Modeling bioprocess cost: Process economic benefits of expression technology based on Pseudomonas fluorescens

BioProcess International

Volumn 8, Issue 10, 2010, Pages 62-70

  Lim, Janice A C ^a   Patkar, Anant ^b   McDonagh, Gráinne ^a   Sinclair, Andrew ^a   Lucy, Patrick ^b  

^a BioPharm Services UK   (United Kingdom)

^b Pfenex Inc   (United States)

Author keywords

Cost modeling; Cost of goods (CoG); Expression systems; Process economics; Process yield

Indexed keywords

ARTICLE; BIOPROCESS; BIOREACTOR; COMPUTER AIDED DESIGN; COMPUTER PROGRAM; COST BENEFIT ANALYSIS; ECONOMIC ASPECT; FERMENTATION; METHODOLOGY; NONHUMAN; PHARMACEUTICS; PROTEIN AGGREGATION; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PSEUDOMONAS FLUORESCENS; ROBOTICS; TECHNOLOGY;

PSEUDOMONAS FLUORESCENS;

EID: 78650406036     PISSN: 15426319     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (15)

1. Chadd HE, Chamow SM. Therapeutic Antibody Expression Technology. Curr. Opin. Biotechnol. 12(2) 2001: 188-194.
2. Kelly BD. Biochemical Engineering Bioprocessing of Therapeutic Proteins. Curr. Opin. Biotechnol. 12(2) 2001: 173-174.
3. Wurm FM. Manufacture of Recombinant Biopharmaceutical Proteins By Cultivated Mammalian Cells in Bioreactors. Modern Biopharmaceuticals. Knablein J, Ed. Wiley-VCH: Weinheim, Germany, 2005: 723-759.
4. Hacker DL, de Jesus M, Wurm FM. 25 Years of Recombinant Proteins from Reactor-Grown Cells: Where Do We Go from Here? Biotechnol. Adv. 27(6) 2009: 1023-1027.
5. Demain AL, Vaishnav P. Production of Recombinant Proteins By Microbes and Higher Organisms. Biotechnol. Adv. 27(3) 2009: 297-306.
6. Choi JH, Keum KC, Lee SY. Production of Recombinant Proteins By High Cell Density Culture of Escherichia coli. Chem. Eng. Sci. 61(3) 2006: 876-885.
7. Squires CH, Lucy P. Vendor Voice: A New Paradigm for Bacterial Strain Engineering. BioProcess Int. 6(4) 2008: S22-S27.
8. Chew LC, et al. Pseudomonas fluorescens (Chapter Three). Production of Recombinant Proteins: Novel Microbial and Eucaryotic Expression Systems. Gellissen G, Ed. Wiley: Hoboken, NJ, February 2005: 45-66.
9. Evans LB, Field RP. Bioprocess Simulation: A New Tool for Process Development. Chem. Eng. Australia 14(4) 1989.
10. Petrides DP. Biopro Designer: An Advanced Computing Environment for Modeling and Design of Integrated Biochemical Processes. Computers Chem. Eng. 18, 1994: S621-S625.
11. Farid S. Process Economics of Industrial Monoclonal Antibody Manufacture. J. Chromatog. B 848, 2007: 8-18.
12. Mora J, et al. Disposable Membrane Chromatography: Performance Analysis and Economic Cost Model. BioProcess Int. 4(6) 2006: S38-S43.
13. Lim JAC, et al. Economic Benefits of Single-Use Membrane Chromatography in Polishing: A Cost of Goods Model. BioProcess Int. 5(2) 2007: 48-56.
14. Kunert R, Gash J, Katinger H. Expression of a Fab Fragment in CHO and Pichia pastoris. BioProcess Int. 6(6) 2008: S34-S40.
15. Julien C. Production of Humanlike Recombinant Proteins in Pichia pastoris: From Expression Vector to Fermentation Strategy. BioProcess Int. January 4(1) 2006: 22-31.