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Volumn 171, Issue 1, 2011, Pages 11-21

Molecular Mechanisms of Resistance to 5-Fluorocytosine in Laboratory Mutants of Candida glabrata

Author keywords

5 Fluorocytosine; Candida glabrata; FUR1, FCY1 and FCY2 genes; Resistance mechanisms

Indexed keywords

CANDIDA GLABRATA;

EID: 78650511059     PISSN: 0301486X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11046-010-9342-1     Document Type: Article
Times cited : (44)

References (34)
  • 1
    • 0036550465 scopus 로고    scopus 로고
    • Non-albicansCandida spp. causing fungaemia: Pathogenicity and antifungal resistance
    • Krcmery V, Barnes AJ. Non-albicansCandida spp. causing fungaemia: pathogenicity and antifungal resistance. J Hosp Infect. 2002; 50: 243-60.
    • (2002) J Hosp Infect , vol.50 , pp. 243-260
    • Krcmery, V.1    Barnes, A.J.2
  • 2
    • 34248399613 scopus 로고    scopus 로고
    • Risk of resistance associated with fluconazole prophylaxis: Systematic review
    • Brion LP, Uko SE, Goldman DL. Risk of resistance associated with fluconazole prophylaxis: systematic review. J Infect. 2007; 54: 521-9.
    • (2007) J Infect , vol.54 , pp. 521-529
    • Brion, L.P.1    Uko, S.E.2    Goldman, D.L.3
  • 3
    • 33947375620 scopus 로고    scopus 로고
    • Candida glabrata: An emerging oral opportunistic pathogen
    • Li L, Redding S, Dongari-Bagtzoglou A. Candida glabrata: an emerging oral opportunistic pathogen. J Dent Res. 2007; 86: 204-15.
    • (2007) J Dent Res , vol.86 , pp. 204-215
    • Li, L.1    Redding, S.2    Dongari-Bagtzoglou, A.3
  • 4
    • 30744462355 scopus 로고    scopus 로고
    • Results from the ARTEMIS DISK Global Antifungal Surveillance Study: A 6.5-year analysis of susceptibilities of Candida and other yeast species to fluconazole and voriconazole by standardized disk diffusion testing
    • the Global Antifungal Surveillance Group
    • Pfaller MA, Diekema DJ, Rinaldi MG, Barnes R, Hu B, Veselov AV, Tiraboschi N, Nagy E, Gibbs DL, the Global Antifungal Surveillance Group. Results from the ARTEMIS DISK Global Antifungal Surveillance Study: a 6. 5-year analysis of susceptibilities of Candida and other yeast species to fluconazole and voriconazole by standardized disk diffusion testing. J Clin Microbiol. 2005; 43: 5848-59.
    • (2005) J Clin Microbiol , vol.43 , pp. 5848-5859
    • Pfaller, M.A.1    Diekema, D.J.2    Rinaldi, M.G.3    Barnes, R.4    Hu, B.5    Veselov, A.V.6    Tiraboschi, N.7    Nagy, E.8    Gibbs, D.L.9
  • 5
    • 0036720774 scopus 로고    scopus 로고
    • Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989-1999
    • the National Nosocomial Infections Surveillance System Hospitals
    • Trick WE, Fridkin SK, Edwards JR, Hajjeh RA, Gaynes RP, the National Nosocomial Infections Surveillance System Hospitals. Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989-1999. Clin Infect Dis. 2002; 35: 622-30.
    • (2002) Clin Infect Dis , vol.35 , pp. 622-630
    • Trick, W.E.1    Fridkin, S.K.2    Edwards, J.R.3    Hajjeh, R.A.4    Gaynes, R.P.5
  • 6
    • 22544444651 scopus 로고    scopus 로고
    • A yeast by any other name: Candida glabrata and its interaction with the host
    • Kaur R, Domergue R, Zupancic ML, Cormack BP. A yeast by any other name: Candida glabrata and its interaction with the host. Curr Opin Microbiol. 2005; 8: 378-84.
    • (2005) Curr Opin Microbiol , vol.8 , pp. 378-384
