Structure-activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 182-185

  Yang, Shu Wei ^a   Smotryski, Jennifer ^a   Matasi, Julius ^a   Ho, Ginny ^a   Tulshian, Deen ^a   Greenlee, William J ^a   Brusa, Rossella ^a   Beltramo, Massimiliano ^a   Cox, Kathleen ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Agonist; Cannabinoid; CB2; Chronic pain

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; IMIDAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHRONIC PAIN; DRUG POTENCY; DRUG SELECTIVITY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CHRONIC DISEASE; HUMANS; IMIDAZOLES; PAIN; RATS; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650513898     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.11.044     Document Type: Article

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