8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma

Blood

Volumn 116, Issue 25, 2010, Pages 5622-5630

  Dennison, Jennifer B ^a   Shanmugam, Mala ^b   Ayres, Mary L ^a   Qian, Jun ^b   Krett, Nancy L ^b   Medeiros, L Jeffrey ^a   Neelapu, Sattva S ^a   Rosen, Steven T ^b   Gandhi, Varsha ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 AMINOADENOSINE; ADENOSINE TRIPHOSPHATE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEOSIDE DERIVATIVE; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; LYMPHOCYTE; LYMPHOMA CELL LINE; MACROMOLECULE; MANTLE CELL LYMPHOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

EID: 78650505933     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-05-285866     Document Type: Article

References (35)

1. Medeiros LJ, Van Krieken JH, Jaffe ES, Raffeld M. Association of Bcl-1 rearrangements with lymphocytic lymphoma of intermediate differentiation. Blood. 1990;76(10):2086-2090.
2. Motokura T, Bloom T, Kim HG, et al. A novel cyclin encoded by a Bcl1-linked candidate oncogene. Nature. 1991;350(6318):512-515. (Pubitemid 21912266)
3. Stilgenbauer S, Winkler D, Ott G, et al. Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma. Blood. 1999;94(9):3262-3264. (Pubitemid 29512737)
4. Rizzatti EG, Falcao RP, Panepucci RA, et al. Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta; signalling pathways. Br J Haematol. 2005;130(4):516-526.
5. Rudelius M, Pittaluga S, Nishizuka S, et al. Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood. 2006;108(5):1668-1676. (Pubitemid 44316136)
6. Dal Col J, Zancai P, Terrin L, et al. Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma. Blood. 2008;111(10):5142-5151.
7. Psyrri A, Papageorgiou S, Liakata E, et al. Phosphatidylinositol 3′-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma. Clin Cancer Res. 2009;15(18):5724-5732.
8. Witzig TE, Geyer SM, Ghobrial I, et al. Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J Clin Oncol. 2005;23(23):5347-5356. (Pubitemid 46206988)
9. Hess G, Herbrecht R, Romaguera J, et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol. 2009;27(23):3822- 3829.
10. Ansell SM, Inwards DJ, Rowland KM Jr, et al. Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma. Cancer. 2008;113(3):508-514.
11. Rizzieri DA, Feldman E, DiPersio JF, et al. A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res. 2008;14(9):2756-2762.
12. Haritunians T, Mori A, O'Kelly J, Luong QT, Giles FJ, Koeffler HP. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia. 2007;21(2):333-339. (Pubitemid 46158128)
13. Ghias K, Ma C, Gandhi V, Platanias LC, Krett NL, Rosen ST. 8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: role in induction of apoptosis in multiple myeloma. Mol Cancer Ther. 2005;4(4):569-577. (Pubitemid 40601838)
14. Shanmugam M, McBrayer SK, Qian J, et al. Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-Aminoadenosine. J Biol Chem. 2009;284(39):26816-26830.
15. Krett NL, Davies KM, Ayres M, et al. 8-Aminoadenosine is a potential therapeutic agent for multiple myeloma. Mol Cancer Ther. 2004;3(11):1411-1420. (Pubitemid 39562586)
16. Frey JA, Gandhi V. 8-Amino-adenosine inhibits multiple mechanisms of transcription. Mol Cancer Ther. 2010;9(1):236-245.
17. Balakrishnan K, Wierda WG, Keating MJ, Gandhi V. Mechanisms of cell death of chronic lymphocytic leukemia lymphocytes by RNA-directed agent, 8-NH2-adenosine. Clin Cancer Res. 2005;11(18):6745-6752. (Pubitemid 41339018)
18. Chen LS, Sheppard TL. Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs. J Biol Chem. 2004;279(39):40405-40411.
19. Chen LS, Du-Cuny L, Vethantham V, et al. Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochem Pharmacol. 2010;79(5):669-677.
20. Dennison JB, Balakrishnan K, Gandhi V. Preclinical activity of 8-chloroadenosine with mantle cell lymphoma: roles of energy depletion and inhibition of DNA and RNA synthesis. Br J Haematol. 2009;147(3):297-307.
21. Neu HC, Heppel LA. Nucleotide sequence analysis of polyribonucleotides by means of periodate oxidation followed by cleavage with an amine. J Biol Chem. 1964;239(9):2927-2934.
22. Harris BA, Plunkett W. Biochemical basis for the cytotoxicity of 9-beta-D-xylofuranosyladenine in Chinese hamster ovary cells. Cancer Res. 1981;41(3):1039-1044. (Pubitemid 11136358)
23. Yazbeck VY, Buglio D, Georgakis GV, et al. Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma. Exp Hematol. 2008;36(4):443-450. (Pubitemid 351384743)
24. Paoluzzi L, Gonen M, Gardner JR, et al. Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. Blood. 2008;111(11):5350-5358.
25. Rosenwald IB, Kaspar R, Rousseau D, et al. Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. J Biol Chem. 1995;270(36):21176-21180.
26. Diehl JA, Cheng M, Roussel MF, Sherr CJ. Glycogen synthase kinase-beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 1998;12(22):3499-3511. (Pubitemid 28553242)
27. Klier M, Anastasov N, Hermann A, et al. Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2. Leukemia. 2008;22(11):2097-2105.
28. Waskiewicz AJ, Flynn A, Proud CG, Cooper JA. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 1997;16(8):1909-1920. (Pubitemid 27170952)
29. Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional Inactivation of TSC2 by Erk: Implications for tuberous sclerosisand cancer pathogenesis. Cell. 2005;121(2):179-193. (Pubitemid 40546387)
30. Peponi E, Drakos E, Reyes G, Leventaki V, Rassidakis GZ, Medeiros LJ. Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma. Am J Pathol. 2006;169(6):2171-2180. (Pubitemid 351181976)
31. Hipp S, Ringshausen I, Oelsner M, Bogner C, Peschel C, Decker T. Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells. Haematologica. 2005;90(10):1433-1434. (Pubitemid 41503659)
32. Ahn Y-H, Jung JM, Hong SH. 8-Chloro-cyclic AMP-induced growth inhibition and apoptosis Is mediated by p38 mitogen-activated protein kinase activation in HL60 cells. Cancer Res. 2005;65(11):4896-4901. (Pubitemid 40740829)
33. Koresawa M, Okabe T. High-throughput screening with quantitation of ATP consumption: a universal non-radioisotope, homogeneous assay for protein kinase. Assay Drug Dev Technol. 2004;2(2):153-160. (Pubitemid 38647425)
34. Rosenwald A, Wright G, Wiestner A, et al. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell. 2003;3(2):185-197. (Pubitemid 37443390)
35. Gandhi V, Balakrishnan K, Chen LS. Mcl-1: the 1 in CLL. Blood. 2008;112(9):3538-3540.