    • Kaur, R.1    Domergue, R.2    Zupancic, M.L.3    Cormack, B.P.4
  • 7
    • 0036205767 scopus 로고    scopus 로고
    • Caspofungin: An echinocandin antifungal agent
    • Stone EA, Fung HB, Kirschenbaum HL. Caspofungin: an echinocandin antifungal agent. Clin Ther. 2002; 24: 351-77.
    • (2002) Clin Ther , vol.24 , pp. 351-377
    • Stone, E.A.1    Fung, H.B.2    Kirschenbaum, H.L.3
  • 8
    • 0036488166 scopus 로고    scopus 로고
    • Resistance of Candida species to antifungal agents: Molecular mechanisms and clinical consequences
    • Sanglard D, Odds FC. Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences. Lancet Infect Dis. 2002; 2: 73-85.
    • (2002) Lancet Infect Dis , vol.2 , pp. 73-85
    • Sanglard, D.1    Odds, F.C.2
  • 9
    • 0033869563 scopus 로고    scopus 로고
    • Flucytosine: A review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions
    • Vermes A, Guchelaar HJ, Dankert J. Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother. 2000; 46: 171-9.
    • (2000) J Antimicrob Chemother , vol.46 , pp. 171-179
    • Vermes, A.1    Guchelaar, H.J.2    Dankert, J.3
  • 10
    • 84907130661 scopus 로고
    • 5-Fluorocytosine resistance in Candida spp. and Torulopsis glabrata
    • Schönebeck J, Anséhn S. 5-Fluorocytosine resistance in Candida spp. and Torulopsis glabrata. Sabouraudia. 1973; 11: 10-20.
    • (1973) Sabouraudia , vol.11 , pp. 10-20
    • Schönebeck, J.1    Anséhn, S.2
  • 12
    • 0347992029 scopus 로고    scopus 로고
    • Flucytosine resistance is restricted to a single genetic clade of Candida albicans
    • Pujol C, Pfaller MA, Soll DR. Flucytosine resistance is restricted to a single genetic clade of Candida albicans. Antimicrob Agents Chemother. 2004; 48: 262-6.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 262-266
    • Pujol, C.1    Pfaller, M.A.2    Soll, D.R.3
  • 13
    • 0036841275 scopus 로고    scopus 로고
    • In vitro activities of 5-fluorocytosine against 8, 803 clinical isolates of Candida spp.: Global assessment of primary resistance using National Committee for Clinical Laboratory Standards susceptibility testing methods
    • Pfaller MA, Messer SA, Boyken L, Huynh H, Hollis RJ, Diekema DJ. In vitro activities of 5-fluorocytosine against 8, 803 clinical isolates of Candida spp.: global assessment of primary resistance using National Committee for Clinical Laboratory Standards susceptibility testing methods. Antimicrob Agents Chemother. 2002; 46: 3518-21.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3518-3521
    • Pfaller, M.A.1    Messer, S.A.2    Boyken, L.3    Huynh, H.4    Hollis, R.J.5    Diekema, D.J.6
  • 14
    • 0024161448 scopus 로고
    • Isolation and characterization of fluoropyrimidine-resistant mutants in two Candida species
    • Fasoli M, Kerridge D. Isolation and characterization of fluoropyrimidine-resistant mutants in two Candida species. Ann N Y Acad Sci. 1988; 544: 260-3.
    • (1988) Ann N Y Acad Sci , vol.544 , pp. 260-263
    • Fasoli, M.1    Kerridge, D.2
  • 15
    • 33845984046 scopus 로고    scopus 로고
    • Molecular mechanism of flucytosine resistance in Candida lusitaniae: Contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance
    • Papon N, Noël T, Florent M, Gibot-Leclerc S, Jean D, Chastin C, Villard J, Chapeland-Leclerc F. Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance. Antimicrob Agents Chemother. 2007; 51: 369-71.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 369-371
