Optimisation of the glycerol-to-ornithine molar ratio in the feed medium for the continuous production of clavulanic acid by Streptomyces clavuligerus

Biochemical Engineering Journal

Volumn 53, Issue 1, 2010, Pages 7-11

  Domingues, Letícia C G ^a   Teodoro, Juliana C ^b   Hokka, Carlos O ^b   Badino, Alberto C ^b   Araujo, Maria Lucia G C ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

Author keywords

Bioprocess design; Clavulanic acid; Continuous culture; Glycerol; Optimisation; Ornithine; Streptomyces clavuligerus; Submerged culture

Indexed keywords

BIOPROCESS DESIGN; CLAVULANIC ACID; CONTINUOUS CULTURE; OPTIMISATIONS; ORNITHINE; STREPTOMYCES CLAVULIGERUS; SUBMERGED CULTURES;

BIOCHEMISTRY; BOTTLES; CARBOXYLIC ACIDS; CONCENTRATION (PROCESS); DESIGN; GLYCEROL; OPTIMIZATION;

AMINO ACIDS;

AMINO ACID; ARGININE; CLAVULANIC ACID; GLYCEROL; ORNITHINE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BATCH FERMENTATION; BIOREACTOR; CARBON SOURCE; CONCENTRATION (PARAMETERS); CULTURE MEDIUM; ENERGY RESOURCE; NONHUMAN; PRIORITY JOURNAL; RESPONSE SURFACE METHOD; STATISTICAL ANALYSIS; STREPTOMYCES CLAVULIGERUS;

STREPTOMYCES CLAVULIGERUS;

EID: 78650518489     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2009.05.006     Document Type: Article

References (14)

1. Elander R.P. Industrial production of β-lactam antibiotics. Appl. Microb. Biotechnol. 2003, 61(5-6):385-392.
2. Trovatti E., Badino Junior A.C., Hokka C.O., Araujo M.L.G.C. Influence of free amino acids on clavulanic acid production by Streptomyces clavuligerus in synthetic medium. Braz. Arch. Biol. Technol. 2006, 49:173-179.
3. Romero J., Liras P., Martin J.F. Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 1984, 20:318-325.
4. Romero J., Liras P., Martin J.F. Utilization of ornithine and arginine as specific precursors of clavulanic acid. Appl. Environ. Microbiol. 1986, 52:892-897.
5. Ives P.R., Bushell M.E. Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus. Microbiology 1997, 143:3573-3579.
6. Bushell M.E., Kirk S., Zhao H.-J., Rosa C.A. Manipulation of the physiology of clavulanic acid biosynthesis with the aid of metabolic flux analysis. Enzyme Microb. Technol. 2006, 39:149-157.
7. Kirk S., Avignone-Rosa C.A., Bushell M.E. Growth limiting substrate affects antibiotic production and associated metabolic fluxes in Streptomyces clavuligerus. Biotechnol. Lett. 2000, 22:1803-1809.
8. Chen K.-C., Lin Y.-H., Wu J.-Y., Hwang S-C.J. Enhancement of clavulanic acid production in Streptomyces clavuligerus with ornithine feeding. Enzyme Microb. Technol. 2003, 32:152-156.
9. Box G.E.P., Hunter W.G., Hunter J.S. Statistics for Experimenters 1978, John Wiley and Sons, New York, 655p.
10. Rodrigues M.I., Iemma A.F. Planejamento de experimentos e otimização de processos 2005, Casa do Pão Editora, Campinas, SP, 325p.
11. Bird A.E., Bellis J.M., Gasson B.C. Spectrophotometric assay of clavulanic acid by reaction with imidazole. Analyst 1982, 107:1241-1245.
12. Lambert M., Neish A.C. Rapid method for estimation of glycerol in fermentation solution. Can. J. Res. 1950, 28:83-89.
13. Butterworth D. Clavulanic acid: properties biosynthesis, and fermentation. Biotechnology of Industrial Antibiotics 1984, 3-31. M. Dekker, New York. E.J. Vandame (Ed.).
14. W.T.A.M. De Laat, P. Krabben. Fermentation process to produce clavulanic acid at a low concentration of free amino acids. WO/2000/001840, 03 July 1998, 13 January 2000.