Protective effects of Phyllanthus amarus on fibrotic markers during alcohol and polyunsaturated fatty acid-induced toxicity

Toxicology Mechanisms and Methods

Volumn 21, Issue 1, 2011, Pages 48-52

  Surya Narayanan, B ^a   Latha, P ^a   Rukkumani, R ^a  

^a Pondicherry University   (India)

Author keywords

Hepatic fibrosis; Matrix metalloproteinase; Phyllanthus amarus; Tissue inhibitors of matrix metalloproteinase

Indexed keywords

ALCOHOL; COLLAGEN; MATRIX METALLOPROTEINASE; PHYLLANTHUS AMARUS EXTRACT; POLYUNSATURATED FATTY ACID; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ALCOHOL OXIDATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; FATTY ACID OXIDATION; LIVER FIBROSIS; LIVER PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT;

ANIMALS; BIOLOGICAL MARKERS; COLLAGEN; ETHANOL; FATTY ACIDS, UNSATURATED; HYDROXYPROLINE; LIVER CIRRHOSIS; MALE; PHYLLANTHUS; PLANT EXTRACTS; RATS;

PHYLLANTHUS AMARUS; RATTUS; RATTUS NORVEGICUS;

EID: 78650450155     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2010.529189     Document Type: Article

References (26)

1. Ambili M, Radhakrishna PM, Sudhakaran PR. 1997. Characteristics of 60 K gela-tinase involved in rat mammary gland involution. Ind J Biochem Biophys 34:347-353.
2. Ambili M, Sudhakaran PR. 1998. Assay of matrix metalloproteinases in substrate impregnated gels in multiwells. Ind J Biochem Biophys 35:317-320.
3. Arthur MJP. 1995. Collagenases and liver fbrosis. J Hepatol 22:43-48.
4. Arthur MJP. 1997. Matrix degradation in liver: a role in injury and repair. J Hepatol 26:1069-1071.
5. Benyon RC, Arthur MJ. 2001. Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liv Dis 21:373-384.
6. Bissel DM. 1998. Hepatic fbrosis as wound-a progress report. J Gastroenterol 33:295-302.
7. Boeker KHW, Haberkorn CI, Michels D, Flemming P, Manns MP, Lichtinghagen R. 2002. Diagnostic potential of circulating TIMP-1 and MMP-2 as markers of liver fbrosis in patients with chronic hepatitis C. J Clin Chim Acta 316:71-81.
8. Brenner DA, Chojkier M. 1987. Acetaldehyde increases collagen gene transcription in cultured human fbroblasts. J Biol Chem 262:17690-17695.
9. Burt AD. 1993. Cellular and molecular aspects of hepatic fbrosis. J Pathol 170:105-114.
10. Di Sario A, Bendia E, Macarri G, Candelaresi C, Tafetani S, Marzioni M, Omenetti A, De Minicis S, Trozzi L, Benedetti A. 2004. Te antifbrotic efect of pirfenidone in rat liver fbrosis is mediated by down regulation of (α1) I, Timp-1 and MMP-2. J. Dig Liv Dis 36:744-751.
11. Eddy NO, Ekop AS. 2007. Phytoremediation potentials of some Nigerian weeds. Asian J Chem 19:1825-1831.
12. Guha G, Rajkumar V, Ashok Kumar R, Mathew L. 2010. Aqueous extract of Phyllanthus amarus inhibits chromium(VI)-induced toxicity in MDA-MB-435S cells. Food Chem Toxicol 48:396-401.
13. Iype T, Jayasree K, Sudhakaran PR. 2001. Modulation of alpha2 beta1 integrin changes during mammary gland development by beta-oestradiol. Biochim Biophys Acta 1499:232-241.
14. Kritikar KR, Basu BD. 1975. Indian medicinal plants, vol. 1. 2nd ed. Allahabad: Lalit Mohan Babu & Co. pp 2225.
15. Nagase H, Woessner JF. 1999. Matrix metalloproteinases. J Biol Chem 274:21491-21494.
16. Nanji AA, Zhao S, Sadzadeh SMH, Dannenberg AJ, Tahan SR, Waxman DJ. 1994. Markedly enhanced cytochrome P4502E1 induction and lipid peroxida-tion is associated with severe liver injury in fsh oil ethanol fed rat. Alc Clin Exp Res 18:1280-1285.
17. Nie QH, Duan GR, Luo XD, Xie, YM, Luo H, Zhou YX, Pan BR. 2004. Expression of TIMP-1 and TIMP-2 in rats with hepaic fbrosis. World J Gastroenterol 10:86-90.
18. Nieto N, Friedman SL, Greenwel P, Cederbaum AI. 1999. CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. J Hepatol 30:987-996.
19. Olaso E, Friedman SL. 1998. Molecular regulation of hepatic fbrogenesis. J Hepatol 29:836-847.
20. Rajesh Kumar NV, Joy KL, Girija K, Ramasewak RS, Nair MG, Ramadasan K. 2002. Anti tumor and anticarcogenic activity of phyllanthus amarus extract. J Ethnopharmacol 81,17-22.
21. Subir KD, Balakrishnan V, Vasudevan DM. 2006. Alcohol its health and impact in India. J Natl Med of Ind, 19, 94-99.
22. Suresh VP, Aruna K, Rukkumani R, Venugopal PM. 2006. Changes in activities of MMPs in alcohol and thermally oxidized sunfower oil induced damage: NAC antioxidant therapy. J Toxicol Mech and Meth 16, 267-274.
23. Watanabe T, Niioka M, Hozawa S, Kameyama K, Hayashi T, Arai M, Ishikawa A, Maruyama K, Okazaki T. 2000. Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fbrosis induced by carbon tetrachloride, J. Hepatol 33:224-235.
24. Vieira RF. 1999. Conservation of medicinal and aromatic plants in Brazil. p. 152-159. In: J. Janick (ed.), Perspectives on new crops and new uses. ASHS Press, Alexandria, VA.
25. Wang Z, Juttermann R, Soloway PD. 2000. TIMP-2 is required for efcient activation of Pro MMP-2 in vivo. J Biol Chem 275:26411-26415.
26. Woessner JF. 1961. Te determination of hydroxy proline in tissues and protein samples containing small proproteins of these amino acids. Arch Biochem Biophys 93:440-447.