Lasting neuropathological changes in rat brain after intermittent neonatal administration of thimerosal

Folia Neuropathologica

Volumn 48, Issue 4, 2010, Pages 258-269

  Olczak, Mieszko ^a,b   Duszczyk, Michalina ^a   Mierzejewski, Pawel ^a   Wierzba Bobrowicz, Teresa ^a   Majewska, Maria Dorota ^a,c  

^a INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c CARDINAL STEFAN WYSZY SKI UNIVERSITY   (Poland)

Author keywords

Brain; Development; Neuropathology; Rat; Thimerosal

Indexed keywords

CASPASE 3; SYNAPTOPHYSIN; THIOMERSAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATROPHY; CEREBELLUM; CONTROLLED STUDY; HIPPOCAMPUS; MACROGLIA; NERVE CELL DEGENERATION; NERVE CELL ISCHEMIC DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PERINATAL PERIOD; PREFRONTAL CORTEX; RAT; TEMPORAL CORTEX;

EID: 78650486051     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Anderson BD, Nakamura T, Russell SJ, Peng KW. High CD46 receptor density determines preferential killing of tumor cells by oncolytic measles virus. Cancer Res 2004;64:4919-4926.
2. Baskin DS, Ngo H, Didenko VV. Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts. Toxicol Sci 2003;74:361-368.
3. Berman RF, Pessah IN, Mouton PR, Mav D, Harry J. Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol Sci 2008;101:294-309.
4. Bernard S, Enayati A, Redwood L, Roger H, Binstock T. Autism: a novel form of mercury poisoning. Med Hypotheses 2001;56:462-471.
5. Burbacher TM, Shen DD, Liberato N, Grant KS, Cernichiari E, Clarkson T. Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal. Environ Health Perspect 2005;113:1015-1021.
6. Burke K, Cheng Y, Li B, Petrov A, Joshi P, Berman RF, Reuhl KR, DiCicco-Bloom E. Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E. Neurotoxicology 2006;27:970-981.
7. Dymecki J, Kulczycki J. Neuropatologia. Urban & Partner, Wrocław 2005; pp: 59-79.
8. Eto K, Takizawa Y, Akagi H, Haraguchi K, Asano S, Takahata N, Tokunaga H. Differential diagnosis between organic and inorganic mercury poisoning in human cases - the pathologic point of view. Toxicol Pathol 1999;27:664-671.
9. Eto K, Yasutake A, Kuwana T, Korogi Y, Akima M, Shimozeki T, Tokunaga H, Kaneko Y. Methylmercury poisoning in common marmosets - a study of selective vulnerability within the cerebral cortex. Toxicol Pathol 2001;29:565-573.
10. Eto K, Tokunaga H, Nagashima K, Takeuchi T. An autopsy case of minamata disease (methylmercury poisoning) - pathological viewpoints of peripheral nerves. Toxicol Pathol 2002;30:714-722.
11. Falluel-Morel A, Sokolowski K, Sisti HM, Zhou X, Shors TJ, Dicicco-Bloom E. Developmental mercury exposure elicits acute hippocampal cell death, reductions in neurogenesis, and severe learning deficits during puberty. J Neurochem 2007;103:1968-1981.
12. Gallagher C, Goodman M. Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years. Toxicol Environ Chem 2008;90:997-1008.
13. Geier DA, Geier MR. A meta-analysis epidemiological assessment of neurodevelopmental disorders following vaccines administered from 1994 through 2000 in the United States. Neuro Endocrinol Lett 2006;27:401-413.
14. Hagg T. Molecular regulation of adult CNS neurogenesis: an integrated view. Trends Neurosci 2005;8:589-595.
15. Hewitson L, Lopresti BJ, Stott C, Mason NS, Tomko J. Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study. Acta Neurobiol Exp (Wars) 2010;70:147-164.
16. Higgins GC, Beart PM, Nagley P. Oxidative stress triggers neuronal caspase-independent death: endonuclease G involvement in programmed cell death-type III. Cell Mol Life Sci 2009;66:2773-2787.
17. Hornig M, Chian D, Lipkin WI. Neurotoxic effects of postnatal thimerosal are mouse strain dependent. Mol Psychiatry 2004;9:833-845.
18. Humphrey ML, Cole MP, Pendergrass JC, Kiningham KK. Mitochondrial mediated thimerosal-induced apoptosis in a human neuroblastoma cell line (SK-N-SH). Neurotoxicology 2005;26:407-416.
19. Jacobson, M. Developmental Neurobiology. 2nd ed. Plenum, New York 1991, pp. 41-93.
20. Kövesdi E, Pál J, Gallyas F. The fate of "dark" neurons produced by transient focal cerebral ischemia in a non-necrotic and nonexcitotoxic environment: neurobiological aspects. Brain Res 2007;1147:272-283.
21. Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci 1996;16:2027-2033.
22. Laming PR, Kimelberg H, Robinson S, Salm A, Hawrylak N, Müller C, Roots B, Ng K. Neuronal-glial interactions and behaviour. Neurosci Biobehav Rev 2000;24:295-340.
23. Laurente J, Remuzgo F, Ávalos B, Chiquinta J, Ponce B, Avendaño R, Maya L. Neurotoxic effects of thimerosal at vaccines doses on the encephalon and development in 7 days-old hamsters. Ann Fac Med Lima 2007;68:222-237.
