Clinical profile and outcome of patients hospitalized with dimethyl and diethyl organophosphate poisoning

Clinical Toxicology

Volumn 48, Issue 9, 2010, Pages 916-923

  Peter, John Victor ^a   Jerobin, Jayakumar ^a   Nair, Anupama ^a   Bennett, Anjana ^a   Samuel, Prasanna ^a   Chrispal, Anugrah ^a   Abraham, Ooriapadickal Cherian ^a   Mathews, Kuruvilla Prasad ^a   Fleming, Jude Joseph ^a   Oommen, Anna ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Diethyl organophosphate; Dimethyl organophosphate; Intermediate syndrome; Outcome; Poisoning; Ventilation

Indexed keywords

ATROPINE; CHOLINESTERASE; DIETHYL ORGANOPHOSPHATE; DIMETHYL ORGANOPHOSPHATE; ORGANOPHOSPHATE PESTICIDE; UNCLASSIFIED DRUG;

ARTICLE; ARTIFICIAL VENTILATION; HUMAN; INTOXICATION; LENGTH OF STAY; MORTALITY; PROGNOSIS; TREATMENT DURATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ATROPINE; FEMALE; HOSPITAL MORTALITY; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; PHOSPHORIC ACID ESTERS; RESPIRATION, ARTIFICIAL; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 78650450146     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2010.528425     Document Type: Article

References (13)

1. Peter JV, Moran JL, Graham PL. Advances in the management of organophosphate poisoning. Expert Opin Pharmacother 2007; 8:1451-1464.
2. Eddleston M, Worek F, Eyer P, Thiermann H, von Meyer L, Jeganathan K, et al. Poisoning with the S-alkyl organophosphorus insecticides profenofos and prothiofos. QJM 2009; 102:785-792.
3. Eddleston M, Eyer P, Worek F, Mohamed F, Senarathna L, von Meyer L, et al. Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study. Lancet 2005; 366:1452-1459.
4. Peter JV, Jerobin J, Bennett A. Is there a relationship between the WHO hazard classification of organophosphate pesticide and outcomes in suicidal human poisoning with commercial organophosphate formulations? Regul Toxicol Pharmacol 2010; 57:99-102.
5. Vale JA. Toxicokinetic and toxicodynamic aspects of organopho-sphorus (OP) insecticide poisoning. Toxicol Lett 1998; 102-103:649-652.
6. Kwong TC. Organophosphate pesticides: biochemistry and clinical toxicology. Ther Drug Monitor 2002; 24:144-149.
7. Johnson S, Peter JV, Thomas K, Jeyaseelan L, Cherian AM. Evaluation of two treatment regimens of pralidoxime (1 gm single bolus dose vs. 12 gm infusion) in the management of organopho-sphorus poisoning. J Assoc Physicians India 1996; 44:529-531.
8. Cherian AM, Peter JV, Jayadevan R, Thomas K, Jeyaseelan L. Effectiveness of P2AM (PAM - pralidoxime) in the treatment of organophosphours (OPP) poisoning. A randomised double blind placebo controlled clinical trial. J Assoc Physicians India 1997; 45:22-24.
9. Pichamuthu K, Jerobin J, Nair A, John G, Kamalesh J, Thomas K, et al. Bioscavenger therapy for organophosphate poisoning; an open-labeled pilot randomized trial comparing fresh frozen plasma or albumin with saline in acute organophosphate poisoning in humans. Clin Toxicol (Phila) 2010, October 6, [Epub ahead of print].
10. Lin TJ, Walter FG, Hung DZ, Tsai JL, Hu SC, Chang JS, et al. Epidemiology of organophosphate pesticide poisoning in Taiwan. Clin Toxicol (Phila) 2008; 46:794-801.
11. Li H, Schopfer LM, Nachon F, Froment M-T, Masson P, Lockridge O. Aging pathways for organophosphate-inhibited human butyrylcholines-terase including novel pathways for isomalathion, resolved by mass spectroscopy. Toxicol Sci 2007; 100:136-145.
12. Benfenati E, Gini G, Piclin N, Roncaglioni A, Vari MR. Predicting logP of pesticides using different software. Chemosphere 2003; 53:1155-1164.
13. Sudarsanam TD, Pichaimuthu K, Zachariah A, John G. Oximes in acute organophosphate poisoning. Crit Care Med 2006; 34:2265.