Stress-Induced and Cue-Induced Craving for Alcohol in Heavy Drinkers: Preliminary Evidence of Genetic Moderation by the OPRM1 and CRH-BP Genes

Alcoholism: Clinical and Experimental Research

Volumn 35, Issue 1, 2011, Pages 166-174

  Ray, Lara A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alcohol; Corticotrophin Releasing Hormone Binding Protein; Craving; Genetics; Mu Opioid Receptor; Stress

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; MU OPIATE RECEPTOR;

ADULT; ALCOHOLISM; ARTICLE; ASSOCIATION; FEMALE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IMAGERY; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STRESS; WITHDRAWAL SYNDROME;

ADULT; AFFECT; ALCOHOL DRINKING; ALCOHOLISM; ALLELES; BEHAVIOR, ADDICTIVE; CARRIER PROTEINS; CUES; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OPIOID, MU; REWARD; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 78650382438     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01333.x     Document Type: Article

References (58)

1. Allen JP, Litten RZ, Fertig JB, Babor T (1997) A review of research on the Alcohol Use Disorders Identification Test (AUDIT). Alcohol Clin Exp Res 21:613-619.
2. Anton RF, Drobes DJ, Voronin K, Durazo-Avizu R, Moak D (2004) Naltrexone effects on alcohol consumption in a clinical laboratory paradigm: temporal effects of drinking. Psychopharmacology (Berl) 173:32-40.
3. Arias A, Feinn R, Kranzler HR (2006) Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis. Drug Alcohol Depend 83:262-268.
4. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
5. Binder EB, Owens MJ, Liu W, Deveau TC, Rush AJ, Trivedi MH, Fava M, Bradley B, Ressler KJ, Nemeroff CB (2010) Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response. Arch Gen Psychiatry 67:369-379.
6. Bohn MJ, Krahn DD, Staehler BA (1995) Development and initial validation of a measure of drinking urges in abstinent alcoholics. Alcohol Clin Exp Res 19:600-606.
7. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, Tischfield JA, Kreek MJ, Yu L (1998) Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci USA 95:9608-9613.
8. Cohen J (1988) Statistical Power Analysis for the Social Sciences. Erlbaum, Hillsdale, NJ.
9. Cohen J (1992) A power primer. Psychol Bull 112:155-159.
10. Cooney NL, Litt MD, Morse PA, Bauer LO, Gaupp L (1997) Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men. J Abnorm Psychol 106:243-250.
11. Dar R, Serlin RC, Omer H (1994) Misuse of statistical test in three decades of psychotherapy research. J Consult Clin Psychol 62:75-82.
12. Enoch MA, Shen PH, Ducci F, Yuan Q, Liu J, White KV, Albaugh B, Hodgkinson CA, Goldman D (2008) Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. PLoS ONE 3:e3620.
13. Filbey FM, Ray L, Smolen A, Claus ED, Audette A, Hutchison KE (2008) Differential neural response to alcohol priming and alcohol taste cues is associated with DRD4 VNTR and OPRM1 genotypes. Alcohol Clin Exp Res 32:1113-1123.
14. Gauderman WJ (2002a) Sample size requirements for association studies of gene-gene interaction. Am J Epidemiol 155:478-484.
15. Gauderman WJ (2002b) Sample size requirements for matched case-control studies of gene-environment interaction. Stat Med 21:35-50.
16. Gauderman WJ (2003) Candidate gene association analysis for a quantitative trait, using parent-offspring trios. Genet Epidemiol 25:327-338.
17. Heilig M, Koob GF (2007) A key role for corticotropin-releasing factor in alcohol dependence. Trends Neurosci 30:399-406.
18. Heinrichs SC, Menzaghi F, Pich EM, Baldwin HA, Rassnick S, Britton KT, Koob GF (1994) Anti-stress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity. Neuropsychopharmacology 11:179-186.
19. Hernandez-Avila CA, Wand G, Luo X, Gelernter J, Kranzler HR (2003) Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1). Am J Med Genet B Neuropsychiatr Genet 118B:60-65.
20. Koob GF (2003) Alcoholism: allostasis and beyond. Alcohol Clin Exp Res 27:232-243.
21. Koob GF (2010) The role of CRF and CRF-related peptides in the dark side of addiction. Brain Res 1314:3-14.
22. Koob G, Kreek MJ (2007) Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry 164:1149-1159.
23. Kreek MJ (2008) Role of a functional human gene polymorphism in stress responsivity and addictions. Clin Pharmacol Ther 83:615-618.
24. Lang PJ (1979) Presidential address, 1978. A bio-informational theory of emotional imagery. Psychophysiology 16:495-512.
25. Lang PJ, Kozak MJ, Miller GA, Levin DN, McLean A Jr (1980) Emotional imagery: conceptual structure and pattern of somato-visceral response. Psychophysiology 17:179-192.
26. Litt MD, Cooney NL, Kadden RM, Gaupp L (1990) Reactivity to alcohol cues and induced moods in alcoholics. Addict Behav 15:137-146.
27. MacKillop J (2006) Factor structure of the alcohol urge questionnaire under neutral conditions and during a cue-elicited urge state. Alcohol Clin Exp Res 30:1315-1321.
28. Mackillop J, Menges DP, McGeary JE, Lisman SA (2007) Effects of craving and DRD4 VNTR genotype on the relative value of alcohol: an initial human laboratory study. Behav Brain Funct 3:11.
