Optimal treatment strategy for elderly patients with hepatocellular carcinoma

Journal of Gastroenterology and Hepatology (Australia)

Volumn 19, Issue 8, 2004, Pages 859-865

  Dohmen, Kazufumi ^a   Shirahama, Masafumi ^b   Shigematsu, Hirohisa ^b   Irie, Koji ^b   Ishibashi, Hiromi ^c  

^a Okabe Hospital   (Japan)

^b Saga Prefectural Hospital   (Japan)

^c NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

Author keywords

Elderly; Hepatocellular carcinoma; Prognosis; Survival rate; Therapy

Indexed keywords

ACETIC ACID; ALCOHOL; ALPHA FETOPROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER GRADING; CANCER STAGING; CAUSE OF DEATH; CHEMOEMBOLIZATION; CHEMOTHERAPY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PORTAL VEIN THROMBOSIS; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SEX DIFFERENCE; SURVIVAL RATE; TUMOR VOLUME;

EID: 4143094695     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2003.03306.x     Document Type: Article

References (29)

1. El-Serag HB, Davila JA, Petersen NJ, McGlynn KA. The continuing increase in the incidence of hepatocellular carcinoma in the United States: An update. Ann. Intern. Med. 2003; 139: 817-23.
2. Dohmen K, Shigematsu H, Irie K, Ishibashi H. Trends in clinical characteristics, treatment and prognosis of hepatocellular carcinoma. Hepatogastroenterology 2003; 50: 1872-7.
3. Yanaga K, Kanematsu T, Takenaka K, Matsumata T, Yoshida Y, Sugimachi K. Hepatic resection for hepatocellular carcinoma in elderly patients. Am. J. Surg. 1988; 155: 238-41.
4. Nomura F, Ohnishi K, Honda M, Satomura Y, Nakai T, Okuda K. Clinical features of hepatocellular carcinoma in the elderly: a study of 91 patients older than 70 years. Br. J. Cancer 1994; 70: 690-3.
5. Poon RTP, Fan S-T, Lo C-M et al. Hepatocellular carcinoma in the elderly: results of surgical and nonsurgical management. Am. J. Gastroenterol. 1999; 94: 2460-6.
6. Hazama H, Omagari K, Matsuo I et al. Clinical features and treatment of hepatocellular carcinoma in eight patients older than eighty years of age. Hepatogastroenterofogy 2001; 48: 1692-6.
7. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48 900 necropsies. Cancer 1954; 7: 462-503.
8. Kaplan EL, Meier P. Nonparametric estimation for incomplete observations. J. Am. Stat. Assoc. 1958; 53: 457-81.
9. Hoshida Y, Ikeda K, Kobayashi M et al. Chronic liver disease in the extremely elderly of 80 years or more: clinical characteristics, prognosis and patient survival analysis. J. Hepatol. 1999; 31: 860-6.
10. Arbaje YM, Carbone PP. Hepatocellular carcinoma in very elderly: to treat or not to treat? Med. Pediatr. Oncol. 1994; 22: 84-7.
11. Collier JD, Curless R, Bassendine MF, James OFW. Clinical features and prognosis of hepatocellular carcinoma in Britain in relation to age. Age Ageing 1994; 23: 22-7.
12. Namieno T, Kawata A, Sato N, Kondo Y, Uchino J. Age-related, different clinocopathologic features of hepatocellular carcinoma patients. Ann. Surg. 1995; 221: 308-14.
13. Hoshida Y, Ikeda K, Saitoh S et al. The efficacy and prognosis of transcatheter chemoembolization for hepatocellular carcinoma in the elderly. Jpn. J. Gastroenterol. 1999; 96: 142-6 (in Japanese with English abstract).
14. Ministry of Health and Welfare. Complete Life Tables for Japan. Tokyo: Ministry of Health and Welfare, 2000.
15. Yamaoka Y, Liver Cancer Study Group of Japan. Survey and follow-up study of primary liver cancer in Japan-report 15, 1998-1999. In: Yamaoka Y, ed. Kyoto: Shinkoinsatsu Publisher, 2002; 1-117.
16. Dohmen K, Shirahama M, Miyamoto Y, Torii Y, Irie K, Ishibashi H. Differences in survival based on the type of follow-up for the detection of hepatocellular carcinoma: an analysis of 547 patients. Hepatol. Res. 2000; 18: 110-21.
17. Okuda K. Hepatocellular carcinoma. J. Hepatol. 2000; 32 (Suppl. 1): 225-37.
18. Kato Y, Nakata K, Omagari K et al. Risk of hepatocellular carcinoma in patients with cirrhosis in Japan. Analysis of infectious hepatitis viruses. Cancer 1994; 74: 2234-8.
19. Dohmen K, Shigematsu H, Irie K, Ishibashi H. Comparison of the clinical characteristics among hepatocellular carcinoma of hepatitis B, hepatitis C and non-B non-C patients. Hepatogastroenterology 2003; 50: 2022-7.
20. Yamamoto K, Takenaka K, Matsumata T et al. Right hepatic lobectomy in elderly patients with hepatocellular carcinoma. Hepatogastroenterology 1997; 44: 514-18.
21. Lencioni R, Bartolozzi C, Caramella D et al. Treatment of small hepatocellular carcinoma with percutaneous ethanol injection. Analysis of prognostic factors in 105 Western patients. Cancer 1995; 76: 1737-46.
22. Dohmen K, Shirahama M, Shigematsu H et al. Transcatheter arterial chemoembolization therapy combined with percutaneous ethanol injection for unresectable large hepatocellular carcinoma: An evaluation of the local therapeutic effect and survival rate. Hepatogastroenterology 2001; 48: 1409-15.
23. Fong Y, Blumgart LH, Former JG, Brennan MF. Pancreatic or liver resection for malignancy is safe and effective for the elderly. Ann. Surg. 1995; 222: 426-37.
24. Karl RC, Smith SK, Fabri PJ. Validity of major cancer operations in elderly patients. Ann. Surg. Oncol. 1995; 2: 107-13.
25. Chlebowski RT, Tong M, Weissman J et al. Hepatocellular carcinoma: diagnostic and prognostic features in North American patients. Cancer 1984; 53: 2701-6.
26. Falkson G, Cnaan A, Schutt AJ, Ryan LM, Falkson HC. Prognostic factors of hepatocellular carcinoma. Cancer Res. 1988; 48: 7314-18.
27. Calvet X, Bruix J, Gines P et al. Prognostic factors of hepatocellular carcinoma in the West: a multivariate analysis in 206 patients. Hepatology 1990; 12: 753-60.
28. Okada S, Okazaki N, Nose H, Yoshimori M, Aoki K. Prognostic factors in patients with hepatocellular carcinoma receiving systemic chemotherapy. Hepatology 1992; 16: 112-17.
29. Okuda K. Early recognition of hepatocellular carcinoma. Hepatology 1986; 6: 729-38.