Community-based screening for hepatocellular carcinoma in elderly residents in a hepatitis B- and C-endemic area

Journal of Gastroenterology and Hepatology (Australia)

Volumn 26, Issue 1, 2011, Pages 129-134

  Huang, Yen Chieh ^a,c   Huang, Chih Fang ^a,d   Chang, Kuo Chin ^a,e   Hung, Shu Fen ^a   Wang, Jing Houng ^a,e   Hung, Chao Hung ^a,e   Chen, Chien Hung ^a,e   Tseng, Po Lin ^a,e   Kee, Kwong Ming ^a,e   Yen, Yi Hao ^a,e   Tsai, Pei Shan ^b   Tsai, Chin Chen ^b   Lu, Sheng Nan ^a,e  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b Health Center of Zihguan Township   (Taiwan)

^c TIAN SHENG MEMORIAL HOSPITAL   (Taiwan)

^d NANHUA UNIVERSITY   (Taiwan)

^e CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Community screening; Hepatitis C virus; Hepatocellular carcinoma; Platelet count; fetoprotein

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA FETOPROTEIN; ASPARTATE AMINOTRANSFERASE; HEPATITIS B SURFACE ANTIGEN;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CANCER REGISTRY; CANCER SCREENING; CANCER SIZE; COMMUNITY ASSESSMENT; ECHOGRAPHY; FEMALE; HEPATITIS B; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL RATE; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

EID: 78650381224     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2010.06476.x     Document Type: Article

References (30)

1. El-Serag HB. Hepatocellular carcinoma: an epidemiologic view. J Clin. Gastroenterol. 2002; 35: S72-8.
2. Collier J, Sherman M. Screening for hepatocellular carcinoma. Hepatology 1998; 27: 273-8.
3. El-Serag HB. Epidemiology of hepatocellular carcinoma. Clin. Liver Dis. 2001; 5: 87-107.
4. Department of Health, Taiwan. 2008 statistics of causes of death. Citecd 25 Jul 2010. Available from URL:
5. Okita K. Clinical aspects of hepatocellular carcinoma in Japan. Intern. Med. 2006; 45: 229-33.
6. Piantino P, Arrigoni A, Brunetto MR, Gindro T. Alpha-fetoprotein in hepatic pathology and hepatocarcinoma. J. Nucl. Med. Allied. Sci. 1989; 33: 34-8.
7. Daniele B, Bencivenga A, Megna AS, Tinessa V. Alpha-fetoprotein and ultrasonography screening for hepatocellular carcinoma. Gastroenterology 2004; 127: S108-12.
8. Chen THH, Chen CJ, Yen MF et al. Ultrasound screening and risk factors for death from hepatocellular carcinoma in a high-risk group in Taiwan. Int. J. Cancer 2002; 98: 257-61.
9. Lu SN, Wang JH, Liu SL et al. Thrombocytopenia as a surrogate for cirrhosis and a marker for the identification of patients at high-risk for hepatocellular carcinoma. Cancer 2006; 107: 2212-22.
10. Zhang BH, Yang BH, Tang ZY. Randomized controlled trial of screening for hepatocellular carcinoma. J. Cancer Res. Clin. Oncol. 2004; 130: 417-22.
11. Lu SN, Wang JH, Chen PF et al. Community-based mass ultrasonographic screening of hepatocellular carcinoma among thrombocytopenic adults. Cancer Epidemiol. Biomarkers Prev. 2008; 17: 1813-21.
12. Gannon CJ, Izzo F, Aloia TA et al. Can hepatocellular cancer screening increase the proportion of long-term survivors? Hepatogastroenterology 2009; 56: 1152-6.
13. Yuen MF, Lai CL. Screening for hepatocellular carcinoma: survival benefit and cost-effectiveness. Ann. Oncol. 2003; 14: 1463-7.
14. Yoshizawa H. Hepatocellular carcinoma associated with hepatitis C virus infection in Japan: projection to other countries in the foreseeable future. Oncology 2002; 62: 8-17.
15. Lu SN, Su WW, Yang SS et al. Secular trends and geographic variations of hepatitis B virus and hepatitis C virus-associated hepatocellular carcinoma in Taiwan. Int. J. Cancer 2006; 119: 1946-52.
16. Yuen MF, Hou JL, Chutaputti A. Hepatocellular carcinoma in the Asia Pacific region. J. Gastroenterol. Hepatol. 2009; 24: 346-53.
17. Dohmen K, Shirahama M, Shigematsu H, Irie K, Ishibashi H. Optimal treatment strategy for elderly patients with hepatocellular carcinoma. J. Gastroenterol. Hepatol. 2004; 19: 859-65.
18. Pignata S, Gallo C, Daniele B et al. CLIP Investigators. Characteristics at presentation and outcome of hepatocellular carcinoma (HCC) in the elderly. A study of the Cancer of the Liver Italian Program (CLIP). Crit. Rev. Oncol. Hematol. 2006; 59: 243-9.
19. Wu CC, Chen JT, Ho WL et al. Liver resection for hepatocellular carcinoma in octogenarians. Surgery 1999; 125: 332-8.
20. Lu SN, Chen TM, Lee CM, Wang JH, Tung HD, Wu JC. Molecular epidemiological and clinical aspects of hepatitis D virus in a unique triple hepatitis virus (B, C, D)-endemic community in Taiwan. J. Med. Virol. 2003; 70: 74-80.
21. Chen IL, Lu SN, Wu CL. HBsAg and anti-HCV prevalence among villages in an endemic township: a community study in Tzukuan, Kaohsiung. Chin. J. Public Health (Taipei) 1999; 18: 313-8.
22. Chen CH, Yang PM, Huang GT, Lee HS, Sung JL, Sheu JC. Estimation of seroprevalence of hepatitis B virus and hepatitis C virus in Taiwan from a large-scale survey of free hepatitis screening participants. J. Formos. Med. Assoc. 2007; 106: 148-55.
23. Hung CH, Lu SN, Wang JH et al. Correlation between ultrasonographic and pathologic diagnoses of hepatitis B and C virus-related cirrhosis. J. Gastroenterol. 2003; 38: 153-7.
24. Bruix J, Sherman M, Llovet JM et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona 2000 EASL conference. European Association for the Study of the Liver. J. Hepatol. 2001; 35: 421-30.
25. Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology 2005; 42: 1208-36.
26. Barletta E, Tinessa V, Daniele B. Screening of hepatocellular carcinoma: role of the alpha-fetoprotein (AFP) and ultrasonography. Recenti Prog. Med. 2005; 96: 295-9.
27. Wang CS, Yao WJ, Chang TT, Wang ST, Chou P. The impact of type 2 diabetes on the development of hepatocellular carcinoma in different viral hepatitis statuses. Cancer Epidemiol. Biomarkers Prev. 2009; 18: 2054-60.
28. El-Serag HB, Siegel AB, Davila JA et al. Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: a population-based study. J. Hepatol. 2006; 44: 158-66.
29. Department of Health, Executive Yuan, Taiwan. 2003 population and family in Taiwan. Cited 25 Jul 2010. Available from URL:
30. The Japan Society of Hepatology. Surveillance algorithm and diagnostic algorithm for hepatocellular carcinoma. Hepatol. Res. 2010; 40: 6-7.