24. Lossi L, Tamagno I, Merighi A. Molecular morphology of neuronal apoptosis: analysis of caspase 3 activation during postnatal development of mouse cerebellar cortex. J Mol Histol 2004;35:621-629.
25. Majewska MD, Urbanowicz E, Rok-Bujko P, Namyslowska I, Mierzejewski P. Age-dependent lower or higher levels of hair mercury in autistic children than in healthy controls. Acta Neurobiol Exp (Wars) 2010;70:196-208.
26. Matyja E, Taraszewska A, Nagańska E, Grieb P, Rafałowska J. CDP-choline protects motor neurons against apoptotic changes in a model of chronic glutamate excitotoxicity in vitro. Folia Neuropathol 2008;46:139-148.
27. Merrick J, Kandel I, Morad M. Trends in autism. Int J Adolesc Med Health 2004;16:75-78.
28. Mossakowski J, Dymecki J, Wender M. Podstawy neuropatologii. PZWL, Warszawa 1981; pp: 64-101.
29. Mutter J, Naumann J, Schneider R, Walach H, Haley B. Mercury and autism: accelerating evidence? Neuro Endocrinol Lett 2005;26:439-446.
30. Nagańska E, Matyja E. Expression of apoptosis-related proteins in model of anoxia in vitro. Folia Neuropathol 2005;43:23-29.
31. Nagashima K. A review of experimental methylmercury toxicity in rats: neuropathology and evidence for apoptosis. Toxicol Pathol 1997;25:624-631.
32. Newschaffer CJ, Falb MD, Gurney JG. National autism prevalence trends from United States special education data. Pediatrics 2005;115: e277-282.
33. Olczak M, Duszczyk M, Mierzejewski P, Majewska MD. Neonatal administration of a vaccine preservative, thimerosal, produces lasting impairment of nociception and apparent activation of opioid system in rats. Brain Res 2009;1301:143-151.
34. Olczak M, Duszczyk M, Mierzejewski P, Majewska MD. Early postnatal Thimerosal administration, in a vaccination-like scheme, causes vast structural damage in rat brain: implications for autism. Act Neurobiol Exp (Wars) 2009;69:309.
35. Olczak M, Duszczyk M, Mierzejewski P, Bobrowicz T, Majewska MD. Neonatal administration of thimerosal causes persistent changes in mu opioid receptors in the rat brain. Neurochem Res 2010;35:1840-1847.
36. Parran DK, Barker A, Ehrich M. Effects of thimerosal on NGF signal transduction and cell death in neuroblastoma cells. Toxicol Sci 2005;86:132-140.
37. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Academic Press, Oxford 2007.
38. Qvarnström J, Lambertsson L, Havarinasab S, Hultman P, Frech W. Determination of methylmercury, ethylmercury, and inorganic mercury in mouse tissues, following administration of thimerosal, by species-specific isotope dilution GC-inductively coupled plasma-MS. Anal Chem 2003;75:4120-4124.
39. Rice DC. Sensory and cognitive effects of developmental methylmercury exposure in monkeys, and a comparison to effects in rodents. Neurotoxicology 1996;17:139-154.
40. Rice D, Barone S Jr. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 2000;108 Suppl 3:511-533.
41. Sajdel-Sulkowska RM, Lipinski B, Windom H, Audhya T, McGinnis W. Oxidative stress in autism: elevated cerebellar 3-nitrotyrosine levels. American Journal of Biochemistry and Biotechnology 2008;4:73-84.
42. Sakamoto M, Kakita A, de Oliveira RB, Sheng Pan H, Takahashi H. Dose-dependent effects of methylmercury administered during neonatal brain spurt in rats. Brain Res Dev Brain Res 2004;152:171-176.
43. Seaberg RM, van der Kooy D. Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. J Neurosci 2002;22:1784-1793.
44. Shanker G, Aschner JL, Syversen T, Aschner M. Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury. Brain Res Mol Brain Res 2004;128:48-57.
45. Slotkin TA, Bartolome J. Biochemical mechanisms of developmental neurotoxicity of methylmercury. Neurotoxicology 1987;8:65-84.
46. Sulejczak D, Grieb P, Walski M, Frontczak-Baniewicz M. Apoptotic death of cortical neurons following surgical brain injury. Folia Neuropathol 2008;46:213-219.
47. Takeuchi T. Pathology of Minamata disease. With special reference to its pathogenesis. Acta Pathol Jpn 1982;32 Suppl 1:73-99.
48. Vendrell I, Carrascal M, Vilaró MT, Abián J, Rodríguez-Farré E, Suñol C. Cell viability and proteomic analysis in cultured neurons exposed to methylmercury. Hum Exp Toxicol 2007;26:263-272.
49. Yel L, Brown LE, Su K, Gollapudi S, Gupta S. Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosisinducing factor release from mitochondria. Int J Mol Med 2005;16:971-977.
50. Yin Z, Milatovic D, Aschner JL, Syversen T, Rocha JB, Souza DO, Sidoryk M, Albrecht J, Aschner M. Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes. Brain Res 2007;1131:1-10.
51. Young H, Geier D, Geier M. Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink. J Neurol Sci 2008;271:110-118.
52. Zieminska E, Toczylowska B, Stafiej A, Lazarewicz JW. Low molecular weight thiols reduce thimerosal neurotoxicity in vitro: Modulation by proteins. Toxicology 2010;276:154-163.