    • Papon, N.1    Noël, T.2    Florent, M.3    Gibot-Leclerc, S.4    Jean, D.5    Chastin, C.6    Villard, J.7    Chapeland-Leclerc, F.8
  • 16
    • 2542436013 scopus 로고    scopus 로고
    • Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans
    • Dodgson AR, Dodgson KJ, Pujol C, Pfaller MA, Soll DR. Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans. Antimicrob Agents Chemother. 2004; 48: 2223-7.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 2223-2227
    • Dodgson, A.R.1    Dodgson, K.J.2    Pujol, C.3    Pfaller, M.A.4    Soll, D.R.5
  • 17
    • 0026564314 scopus 로고
    • Evolving role of flucytosine in immunocompromised patients: New insights into safety, pharmacokinetics, and antifungal therapy
    • Francis P, Walsh TJ. Evolving role of flucytosine in immunocompromised patients: new insights into safety, pharmacokinetics, and antifungal therapy. Clin Infect Dis. 1992; 15: 1003-18.
    • (1992) Clin Infect Dis , vol.15 , pp. 1003-1018
    • Francis, P.1    Walsh, T.J.2
  • 18
    • 0017751121 scopus 로고
    • 5-fluorocytosine-current status with special references to mode of action and drug resistance
    • Polak A. 5-fluorocytosine-current status with special references to mode of action and drug resistance. Contrib Microbiol Immunol. 1977; 4: 158-67.
    • (1977) Contrib Microbiol Immunol , vol.4 , pp. 158-167
    • Polak, A.1
  • 20
    • 0015669158 scopus 로고
    • In vitro studies of 5-fluorocytosine resistance in Candida albicans and Torulopsis glabrata
    • Normark S, Schönebeck J. In vitro studies of 5-fluorocytosine resistance in Candida albicans and Torulopsis glabrata. Antimicrob Agents Chemother. 1972; 2: 114-21.
    • (1972) Antimicrob Agents Chemother , vol.2 , pp. 114-121
    • Normark, S.1    Schönebeck, J.2
  • 21
    • 0025074009 scopus 로고
    • Uptake of pyrimidines and their derivatives into Candida glabrata and Candida albicans
    • Fasoli M, Kerridge D. Uptake of pyrimidines and their derivatives into Candida glabrata and Candida albicans. J Gen Microbiol. 1990; 136: 1475-81.
    • (1990) J Gen Microbiol , vol.136 , pp. 1475-1481
    • Fasoli, M.1    Kerridge, D.2
  • 23
    • 33847611100 scopus 로고    scopus 로고
    • Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth
    • Vandeputte P, Tronchin G, Bergès T, Hennequin C, Chabasse D, Bouchara JP. Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth. Antimicrob Agents Chemother. 2007; 51: 982-90.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 982-990
    • Vandeputte, P.1    Tronchin, G.2    Bergès, T.3    Hennequin, C.4    Chabasse, D.5    Bouchara, J.P.6
  • 25
    • 0037378760 scopus 로고    scopus 로고
    • Flucytosine-fluconazole cross-resistance in purine-cytosine permease-deficient Candida lusitaniae clinical isolates: Indirect evidence of a fluconazole uptake transporter
    • Noël T, François F, Paumard P, Chastin C, Brèthes D, Villard J. Flucytosine-fluconazole cross-resistance in purine-cytosine permease-deficient Candida lusitaniae clinical isolates: indirect evidence of a fluconazole uptake transporter. Antimicrob Agents Chemother. 2003; 47: 1275-84.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1275-1284
    • Noël, T.1    François, F.2    Paumard, P.3    Chastin, C.4    Brèthes, D.5    Villard, J.6
  • 26
    • 47249130356 scopus 로고    scopus 로고
