Cyclosporine inhibits profibrotic effects of interleukin-4 and transforming growth factor β on human intrahepatic fibroblasts cultured in vitro

Transplantation Proceedings

Volumn 42, Issue 10, 2010, Pages 4343-4346

  Pissaia Jr , A ^a   Aoudjehane, L ^a   Ben Othman, S ^a   Scatton, O ^b   Soubrane, O ^b   Housset, C ^a   Calmus, Y ^a,c   Conti, F ^a,b,c  

^a CENTRE DE RECHERCHE SAINT ANTOINE   (France)

^b HÔPITAL SAINT ANTOINE   (France)

^c Institut de Virologie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; CYCLOSPORIN A; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA;

CELL ACTIVATION; CELL CULTURE; CELL ISOLATION; CLINICAL EVALUATION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; FIBROBLAST; FIBROGENESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER FIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

CELLS, CULTURED; COLLAGEN; CYCLOSPORINE; FIBROBLASTS; FIBROSIS; HUMANS; INTERLEUKIN-4; LIVER; TRANSFORMING GROWTH FACTOR BETA;

EID: 78650485149     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2010.09.124     Document Type: Conference Paper

References (20)

1. T. Kisseleva, and D.A. Brenner Hepatic stellate cells and the reversal of fibrosis J Gastroenterol Hepatol 21 2006 S84
2. J.P. Iredale Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ J Clin Invest 117 2007 539
3. R. Battaler, and D.A. Brenner Liver fibrosis J Clin Invest 115 2005 209
4. A.M. Gressner Proliferation and transformation of cultured liver fat storing cells perisinusoidal lipocytes under conditions of β-D- xylosideinduced abrogation of proteoglycan synthesis Exp Mol Pathol 55 1991 143
5. S. Lotersztajn, B. Julien, and F. Teixeira-Clerc Hepatic fibrosis: molecular mechanisms and drug targets Annu Rev Pahrmacol Toxicol 45 2005 605
6. S.L. Friedman Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury J Biol Chem 275 2000 2247
7. A. Kornberg, B. Kupper, and A. Tannapfel Impact of mycophenolate mofetil versus azathioprine on early recurrence of hepatitis C after liver transplantation Int Immunopharmacol 5 2005 107
8. M. Berenguer, F.X. Lpez-Labrador, and T.L. Wright Hepatitis C and liver transplantation J Hepatol 35 2001 666
9. S. Dharancy, P. Podevin, and L. Aoudjehane Elevated interleukin-4 expression in severe recurrent hepatitis C virus after liver transplantation Transplantation 83 2007 906
10. L. Cisneros, M.C. Londono, and C. Blasco Hepatic stellate cell activation in liver transplant patients with hepatitis C recurrence and in non-transplanted patients with chronic hepatitis C Liver Transpl 13 2007 1017
11. M. Berenguer, A. Royuela, and J. Zamora Immunosuppression with calcineurin inhibitors with respect to the outcome of HCV recurrence after liver transplantation: results of a meta-analysis Liver Transpl 13 2007 21
12. M. Berenguer, M. Prieto, and F. San Juan Contribution of donor age to the recent decrease in patient survival among HCV-infected liver transplant recipients Hepatology 36 2002 202
13. A. Pissaia Jr, L. Aoudjehane, and O. Scatton In vitro evaluation of the role of immunosuppressive therapy on liver fibrogenesis Am J Transplant 9 2009 s699
14. L. Aoudjehane, A. Pissaia Jr, and O. Scatton Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway Lab Invest 88 2008 973
15. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta (Ct)) method Methods 25 2001 402
16. M. Berenguer, M. Prieto, and A. Palau Recurrent hepatitis C genotype 1b following liver transplantation: treatment with combination interferon-ribavirin therapy Eur J Gastroenterol Hepatol 16 2004 1207
17. H. Ikeda, and K. Fujiwara Cyclosporin A and FK-506 in inhibition of rat Ito cell activation in vitro Hepatology 21 1995 1161
18. M. Nakamuta, M. Kohjima, and M. Fukushima Cyclosporine suppresses cell growth and collagen production in hepatic stellate cells Transplant Proc 37 2005 4598
19. K. Watashi, M. Hijikata, and M. Hosaka Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes Hepatology 38 2003 1282
20. S. Fan, and C.F. Weng Co-administration of cyclosporine A alleviates thioacetamide-induced liver injury World J Gastroenterol 11 2005 1411