Nitric oxide synergistically potentiates interleukin-1β-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: Involvement of cGMP-independent mechanisms

Neuropharmacology

Volumn 43, Issue 5, 2002, Pages 868-876

  Morioka, N ^a   Inoue, A ^a   Hanada, T ^a   Kumagai, K ^a   Takeda, K ^a   Ikoma, K ^a   Hide, I ^a   Tamura, Y ^b   Shiomi, H ^b   Dohi, T ^a   Nakata, Y ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b FUKUYAMA UNIVERSITY   (Japan)

Author keywords

cGMP independent pathway; Cyclooxygenase 2; Dorsal root ganglion cells; Nitric oxide; NO donor; Substance P

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; CYCLIC GMP; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GUANYLATE CYCLASE INHIBITOR; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; RECOMBINANT INTERLEUKIN 1BETA; SUBSTANCE P;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; HYPERALGESIA; INCUBATION TIME; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE; SPINAL GANGLION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CULTURE MEDIA; CYCLIC GMP; CYCLOOXYGENASE 2; DRUG SYNERGISM; ENZYME INDUCTION; GANGLIA, SPINAL; INTERLEUKIN-1; ISOENZYMES; NEURONS, AFFERENT; NITRIC OXIDE; NITRIC OXIDE DONORS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR; RNA, MESSENGER; S-NITROSO-N-ACETYLPENICILLAMINE; SUBSTANCE P; UP-REGULATION;

EID: 0036802920     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00143-0     Document Type: Article

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