Treatment of acute ischemic stroke in patients with cerebral microbleeds: A decision analysis

QJM: An International Journal of Medicine

Volumn 104, Issue 1, 2011, Pages 73-82

  Benbassat, J ^a   Baumal, R ^b   Herishanu, Y ^c  

^a MYERS JDC BROOKDALE INSTITUTE   (Israel)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; HEPARIN;

ACUTE DISEASE; ACUTE ISCHEMIC STROKE; ANTICOAGULANT THERAPY; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBRAL MICROBLEED; CLINICAL DECISION MAKING; COMORBIDITY; DECISION TREE; DISEASE ASSOCIATION; DRUG EFFICACY; FATALITY; HUMAN; MEDLINE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RECURRENT DISEASE; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; SYSTEMATIC REVIEW;

EID: 78650391231     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcq119     Document Type: Article

References (67)

1. Dhamoon MS, Sciacca RR, Rundek T, Sacco RL, Elkind MS. Recurrent stroke and cardiac risks after first ischemic stroke: the Northern Manhattan Study. Neurology 2006; 66:641-6.
2. Hill MD, Yiannakoulias N, Jeerakathil T, Tu JV, Svenson LW, Schopflocher DP. The high risk of stroke immediately after transient ischemic attack. Neurology 2004; 62:2015-20.
3. Hankey GJ, Jamrozik K, Broadhurst RJ, Forbes S, Burvill PW, Anderson CS, et al. Long-term risk of first recurrent stroke in the Perth Community Stroke Study. Stroke 1998; 29:2491-500.
4. International Stroke Trial (IST) Collaborative Group. A randomized trial of aspirin, subcutaneous heparin, both or neither among 19,435 patients with acute ischemic stroke. Lancet 1997; 349:1569-81.
5. Acute Stroke Treatment (TOAST) Investigators. Low molecular weight heparinoid, ORG 10172 (danaparoid), and outcome after acute ischemic stroke: a randomized controlled trial. JAMA 1998; 279:1265-72.
6. Fiorelli M, Bastianello S, von Kummer R, del Zoppo GJ, Larrue V, Lesaffre E, et al. Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort. Stroke 1999; 30:2280-4.
7. Jaillard A, Cornu C, Durieux A, Moulin T, Boutitie F, Lees KR, et al. Hemorrhagic transformation in acute ischemic stroke. The MAST-E study. MAST-E Group. Stroke 1999; 30:1326-32.
8. Chen ZM, Sandercock P, Pan HC, Counsell C, Collins R, Liu LS, et al. Indications for early aspirin use in acute ischemic stroke: a combined analysis of 40,000 randomized patients from the chinese acute stroke trial and the international stroke trial. On behalf of the CAST and IST collaborative groups. Stroke 2000; 31:1240-9.
9. Berger C, Fiorelli M, Steiner T, Schabitz WR, Bozzao L, Bluhmki E, et al. Hemorrhegic Transformation of Ischemic Brain Tissue: Asymptomatic or Symptomatic? Stroke 2001; 32:1330-5.
10. Wardlaw JM. Overview of Cochrane thrombolysis meta-analysis. Neurology 2001; 57(Suppl. 2):S69-76.
11. Antithrombotic Trialists' Collaboration. Collaborative metaanalysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high risk patients. Br Med J 2002; 324:71-86.
12. Castellanos M, Leira R, Serena J, Pumar JM, Lizasoain I, Castillo J, et al. Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke 2003; 34:40-6.
13. Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, et al. ATLANTIS Trials Investigators; ECASS Trials Investigators; NINDS rt-PA Study Group Investigators. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004; 363:768-74.
14. Ariesen MJ, Algra A, Koudstaal PJ, Rothwell PM, van Walraven C. (AFASAK Trial Investigators; DTT Trial Investigators; PATAF Trial Investigators; EAFT Trial Investigators; SPAF Trial Investigators; SPIRIT Trial Investigators; UKTIA Trial Investigators). Risk of intracerebral hemorrhage in patients with arterial versus cardiac origin of cerebral ischemia on aspirin or placebo: analysis of individual patient data from 9 trials. Stroke 2004; 35:710-4.
15. Ehlers L, Andersen G, Clausen LB, Bech M, Kjolby M. Costeffectiveness of intravenous thrombolysis with alteplase within a 3-hour window after acute ischemic stroke. Stroke 2007; 38:85-9.
16. Meenan RT, Saha S, Chou R, Swarztrauber K, Pyle Krages K, O'Keeffe-Rosetti MC, et al. Cost-effectiveness of echocardiography to identify intracardiac thrombus among patients with first stroke or transient ischemic attack. Med Decis Making 2007; 27:161-77.
17. Cordonnier C, Al-Shahi Salman R, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007; 130:1988-2003.
18. Horowitz GL, Bleich HL. PaperChase: a computer program to search the medical literature. New Engl J Med 1981; 305:924-30.
19. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombtic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007; 146:857-67.
20. Sacco RL, Foulkes MA, Mohr JP, Wolf PA, Hier DB, Price TR. Determinants of early recurrence of cerebral infarction. Stroke 1989; 20: 983-9.
21. Sacco RL, Shi T, Zamanillo MC, Kargman DE. Risk indicators of mortality and recurrence after hospitalized cerebral infarction in an urban community: the Northern Manhattan Stroke Study. Neurology 1994; 44:626-34.
22. Moroney JT, Bagiella E, Paik MC, Sacco RL, Desmond DW. Risk factors for early recurrence after ischemic stroke: the role of stroke syndrome and subtype. Stroke 1998; 29:2118-24.
23. Petty GW, Brown RD, Whisnant JP, Sicks JD, O'Fallon WM, Wiebers DO, et al. Ischemic stroke subtypes. A population based study of functional outcome, survival and recurrence. Stroke 2000; 31:1062-8.
24. Kolominsky-Rabas PL, Weber M, Gefeller O, Neundorfer B, Heuschmann PU. Epidemiology of ischemic stroke subtypes according to the TOAST criteria. Stroke 2001; 32:2735-40.
25. Grau AJ, Weimar C, Buggle F, Heinrich A, Goertler M, Neumaier S, et al. Risk factors, outcome, and treatment in subtypes of ischemic stroke: the German stroke data bank. Stroke 2001; 32:2559-66.
26. Bang OY, Lee PH, Joo SY, Lee JS, Joo IS, Huh K. Frequency and mechanisms of stroke recurrence after cryptogenic stroke. Ann Neurol 2003; 54:227-34.
27. Lovett JK, Coull AJ, Rothwell PM. Early risk of recurrence by subtype of ischemic stroke in population-based incidence studies. Neurology 2004; 62:569-73.
28. Modrego PJ, Mainar R, Turull L. Recurrence and survival after first-ever stroke in the area of Bajo Aragon, Spain. A prospective cohort study. J Neurol Sci 2004; 224:49-55.
29. Soda T, Nakayasu H, Maeda M, Kusumi M, Kowa H, Awaki E, et al. Stroke recurrence within the first year following cerebral infarction- -Tottori University Lacunar Infarction Prognosis Study (TULIPS). Acta Neurol Scand 2004; 110:343-9.
30. Purroy F, Montaner J, Molina CA, Delgado P, Ribo M, Alvarez-Sabin J. Patterns and predictors of early risk of recurrence after transient ischemic attack with respect to etiologic subtypes. Stroke 2007; 38:3225-9.
31. Coutts SB, Hill MD, Campos CR, Choi YB, Subramaniam S, Kosior JC, et al. Recurrent events in transient ischemic attack and minor stroke: what events are happening and to which patients? Stroke 2008; 39:2461-6.
32. Fan YH, Zhang L, Lam WW, Mok VC, Wong KS. Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke. Stroke 2003; 34:2459-62.
33. Boulanger JM, Coutts SB, Eliasziw M, Gagnon AJ, Simon JE, Subramaniam S, et al. Cerebral microhemorrhages predict new disabling or fatal strokes in patients with acute ischemic stroke or transient ischemic attack. Stroke 2006; 37:911-4.
34. Naka H, Nomura E, Takahashi T, Wakabayashi S, Mimori Y, Kajikawa H, et al. Combinations of the presence or absence of cerebral microbleeds and advanced white matter hyperintensity as predictors of subsequent stroke types. AJNR Am J Neuroradiol 2006; 27:830-5.
35. Soo YO, Yang SR, Lam WW, Wong A, Fan YH, Leung HH, et al. Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds. J Neurol 2008; 255:1679-86.
36. Gubitz G, Sandercock P, Counsell C. Anticoagulants for acute ischaemic stroke. Cochrane Database Syst Rev 2004, issue 3. Art no CD000024, pub 2.
37. Paciaroni M, Agnelli G, Micheli S, Caso V. Efficacy and safety of anticoagulant treatment in acute ardioembolic stroke: a meta-analysis of randomized controlled trials. Stroke 2007; 38:423-30.
38. Nighoghossian N, Hermier M, Adeleine P, Blanc-Lasserre K, Derex L, Honnorat J, et al. Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: a gradient-echo T2*-weighted brain MRI study. Stroke 2002; 33:735-42.
39. Kidwell CS, Saver JL, Villablanca LP, Duckwiler G, Fredieu FV, Gough C, et al. Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application. Stroke 2002; 33:95-8.
40. Diringer MN, Edwards DF. Admission to a neurologic/neurosurgical intensive care unit ischemic stroke associated with reduced mortality rate after intracerebral hemorrhage. Crit Care Med 2001; 29:635-40.
41. Greenberg SM, Eng JA, Ning M, Smith EE, Rosand J. Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke 2004; 35:1415-20.
42. Jeon SB, Kang DW, Cho AH, Lee EM, Choi CG, Kwon SU, et al. Initial microbleeds at MR imaging can predict recurrent intracerebral hemorrhage. J Neurol 2007; 254:508-12.
43. Bath PM, Iddenden R, Bath FJ. Low-molecular-weight heparins and heparinoids in acute ischemic stroke: a meta-analysis of randomized controlled trials. Stroke 2000; 31:1770-8.