    • Cholesterol dependent and amphotericin B resistant isolates of a Candida glabrata strain from an intensive care unit patient
    • Rezusta A, Aspiroz C, Boekhout T, Cano JF, Theelen B, Guarro J, Rubio MC. Cholesterol dependent and amphotericin B resistant isolates of a Candida glabrata strain from an intensive care unit patient. Med Mycol. 2008; 46: 265-8.
    • (2008) Med Mycol , vol.46 , pp. 265-268
    • Rezusta, A.1    Aspiroz, C.2    Boekhout, T.3    Cano, J.F.4    Theelen, B.5    Guarro, J.6    Rubio, M.C.7
  • 27
    • 0038482076 scopus 로고    scopus 로고
    • Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution
    • Ko TP, Lin JJ, Hu CY, Hsu YH, Wang AH, Liaw SH. Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution. J Biol Chem. 2003; 278: 19111-7.
    • (2003) J Biol Chem , vol.278 , pp. 19111-19117
    • Ko, T.P.1    Lin, J.J.2    Hu, C.Y.3    Hsu, Y.H.4    Wang, A.H.5    Liaw, S.H.6
  • 28
    • 0016689356 scopus 로고
    • Characterization of cytosine permeation in Saccharomyces cerevisiae
    • Chevallier MR, Jund R, Lacroute F. Characterization of cytosine permeation in Saccharomyces cerevisiae. J Bacteriol. 1975; 122: 629-41.
    • (1975) J Bacteriol , vol.122 , pp. 629-641
    • Chevallier, M.R.1    Jund, R.2    Lacroute, F.3
  • 29
    • 0021674542 scopus 로고
    • Photoaffinity labeling and characterization of the cloned purine-cytosine transport system in Saccharomyces cerevisiae
    • Schmidt R, Manolson MF, Chevallier MR. Photoaffinity labeling and characterization of the cloned purine-cytosine transport system in Saccharomyces cerevisiae. Proc Natl Acad Sci USA. 1984; 81: 6276-80.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 6276-6280
    • Schmidt, R.1    Manolson, M.F.2    Chevallier, M.R.3
  • 30
    • 0025329820 scopus 로고
    • The purine-cytosine permease gene of Saccharomyces cerevisiae: Primary structure and deduced protein sequence of the FCY2 gene product
    • Weber E, Rodriguez C, Chevallier MR, Jund R. The purine-cytosine permease gene of Saccharomyces cerevisiae: primary structure and deduced protein sequence of the FCY2 gene product. Mol Microbiol. 1990; 4: 585-96.
    • (1990) Mol Microbiol , vol.4 , pp. 585-596
    • Weber, E.1    Rodriguez, C.2    Chevallier, M.R.3    Jund, R.4
  • 33
    • 0034967775 scopus 로고    scopus 로고
    • New plasmid system to select for Saccharomyces cerevisiae purine-cytosine permease affinity mutants
    • Wagner R, Straub ML, Souciet JL, Potier S, de Montigny J. New plasmid system to select for Saccharomyces cerevisiae purine-cytosine permease affinity mutants. J Bacteriol. 2001; 183: 4386-8.
    • (2001) J Bacteriol , vol.183 , pp. 4386-4388
    • Wagner, R.1    Straub, M.L.2    Souciet, J.L.3    Potier, S.4    de Montigny, J.5
  • 34
    • 23044453091 scopus 로고    scopus 로고
    • Inactivation of the FCY2 gene encoding purine-cytosine permease promotes cross-resistance to flucytosine and fluconazole in Candida lusitaniae
    • Chapeland-Leclerc F, Bouchoux J, Goumar A, Chastin C, Villard J, Noël T. Inactivation of the FCY2 gene encoding purine-cytosine permease promotes cross-resistance to flucytosine and fluconazole in Candida lusitaniae. Antimicrob Agents Chemother. 2005; 49: 3101-8.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3101-3108
    • Chapeland-Leclerc, F.1    Bouchoux, J.2    Goumar, A.3    Chastin, C.4    Villard, J.5    Noël, T.6


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