Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 1, 2011, Pages 431-434

  Shibue, Taku ^a   Okamoto, Iwao ^b   Morita, Nobuyoshi ^b   Morita, Hiroshi ^c   Hirasawa, Yusuke ^c   Hosoya, Takahiro ^c   Tamura, Osamu ^b  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^c HOSHI UNIVERSITY   (Japan)

Author keywords

Antiproliferative activity; Inhibition of tubulin polymerization; Tubulysin D

Indexed keywords

11 EPI TUBULYSIN V; 13 EPI TUBULYSIN D; ANTINEOPLASTIC AGENT; PRETUBULYSIN; TETRAPEPTIDE; TUBULYSIN A; TUBULYSIN D; TUBULYSIN V; TUBUVALINE; UNCLASSIFIED DRUG; WZY III 69A;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; STEREOISOMERISM;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; OLIGOPEPTIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 78650513266     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.118     Document Type: Article

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