A comparison of short-term exposure of once-daily extended release tacrolimus and twice-daily cyclosporine on renal function in healthy volunteers

Transplantation

Volumn 90, Issue 11, 2010, Pages 1185-1191

  Zaltzman, Jeffrey S ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Nephrotoxicity; Renal physiology; Tacrolimus

Indexed keywords

CYCLOSPORIN; TACROLIMUS;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DRUG EXPOSURE; DRUG FORMULATION; DRUG MONITORING; DRUG RELEASE; DRUG TARGETING; FEMALE; FLUID INTAKE; FOOD INTAKE; HUMAN; KIDNEY FUNCTION; MALE; OPEN STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SYSTOLIC BLOOD PRESSURE;

ADULT; BLOOD PRESSURE; CALCINEURIN; CANADA; CROSS-OVER STUDIES; CYCLOSPORINE; DELAYED-ACTION PREPARATIONS; DRUG ADMINISTRATION SCHEDULE; GLOMERULAR FILTRATION RATE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; MALE; PROSPECTIVE STUDIES; RENAL PLASMA FLOW, EFFECTIVE; TACROLIMUS; TIME FACTORS; YOUNG ADULT;

EID: 78650405317     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181fa4e77     Document Type: Article

References (35)

1. Myers BD, Ross J, Newton L, et al. Cyclosporine-associated chronic nephropathy. N Engl J Med 1984; 311: 699.
2. Ojo AO, Held PJ, Port FK, et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med 2003; 349: 931.
3. Zaltzman JS, PeiY, MaurerJ, et al. Cyclosporine nephrotoxicity inlung transplant recipients. Transplantation 1992; 54: 875.
4. Nankivell BJ, Chapman JR. Chronic allograft nephropathy: Current concepts and future directions. Transplantation 2006; 8: 643.
5. Pei Y, Chan C, Cattran D, et al. Sustained vasoconstriction associated with daily cyclosporine dose in heart and lung transplant recipients: Potential pathophysiologic role of endothelin. J Lab Clin Med 1995; 125: 113.
6. Klein IH, Abrahams A, van Ede T, et al. Different effects of tacrolimus and cyclosporine on renal hemodynamics and blood pressure in healthy subjects. Transplantation 2002; 73: 732.
7. Nankivell BJ, Chapman JR, Bonovas G, et al. Oral cyclosporine but not tacrolimus reduces renal transplant blood flow. Transplantation 2004; 77: 1457.
8. Tantravahi J, Womer KL, Kaplan B. Why hasn't eliminating acute rejection improved graft survival? Annu Rev Med 2007; 58: 369.
9. Meier-Kriesche HU, Schold JD, Kaplan B. Long-term renal allograft survival: Have we made significant progress or is it time to rethink our analytic and therapeutic strategies? Am J Transplant 2004; 4: 1289.
10. Alloway R, Steinberg S, Khalil K, et al. Two years postconversion from a prograf-based regimen to a once-daily tacrolimus extended-release formulation in stable kidney transplant recipients. Transplantation 2007; 83: 1648.
11. Andreoni KA, Brayman KL, Guidinger MK, et al. Kidney and pancreas transplantation in the united states, 1996-2005. Am J Transplant 2007; 7: 1359.
12. Calne RY, White DJ, Thiru S, et al. Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet 1978; 2: 1323.
13. Murray BM, Paller MS, Ferris TF. Effectof cyclosporine administration on renal hemodynamics in conscious rats. Kidney Int 1985; 28: 767.
14. Curtis JJ, Laskow DA. Cyclosporine-induced nephrotoxicity: Patho-physiology of decreased blood flow. Transplant Proc 1988; 20: 540.
15. Fuiano G, Conte G, Sepe V, et al. Acute effects of ciclosporin on renal hemodynamics and urinary protein excretion in patients with the ne-phrotic syndrome. Nephron 1991; 59: 369.
16. Bagnis C, Deray G, Dubois M, et al. Comparative acute nephrotoxicity of FK-506 and ciclosporin in an isolated in situ autoperfused rat kidney model. Am J Nephrol 1997; 17: 17.
17. Perico N, Ruggenenti P, Gaspari F, et al. Daily renal hypoperfusion induced by cyclosporine in patients with renal transplantation. Transplantation 1992; 54: 56.
18. Heffron TG, Pescovitz MD, Florman S, et al. Once-daily tacrolimus extended-release formulation: 1-year post-conversion in stable pediat-ric liver transplant recipients. Am J Transplant 2007; 7: 1609.
19. Ekberg H, Tedesco-Silva H, Demirbas A, et al. Reduced exposure to cal-cineurin inhibitors in renal transplantation. N Engl J Med 2007; 357: 2562.
20. Kung L, Batiuk TD, Palomo-Pinon S, et al. Tissue distribution of cal-cineurin and its sensitivity to inhibition by cyclosporine. Am J Transplant 2001; 1: 325.
21. Halloran PF, Helms LM, Kung L, et al. The temporal profile of calcineurin inhibition by cyclosporine in vivo. Transplantation 1999; 68: 1356.
22. Lee DB. Cyclosporine and the renin-angiotensin axis. Kidney Int 1997; 52: 248.
23. Kurtz A, Della Bruna R, Kühn K. Cyclosporine A enhances renin secretion and production in isolated juxtaglomerular cells. Kidney Int 1988; 33: 947.
24. Cauduro RL, Costa C, Lhulier F, et al. Cyclosporine increases endothelin-1 plasma levels in renal transplant recipients. Transplant Proc 2004; 36: 880.
25. Perico N, Dadan J, Remuzzi G. Endothelin mediates the renal vasocon-striction induced by cyclosporine in the rat. J Am Soc Nephrol 1990; 1: 76.
26. Nankivell BJ, Borrows RJ, Fung CL,et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003; 349: 2326.
27. Naesens M, Kuypers DR, Sarwal M. Calcineurin inhibitor nephrotox-icity. Clin J Am Soc Nephrol 2009; 4: 481.
28. El-Zoghby ZM, Stegall MD, Lager DJ, et al. Identifying specific causes of kidney allograft loss. Am J Transplant 2009; 9: 527.
29. Gaston RS. Chronic calcineurin inhibitor nephrotoxicity: Reflections on an evolving paradigm. Clin J Am Soc Nephrol 2009; 4: 2029.
30. Einecke G, Sis B, Reeve J, et al. Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. Am J Transplant 2009; 9: 2520.
31. Servais A, Meas-Yedid V, Toupance O, et al. Interstitial fibrosis quantification in renal transplant recipients randomized to continue cyclo-sporine or convert to sirolimus. Am J Transplant 2009; 9: 2552.
32. Lucey MR, Abdelmalek MF, Gagliardi R, et al. A comparison of tacroli-mus and cyclosporineinliver transplantation: Effects on renal function and cardiovascular risk status. Am J Transplant 2005; 5: 1111.
33. Jurewicz WA. Tacrolimus versus cyclosporin immunosuppression: Long-term outcome in renal transplantation. Nephrol Dial Transplant 2003; 18: 7.
34. Kaplan B, Schold JD, Meier-Kriesche HU. Long-term graft survival with neoral and tacrolimus: A paired kidney analysis. J Am Soc Nephrol 2003; 14: 2980.
35. Ekberg H, Bernasconi C, Tedesco-Silva H, et al. Calcineurin inhibitor minimization in the symphony study: Observational results 3 years after transplantation. Am J Transplant 2009; 9: 1876.