Determination of antihyperglycemic biguanides in serum and urine using an ion-pair solid-phase extraction technique followed by HPLC-UV on a pentafluorophenylpropyl column and on an octadecyl column

Biomedical Chromatography

Volumn 20, Issue 11, 2006, Pages 1200-1205

  Tahara, Kayoko ^a   Yonemoto, Ayumi ^a   Yoshiyama, Yuji ^a   Nakamura, Toshiya ^a   Aizawa, Masaaki ^b   Fujita, Yoshikuni ^c   Nishikawa, Takashi ^a  

^a KEIO UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY HOSPITAL   (Japan)

^c KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Buformin; HPLC UV; Ion pair solid phase extraction; Metformin; Pentafluorophenylpropyl column

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; DRUG PRODUCTS; EXTRACTION; IONS; PHASE SEPARATION;

BIOLOGICAL FLUIDS; BUFORMIN; HPLC-UV; ION-PAIR SOLID-PHASE EXTRACTIONS; METFORMINS; OCTADECYL COLUMNS; PENTAFLUOROPHENYLPROPYL; PENTAFLUOROPHENYLPROPYL COLUMN; SOLID PHASE EXTRACTION CARTRIDGES; SOLID PHASE EXTRACTION TECHNIQUES;

RECOVERY;

BIGUANIDE DERIVATIVE; BUFORMIN; DODECYL SULFATE; METFORMIN;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION PAIR EXTRACTION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SOLID PHASE EXTRACTION; ULTRAVIOLET RADIATION;

EID: 33751110456     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.685     Document Type: Article

References (15)

1. AbuRuz S, Millership J and McElnay J. Determination of metformin in plasma using a new ion pair solid-phase extraction technique and ion pair liquid chromatography. Journal of Chromatography B 2003; 798: 203.
2. Bonfigli RA, Manfrini S, Gregorio F, Testa R, Testa I, De Sio G and Coppa G. Determination of plasma metformin by a new cation-exchange HPLC technique. Therapeutic Drug Monitoring 1999; 21: 330.
3. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New England Journal of Medicine 2002; 346: 393.
4. Garrett ER, Tsau J and Hinderling PH. Application of ion-pair methods to drug extraction from biological fluids: 2. Quantitative determination of biguanides in biological fluids and comparison of protein binding estimates. Journal of Pharmaceutical Sciences 1972; 61: 1411.
5. Huupponen R, Ojala-Karlsson P, Rouru J and Koulu M. Determination of metformin in plasma by high-performance liquid chromatography. Journal of Chromatography 1992; 583: 270.
6. Keal J and Somogyi A. Rapid and sensitive high-performance liquid chromatographic assay for metformin in plasma and urine using ion-pair extraction techniques. Journal of Chromatography 1986; 378: 503.
7. Kobayashi Y, Kubo H, Kinoshita T and Nishikawa T. Fluorometric determination of biguanides in serum by high-performance liquid chromatography with reagent-containing mobile phase. Journal of Chromatography 1988; 430: 65.
8. Matin SB, Karam JH and Forsham PH. Simple electron capture gas chromatographic method of the determination of oral hypoglycemic biguanides in biological fluids. Analytical Chemistry 1975; 47: 545.
9. Ross MSF. Determination of metformin in biological fluids by derivatization followed by high-performance liquid chromatography. Journal of Chromatography 1977; 133: 408.
10. Salpeter SR, Greyber E, Pasternak GA and Salpeter EE. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Archives of Internal Medicine 2003; 163: 2594.
11. Scheen JA. Clinical pharmacokinetics of metformin. Clinical Pharmacokinetics 1996; 30: 359.
12. Stang M, Wysowsky DK and Butler-Jones D. Incidence of lactic acidosis in metformin users. Diabetes Care 1999; 22: 925.
13. Wang Y, Tan Y, Gu J, Fawcett JP and Bai X. Rapid and sensitive liquid chromatography-tandem mass spectrometric method for the quantitation of metformin in human plasma. Journal of Chromatography B 2004; 808: 215.
14. Yamamoto T, Kusama M, Matsuno K, Sugiyama E, Yamada Y and Iga T. A new method for determination of buformin in plasma and urine by ion-pair reversed-phase HPLC with ultraviolet detection. Biomedical Chromatography 2002; 16: 453.
15. Zhang M, Moore GA, Lever M, Gardiner SJ, Kirkpatrick CMJ and Begg EJ. Rapid and simple high-performance liquid chromatographic assay for the determination of metformin in human plasma and breast milk. Journal of Chromatography B 2002; 766: 175.