve of Leishmania infection in mice. Immunological Reviews 2004, 201:225-238.
28. Salman S.M., Rubeiz N.G., Kibbi A.G. Cutaneous leishmaniasis: clinical features and diagnosis. Clinical Dermatology 1999, 17:291-296.
29. Santarem N., Silvestre R., Tavares J., Silva M., Cabral S., Maciel J., Cordeiro-Da-Silva A. Immune response regulation by Leishmania secreted and non-secreted antigens. Journal of Biomedicine and Biotechnology 2007, 2007:1-10.
30. Satoskar A., Bluethmann H., Alexander J. Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection. Infection and Immunity 1995, 63:4894-4899.
31. Simon N.M., Schaible U.E., Wallich R., Kramer M.D. A mouse model for Borrelia burgdorferi infection: Approach to a vaccine against Lyme disease. Immunology Today 1991, 12:11-16.
32. von Stebut E., Udey M.C. Requirements for Th1-dependent immunity against infection with Leishmania major. Microbes and Infection 2004, 6:1102-1109.
33. von Stebut E., Udey M.C. Requirements for Th1-dependent immunity against infection with Leishmania major. Microbes and Infection 2004, 6:1102-1109.
34. Webb J.R., Campos-Neto A., Ovendale P.J., Martin T.I., Stromberg E.J., Badaro R., Reed S.G. Human and murine immune responses to a novel Leishmania major recombinant protein encoded by members of a multi-copy gene family. Infection and Immunity 1998, 66:3279-3289.