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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 106-109

Inhibition of P-glycoprotein-mediated Multidrug Resistance (MDR) by N,N-bis(cyclohexanol)amine aryl esters: Further restriction of molecular flexibility maintains high potency and efficacy

(9) Martelli, Cecilia a Dei, Silvia a Lambert, Catherine b Manetti, Dina a Orlandi, Francesca a Romanelli, Maria Novella a Scapecchi, Serena a Salerno, Milena b Teodori, Elisabetta a

a UNIVERSITY OF FLORENCE (Italy)

b UNIVERSITÉ PARIS 13 (France)

Author keywords

Chemosensitizers; Doxorubicin resistant erythroleukemia K562 cells (K562 DOX); MDR reverters; N,N Bis(cyclohexanol)amine aryl esters; Pgp inhibitors; Pirarubicin uptake

Indexed keywords

ESTER DERIVATIVE; GLYCOPROTEIN P INHIBITOR;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG EFFICACY; DRUG POTENCY; ESTERIFICATION; MULTIDRUG RESISTANCE; STRUCTURE ACTIVITY RELATION;

AMINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYCLOHEXANOLS; DRUG RESISTANCE, NEOPLASM; ESTERS; HUMANS; ISOMERISM; MOLECULAR CONFORMATION; P-GLYCOPROTEIN;

EID: 78650515803 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.11.059 Document Type: Article

Times cited : (15)

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