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Volumn 67, Issue 3, 2011, Pages 612-617

Regioselective synthesis of 1,3,5- and 1,3,4,5-substituted pyrazoles via acylation of N-Boc-N-substituted hydrazones

Author keywords

1,3,4,5 Tetrasubstituted pyrazoles; 1,3,5 Trisubstituted pyrazoles; N Boc N methylhydrazone acylation; Regioselective pyrazole synthesis

Indexed keywords

1 METHYL 3 PHENYL 5 O TOLYL 1H PYRAZOLE; 1 METHYL 3,5 DIPHENYL 1H PYRAZOLE; 1 METHYL 5 PHENYL 3 O TOLYL 1H PYRAZOLE; 1,3 DIMETHYL 5 PHENYL 1H PYRAZOLE; 1,3,4,5 PYRAZOLE DERIVATIVE; 1,3,5 PYRAZOLE DERIVATIVE; 1,4 DIMETHYL 3,5 DIPHENYL 1H PYRAZOLE; 2 (1 METHYL 5 PHENYL 1H PYRAZOL 3 YL)PYRIDINE; 2 METHYL 3 PHENYL 4,5,6,7 TETRAHYDRO 2H INDAZOLE; 3 ETHYL 1,4 DIMETHYL 5 PHENYL 1H PYRAZOLE; 3 TERT BUTYL 1 METHYL 5 PHENYL 1H PYRAZOLE; 4 FLUORO 1 METHYL 3,5 DIPHENYL 1H PYRAZOLE; 5 TERT BUTYL 1 METHYL 3 PHENYL 1H PYRAZOLE; HYDRAZONE DERIVATIVE; PYRAZOLE DERIVATIVE; TERT BUTYL 1 METHYL 2 (2 METHYL 1 OXO 1 PHENYLPENTAN 3 YLIDENE)HYDRAZINECARBOXYLATE; TERT BUTYL 1 METHYL 2 (2 METHYL 3 OXO 1,3 DIPHENYLPROPYLIDENE)HYDRAZINECARBOXYLATE; TERT BUTYL 1 METHYL 2 (3 OXO 1 PHENYL 3 O TOLYLPROP 1 ENYL)HYDRAZINECARBOXYLATE; TERT BUTYL 1 METHYL 2 (3 OXO 1,3 DIPHENYLPROPYLIDENE)HYDRAZINECARBOXYLATE; TERT BUTYL 1 METHYL 2 (3 OXO 3 PHENYL 1 O TOLYLPROPYLIDENE)HYDRAZINECARBOXYLATE; TERT BUTYL 1 METHYL 2 (4 OXO 4 PHENYLBUTAN 2 YLIDENE)HYDRAZINECARBOXYLATE; TERT BUTYL 1 METHYL 2 [3 OXO 3 PHENYL 1 (PYRIDIN 2 YL)PROPYLIDENE]HYDRAZINECARBOXYLATE; TERT BUTYL 2 (2 BENZOYLCYCLOHEXYLIDENE) 1 METHYLHYDRAZINECARBOXYLATE; TERT BUTYL 2 (2 FLUORO 3 OXO 1,3 DIPHENYLPROPYLIDENE) 1 METHYLHYDRAZINECARBOXYLATE; TERT BUTYL 2 (4,4 DIMETHYL 1 OXO 1 PHENYLPENTAN 3 YLIDENE) 1 METHYLHYDRAZINECARBOXYLATE; TERT BUTYL 2 (4,4 DIMETHYL 3 OXO 1 PHENYLPENTYLIDENE) 1 METHYLHYDRAZINECARBOXYLATE; UNCLASSIFIED DRUG;

EID: 78650512640     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.11.057     Document Type: Article
Times cited : (14)

References (24)
  • 4
    • 41849118342 scopus 로고
    • L. Knorr Ber. 16 1883 2587
    • (1883) Ber. , vol.16 , pp. 2587
    • Knorr, L.1
  • 16
    • 78650511118 scopus 로고    scopus 로고
    • All hydrazones 2 and 8 were obtained by condensation of commercially available 1-(tert-butyloxycarbonyl)-1-methylhydrazine and the corresponding ketone
    • All hydrazones 2 and 8 were obtained by condensation of commercially available 1-(tert-butyloxycarbonyl)-1-methylhydrazine and the corresponding ketone.
  • 17
    • 8644279653 scopus 로고    scopus 로고
    • A general preparation of N-BOC-N-substituted hydrazones is reported: K.G. Meyer Synlett 2004 2355 Some of these hydrazones were tested and gave very similar results to those obtained with 1-BOC-1-methylhydrazones
    • (2004) Synlett , pp. 2355
    • Meyer, K.G.1
  • 18
    • 78650511083 scopus 로고    scopus 로고
    • Most of the ketoimine products were isolated as the corresponding enaminones. See Supporting data for details
    • Most of the ketoimine products were isolated as the corresponding enaminones. See Supporting data for details.
  • 20
    • 78650516502 scopus 로고    scopus 로고
    • A variety of acylating agents, such as alkyl and aromatic acyl anhydrides, chlorides and esters can be used for the acylation of hydrazones. See Ref. 11
    • A variety of acylating agents, such as alkyl and aromatic acyl anhydrides, chlorides and esters can be used for the acylation of hydrazones. See Ref. 11.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.