29. McNair DM, Lorr M, Droppleman LF (1971) Manual for the Profile of Mood States. Educational & Industrial Testing Service, San Diego.
30. Monti PM, Binkoff JA, Abrams DB, Zwick WR, Nirenberg TD, Liepman MR (1987) Reactivity of alcoholics and nonalcoholics to drinking cues. J Abnorm Psychol 96:122-126.
31. Monti PM, Rohsenow DJ, Swift RM, Gulliver SB, Colby SM, Mueller TI, Brown RA, Gordon A, Abrams DB, Niaura RS, Asher MK (2001) Naltrexone and cue exposure with coping and communication skills training for alcoholics: treatment process and 1-year outcomes. Alcohol Clin Exp Res 25:1634-1647.
32. Monti PM, Tidey J, Czachowski CL, Grant KA, Rohsenow DJ, Sayette M, Maners N, Pierre P (2004) Building bridges: the transdisciplinary study of craving from the animal laboratory to the lamppost. Alcohol Clin Exp Res 28:279-287.
33. Oroszi G, Anton RF, O'Malley S, Swift R, Pettinati H, Couper D, Yuan Q, Goldman D (2008) OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach. Alcohol Clin Exp Res 33:383-393.
34. Oslin DW, Berrettini W, Kranzler HR, Pettinati H, Gelernter J, Volpicelli JR, O'Brien CP (2003) A functional polymorphism of the mu-opioid receptor gene is associated with naltrexone response in alcohol-dependent patients. Neuropsychopharmacology 28:1546-1552.
35. Pratt WM, Davidson D (2009) Role of the HPA axis and the A118G polymorphism of the mu-opioid receptor in stress-induced drinking behavior. Alcohol Alcohol 44:358-365.
36. Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, Hommer D, Heilig M (2010) A genetic determinant of the striatal dopamine response to alcohol in men. Mol Psychiatry May 18 [Epub ahead of print].
37. Ray LA, Hutchison KE (2004) A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. Alcohol Clin Exp Res 28:1789-1795.
38. Ray LA, Hutchison KE (2007) Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study. Arch Gen Psychiatry 64:1069-1077.
39. Ray LA, Hutchison KE, Tartter M (2010a) Application of human laboratory models to pharmacotherapy development for alcohol dependence. Curr Pharm Des 16:2149-2158.
40. Ray LA, MacKillop J, Leventhal A, Hutchison KE (2009) Catching the alcohol buzz: an examination of the latent factor structure of subjective intoxication. Alcohol Clin Exp Res 33:2154-2161.
41. Ray LA, Miranda R Jr, Tidey JW, McGeary JE, MacKillop J, Gwaltney CJ, Rohsenow DJ, Swift RM, Monti PM (2010b) Polymorphisms of the mu-opioid receptor and dopamine D4 receptor genes and subjective responses to alcohol in the natural environment. J Abnorm Psychol 119:115-125.
42. Sinha R (2001) How does stress increase risk of drug abuse and relapse? Psychopharmacology (Berl) 158:343-359.
43. Sinha R (2007) The role of stress in addiction relapse. Curr Psychiatry Rep 9:388-395.
44. Sinha R (2008) Chronic stress, drug use, and vulnerability to addiction. Ann N Y Acad Sci 1141:105-130.
45. Sinha R (2009) Modeling stress and drug craving in the laboratory: implications for addiction treatment development. Addict Biol 14:84-98.
46. Sinha R, Fox HC, Hong KA, Bergquist K, Bhagwagar Z, Siedlarz KM (2009) Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology 34:1198-1208.
47. Sinha R, Fuse T, Aubin LR, O'Malley SS (2000) Psychological stress, drug-related cues and cocaine craving. Psychopharmacology (Berl) 152:140-148.
48. Sinha R, Lovallo WR, Parsons OA (1992) Cardiovascular differentiation of emotions. Psychosom Med 54:422-435.
49. Sobell LC, Brown J, Leo GI, Sobell MB (1996) The reliability of the Alcohol Timeline Followback when administered by telephone and by computer. Drug Alcohol Depend 42:49-54.
50. Spina MG, Basso AM, Zorrilla EP, Heyser CJ, Rivier J, Vale W, Merlo-Pich E, Koob GF (2000) Behavioral effects of central administration of the novel CRF antagonist astressin in rats. Neuropsychopharmacology 22:230-239.
51. Uhart M, Wand GS (2009) Stress, alcohol and drug interaction: an update of human research. Addict Biol 14:43-64.
52. Wand GS, McCaul M, Yang X, Reynolds J, Gotjen D, Lee S, Ali A (2002) The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade. Neuropsychopharmacology 26:106-114.
53. Wang B, Shaham Y, Zitzman D, Azari S, Wise RA, You ZB (2005) Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking. J Neurosci 25:5389-5396.
54. Wang B, You ZB, Rice KC, Wise RA (2007) Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology (Berl) 193:283-294.
55. Wiers RW, Rinck M, Dictus M, van den Wildenberg E (2009) Relatively strong automatic appetitive action-tendencies in male carriers of the OPRM1 G-allele. Genes Brain Behav 8:101-106.
56. van den Wildenberg E, Wiers RW, Dessers J, Janssen RG, Lambrichs EH, Smeets HJ, van Breukelen GJ (2007) A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers. Alcohol Clin Exp Res 31:1-10.
57. de Wit H, Soderpalm AH, Nikolayev L, Young E (2003) Effects of acute social stress on alcohol consumption in healthy subjects. Alcohol Clin Exp Res 27:1270-1277.
58. Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W (2005) Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem 280:32618-32624.