44. Foerch C, Sitzer M, Steinmetz H, Neumann-Haefelin T. Pretreatment with antiplatelet agents ischemic stroke not independently associated with unfavorable outcome in intracerebral hemorrhage. Stroke 2006; 37:2165-7.
45. Saloheimo P, Ahonen M, Juvela S, Pyhtinen J, Savolainen ER, Hillbom M. Regular aspirin-use preceding the onset of primary intracerebral hemorrhage ischemic stroke an independent predictor for death. Stroke 2006; 37:129-33.
46. Roquer J, Rodriguez Campello A, Gomis M, Ois A, Puente V, Munteis E. Previous antiplatelet therapy ischemic stroke an independent predictor of 30-day mortality after spontaneous supratentorial intracerebral hemorrhage. J Neurol 2005; 252:412-6.
47. Wong KS, Chan YL, Liu JY, Gao S, Lam WW. Asymptomatic microbleeds as a risk factor for aspirin-associated intracerebral hemorrhages. Neurology 2003; 60:511-3.
48. Rosand J, Eckman MH, Knudsen KA, Singer DE, Greenberg SM. The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Arch Intern Med 2004; 164:880-4.
49. Hartmann A, Rundek T, Mast H, Paik MC, Boden-Albala B, Mohr JP, et al. Mortality and causes of death after first ischemic stroke: the Northern Manhattan Stroke Study. Neurology 2001; 57:2000-5.
50. de Jong G, van Raak L, Kessels F, Lodder J. Stroke subtype and mortality. A follow-up study in 998 patients with a first cerebral infarct. J Clin Epidemiol 2003; 56:262-8.
51. Vernino S, Brown RD, Sejvar JJ, Sicks JD, Petty GW, O'Fallon WM. Cause-specific mortality after first cerebral infarction: a population-based study. Stroke 2003; 34:1828-32.
52. Weisman SM, Graham DY. Evaluation of the benefits and risks of low-dose aspirin in the secondary prevention of cardiovascular and cerebrovascular events. Arch Intern Med 2002; 162:2197-202.
53. Paciaroni M, Agnelli G, Corea F, Ageno W, Alberti A, Lanari A, et al. Early hemorrhagic transformation of brain infarction: rate, predictive factors, and influence on clinical outcome. Results of a Prospective Multicenter Study. Stroke 2008; 39:2249-56.
54. National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333:1581-7.
55. Kase CS, Furlan AJ, Wechsler LR, Higashida RT, Rowley HA, Hart RG, et al. PROACT II investigators. Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: the PROACT II trial. Neurology 2001; 57:1603-10.
56. Murat Sumer M, Erturk O. Ischemic stroke subtypes: risk factors, functional outcome and recurrence. Neurol Sci 2002; 22:449-54.
57. Lee SH, Bae HJ, Kwon SJ, Kim H, Kim YH, Yoon BW, et al. Cerebral microbleeds are regionally associated with intracerebral hemorrhage. Neurology 2004; 62:72-6.
58. Lee SH, Kim BJ, Roh JK. Silent microbleeds are associated with volume of primary intracerebral hemorrhage. Neurology 2006; 66:430-2.
59. Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Niessen WJ, Hofman A, et al. Prevalence and risk factors of cerebral microbleeds: the rotterdam scan study. Neurology 2008; 70:1208-14.
60. Lee SH, Kang BS, Kim N, Roh JK. Does microbleed predict haemorrhagic transformation after acute atherothroembolic or cardioembolic stroke? J Neurol Neurosurg Psychiatry 2008; 79:913-6.
61. Jeon SB, Kwon SU, Cho AH, Yun SC, Kim JS, Kang DW. Rapid appearance of new cerebral microbleeds after acute ischemic stroke. Neurology 2009; 73:1638-44.
62. Kim HS, Lee DH, Ryu CW, Lee JH, Choi CG, Kim SJ, et al. Multiple cerebral microbleeds in hyperacute ischemic stroke: impact on prevalence and severity of early hemorrhagic transformation after thrombolytic treatment. AJR Am J Roentgenol 2006; 186:1443-9.
63. Fiehler J, Albers GW, Boulanger JM, Derex L, Gass A, Hjort N, et al. Bleeding risk analysis in stroke imaging before thromboLysis (BRASIL): pooled analysis of T2*-weighted magnetic resonance imaging data from 570 patients. Stroke 2007; 38:2738-44.
64. Rosand J, Hylek EM, O'Donnell HC, Greenberg SM. Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study. Neurology 2000; 55:947-51.
65. Lee SH, Ryu WS, Roh JK. Cerebral microbleeds are a risk factor for warfarin-related intracerebral hemorrhage. Neurology 2009; 72:171-6.
66. Hirsh J, Guyatt G, Albers GW, Harrington R, Schunemann HJ. American College of Chest Physician. Antithrombotic and thrombolytic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133(6 Suppl):110S-2S.
67. Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Salman RA, Warach S, et al. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 2009; 8:165-74.