Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro

Fertility and Sterility

Volumn 95, Issue 1, 2011, Pages 461-463

  Zhao, Lu ^a,b   Li, Wei ^b   Han, Fengjuan ^b   Hou, Lihui ^b   Baillargeon, Jean Patrice ^c   Kuang, Haixue ^b   Wang, Yongyan ^d   Wu, Xiaoke ^b,d  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

^d INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

berberine; hyperandrogenism; insulin resistance; ovarian theca cells; Polycystic ovary syndrome

Indexed keywords

BERBERINE; DEXAMETHASONE; GLUCOSE; TESTOSTERONE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GLUCOSE TRANSPORT; HORMONE SYNTHESIS; IN VITRO STUDY; INSULIN RESISTANCE; NONHUMAN; OVARY POLYCYSTIC DISEASE; PATHOGENESIS; PRIORITY JOURNAL; THECA CELL;

BERBERINE; CELLS, CULTURED; DEXAMETHASONE; DRUG INTERACTIONS; FEMALE; GLUCOCORTICOIDS; GLUCOSE; HUMANS; HYPERANDROGENISM; INSULIN RESISTANCE; POLYCYSTIC OVARY SYNDROME; THECA CELLS;

EID: 78650414876     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2010.07.1090     Document Type: Article

References (19)

1. S. Franks, L.J. Webberberine, M. Goh, A. Valentine, D.M. White, and G.S. Conway Ovarian morphology is a marker of heritable biochemical traits in sisters with polycystic ovaries J Clin Endocrinol Metab 93 2008 3396 3402
2. A. Dunaif, and Medscape Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome - a reappraisal Nat Clin Pract Endocrinol Metab 4 2008 272 283
3. A. Dunaif Insulin resistance in women with polycystic ovary syndrome Fertil Steril 86 Suppl 1 2006 S13 S14
4. A.D. Coviello, S. Sam, R.S. Legro, and A. Dunaif High prevalence of metabolic syndrome in first-degree male relatives of women with polycystic ovary syndrome is related to high rates of obesity J Clin Endocrinol Metab 94 2009 4361 4366
5. X.K. Wu, S.Y. Zhou, J.X. Liu, P. Pöllänen, K. Sallinen, and M. Mäkinen Selective ovary resistance to insulin signaling in women with polycystic ovary syndrome Fertil Steril 80 2003 954 965
6. X. Wu, K. Sallinen, L. Anttila, M. Mäkinen, C. Luo, and P. Pöllänen Expression of insulin-receptor substrate-1 and -2 in ovaries from women with insulin resistance and from controls Fertil Steril 74 2000 564 572
7. J. Burén, H.X. Liu, J. Jensen, and J.W. Eriksson Dexamethasone impairs insulin signaling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes Eur J Endocrinol 146 2002 419 429
8. M.J. Saad, F. Folli, E. Araki, N. Hashimoto, P. Csermely, and C.R. Kahn Regulation of insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and dexamethasone Mol Endocrinol 8 1994 545 557
9. S.H. Leng, F.E. Lu, and L.J. Xu Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion Acta Pharmacol Sin 25 2004 496 502
10. J. Qu, Y. Wang, X. Wu, L. Gao, L. Hou, and R. Erkkola Insulin resistance directly contributes to androgenic potential within ovarian theca cells Fertil Steril 91 2009 1990 1997
11. M. Yan, J. Wang, X. Wu, L. Hou, H. Kuang, and Y. Wang Induction of insulin resistance by phosphatidylinositol-3-kinase inhibitor in porcine granulosa cells Fertil Steril 92 2009 2119 2121
12. T. Asagami, T.H. Holmes, and G. Reaven Differential effects of insulin sensitivity on androgens in obese women with polycystic ovary syndrome or normal ovulation Metabolism 57 2008 1355 1360
13. J. Hirshfeld-Cytron, R.B. Barnes, D.A. Ehrmann, A. Caruso, M.M. Mortensen, and R.L. Rosenfield Characterization of functionally typical and atypical types of polycystic ovary syndrome J Clin Endocrinol Metab 94 2009 1587 1594
14. T.C. Lee, and W.L. Miller Auchus RJ Medroxyprogesterone acetate and Dexamethasone are competitive inhibitors of different human steroidogenic enzymes J Clin Endocrinol Metab 84 1999 2104 2110
15. J. Jager, T. Grémeaux, M. Cormont, Y. Le Marchand-Brustel, and J.F. Tanti Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression Endocrinology 148 2007 241 251
16. N.E. Zanchi, M.A. Filho, V. Felitti, H. Nicastro, F.M. Lorenzeti, and A.H. Lancha Jr. Glucocorticoids: extensive physiological actions modulated through multiple mechanisms of gene regulation J Cell Physiol 224 2010 311 315
17. M. Zhang, X.Y. Lv, J. Li, Z.G. Xu, and L. Chen The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model Exp Diabetes Res 2008 2008 7040 7045
18. W.C. Chen, S. Hayakawa, T. Yamamoto, H.C. Su, I.M. Liu, and J.T. Cheng Mediation of beta-endorphin by the isoflavone puerarin to lower plasma glucose in streptozotocin-induced diabetic rats Planta Med 70 2004 113 116
19. L.Q. Tang, W. Wei, L.M. Chen, and S. Liu Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats J Ethnopharmacol 108 2006 109 115