AluYb8 insertion in the MUTYH gene is related to increased 8-OHdG in genomic DNA and could be a risk factor for type 2 diabetes in a Chinese population

Molecular and Cellular Endocrinology

Volumn 332, Issue 1-2, 2011, Pages 301-305

  Chen, Huimei ^a,b   Sun, Caixia ^a,b   Guo, Wenwen ^a,b   Meng, Ran ^a,b   Du, Hong ^a   Qi, Qiufeng ^a,b   Gu, Xin ^a,b   Li, Lirong ^b   Zhang, Kui ^b   Zhu, Dalong ^b   Wang, Yaping ^a,b  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

8 OHdG; Association study; Gene polymorphism; MUTYH gene; Type 2 diabetes mellitus

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CELL DNA; DNA GLYCOSYLASE MUTY; GENOMIC DNA;

ADULT; ARTICLE; CASE CONTROL STUDY; CELL LEVEL; CHINESE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENE INSERTION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ONSET AGE; PATHOGENESIS; POPULATION RESEARCH; PRIORITY JOURNAL; WILD TYPE;

ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; DEOXYGUANOSINE; DIABETES MELLITUS, TYPE 2; DNA; DNA GLYCOSYLASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; MUTAGENESIS, INSERTIONAL; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 78650522288     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.11.021     Document Type: Article

References (29)

1. Al-Tassan N., Chmiel N.H., Maynard J., Fleming N., Livingston A.L., Williams G.T., Hodges A.K., Davies D.R., David S.S., Sampson J.R., Cheadle J.P. Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors. Nat Genet 2002, 30:227-232.
2. Atlantis E., Browning C., Sims J., Kendig H. Diabetes incidence associated with depression and antidepressants in the Melbourne Longitudinal Studies on Healthy Ageing (MELSHA). Int J Geriatr Psychiatry 2010, 25:688-696.
3. Blasiak J., Arabski M., Krupa R., Wozniak K., Zadrozny M., Kasznicki J., Zurawska M., Drzewoski J. DNA damage and repair in type 2 diabetes mellitus. Mutat Res 2004, 554:297-304.
4. Chung H.Y., Cesari M., Anton S., Marzetti E., Giovannini S., Seo A.Y., Carter C., Yu B.P., Leeuwenburgh C. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 2009, 8:18-30.
5. Dandona P., Thusu K., Cook S., Snyder B., Makowski J., Armstrong D., Nicotera T. Oxidative damage to DNA in diabetes mellitus. Lancet 1996, 347:444-445.
6. Dherin C., Radicella J.P., Dizdaroglu M., Boiteux S. Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations. Nucleic Acids Res 1999, 27:4001-4007.
7. Donnelly R., Wang B., Qu X. Type 2 diabetes in China: partnerships in education and research to evaluate new antidiabetic treatments. Br J Clin Pharmacol 2006, 61:702-705.
8. Evans J.L., Goldfine I.D., Maddux B.A., Grodsky G.M. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002, 23:599-622.
9. Halliwell B. Oxygen and nitrogen are pro-carcinogens, damage to DNA by reactive oxygen, chlorine and nitrogen species: measurement, mechanism and the effects of nutrition. Mutat Res 1999, 443:37-52.
10. Kasznicki J., Krupa R., Blasiak J., Drzewoski J. Association between polymorphisms of the DNA repair genes XRCC1 and hOGG1 and type 2 diabetes mellitus in the Polish population. Pol Arch Med Wewn 2009, 119:122-128.
11. Maritim A.C., Sanders R.A., Watkins J.B. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 2003, 17:24-38.
12. Michaels M.L, Tchou J., Grollman A.P., Miller J.H. A repair system for 8-oxo-7,8-dihydrodeoxyguanine. Biochemistry 1992, 31:10964-10968.
13. Minowa O., Arai T., Hirano M., Monden Y., Nakai S., Fukuda M., Itoh M., Takano H., Hippou Y., Aburatani H., Masumura K., Nohmi T., Nishimura S., Noda T. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proc Natl Acad Sci USA 2000, 97:4156-4161.
14. Ohtsubo T., Nishioka K., Imaiso Y., Iwai S., Shimokawa H., Oda H., Fujiwara T., Nakabeppu Y. Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. Nucleic Acids Res 2000, 28:1355-1364.
15. Organization, W.H., 1999. Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications. Geneva, S.D.o.N.D.S., WHO (Ed.), Department of Noncommunicable Disease Surveillance, WHO, Geneva, Switzerland.
16. Park K., Gross M., Lee D.H., Holvoet P., Himes J.H., Shikany J.M., Jacobs D.R. Oxidative stress and insulin resistance: the coronary artery risk development in young adults study. Diabetes Care 2009, 32:1302-1307.
17. Pierce M.B., Zaninotto P., Steel N., Mindell J. Undiagnosed diabetes-data from the English longitudinal study of ageing. Diabet Med 2009, 26:679-685.
18. Robertson A.B., Klungland A., Rognes T., Leiros I. DNA repair in mammalian cells: base excision repair: the long and short of it. Cell Mol Life Sci 2009, 66:981-993.
19. Shah S., Iqbal M., Karam J., Salifu M., McFarlane S.I. Oxidative stress, glucose metabolism, and the prevention of type 2 diabetes: pathophysiological insights. Antioxid Redox Signal 2007, 9:911-929.
20. Shimoi K., Kasai H., Yokota N., Toyokuni S., Kinae N. Comparison between high-performance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-2'-deoxyguanosine in human urine. Cancer Epidemiol Biomarkers Prev 2002, 11:767-770.
21. Shinmura K., Yamaguchi S., Saitoh T., Kohno T., Yokota J. Somatic mutations and single nucleotide polymorphisms of base excision repair genes involved in the repair of 8-hydroxyguanine in damaged DNA. Cancer Lett 2001, 166:65-69.
22. Simone S., Gorin Y., Velagapudi C., Abboud H.E., Habib S.L. Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase. Diabetes 2008, 57:2626-2636.
23. Song F., Jia W., Yao Y., Hu Y., Lei L., Lin J., Sun X., Liu L. Oxidative stress, antioxidant status and DNA damage in patients with impaired glucose regulation and newly diagnosed Type 2 diabetes. Clin Sci (Lond) 2007, 112:599-606.
24. Sun C., Chen H., Guo W., Zhang K., Qi Q., Gu X., Zhu D., Wang Y. A common mutation of the MYH gene is associated with increased DNA oxidation and age-related diseases. Free Radic Biol Med 2010, 48:430-436.
25. Sun C., Liu X., Zhang H., Guo W., Cai Z., Chen H., Zhang K., Zhu D., Wang Y. Functional polymorphism of hOGG1 gene is associated with type 2 diabetes mellitus in Chinese population. Mol Cell Endocrinol 2010, 325:128-134.
26. Wang J.A., Tanya, Geiss L.S., Engelgau M.M. Obesity and diabetes: dual epidemics on the rise. Diabetes and the endocrine pancreas. Curr Opin Endocrinol Diabetes 2005, 12(2):174-180.
27. Xie Y., Yang H., Cunanan C., Okamoto K., Shibata D., Pan J., Barnes D.E., Lindahl T., McIlhatton M., Fishel R., Miller J.H. Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res 2004, 64:3096-3102.
28. Yoon K.H., Lee J.H., Kim J.W., Cho J.H., Choi Y.H., Ko S.H., Zimmet P., Son H.Y. Epidemic obesity and type 2 diabetes in Asia. Lancet 2006, 368:1681-1688.
29. Zharkov D.O. Base excision DNA repair. Cell Mol Life Sci 2008, 65:1544-1565.