Highly efficient one-pot synthesis of D-ring chloro-substituted neocryptolepines via a condensation - Pd-catalyzed intramolecular direct arylation strategy

Tetrahedron

Volumn 67, Issue 3, 2011, Pages 655-659

  Hostyn, Steven ^a   Tehrani, Kourosch Abbaspour ^a   Lemire, Filip ^a   Smout, Veerle ^a   Maes, Bert U W ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

C H Activation; Intramolecular direct arylation; Malaria; One pot

Indexed keywords

2,3 DIBROMO 1 METHYLPYRIDINIUMTRIFLUOROMETHANESULFONATE; 3 BROMO 2 CHLORO 1 METHYLQUINOLINIUM TRIFLATE; 3 BROMO 2 CHLORO 1 METHYLQUINOLINIUM TRIFLUOROMETHANESULFONATE; 3 BROMO 2 CHLOROQUINOLINE; 5 METHYL 5H INDOLO[2,3 B]QUINOLINE; 6 CHLORO 1 METHYL 1H PYRIDO[2,3 B]INDOLE; 7 CHLORO 1 METHYL 1H PYRIDO[2,3 B]INDOLE; 7 CHLORO 5 METHYL 5H INDOLO[2,3 B]QUINOLINE; 8 CHLORO 1 METHYL 1H PYRIDO[2,3 B]INDOLE; 8 CHLORO 5 METHYL 5H INDOLO[2,3 B]QUINOLINE; 9 CHLORO 5 METHYL 5H INDOLO[2,3 B]QUINOLINE; ANTIMALARIAL AGENT; N [3 BROMO 1 METHYLPYRIDIN 2(1H) YLIDENE] 2 CHLOROANILINE; N [3 BROMO 1 METHYLPYRIDIN 2(1H) YLIDENE] 3 CHLOROANILINE; N [3 BROMO 1 METHYLPYRIDIN 2(1H) YLIDENE] 4 CHLOROANILINE; NEOCRYPTOLEPINE DERIVATIVE; PALLADIUM; QUINOLINE DERIVATIVE; TRIFLUOROMETHANESULFONIC ACID METHYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; ARYLATION; CATALYSIS; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG SYNTHESIS; METHYLATION; ONE POT SYNTHESIS; PRIORITY JOURNAL;

EID: 78650512916     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.10.077     Document Type: Article

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