Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection

European Journal of Immunology

Volumn 41, Issue 1, 2011, Pages 76-88

  Porubsky, Stefan ^a,d   Wang, Shijun ^a   Kiss, Eva ^a   Dehmel, Stefan ^b   Bonrouhi, Mahnaz ^a   Dorn, Tatjana ^c   Luckow, Bruno ^b   Brakebusch, Cord ^c   Gröne, Hermann Josef ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Animal models; T cell; Transplantation

Indexed keywords

ALLOANTIBODY; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOH; UNCLASSIFIED DRUG;

ALLOIMMUNITY; ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME DEFICIENCY; GRAFT REJECTION; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; KIDNEY TRANSPLANTATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ACUTE DISEASE; ANIMALS; ANTIBODIES; ANTIGEN PRESENTATION; CHRONIC DISEASE; CYTOKINES; DENDRITIC CELLS; GRAFT REJECTION; ISOANTIGENS; KIDNEY TRANSPLANTATION; LYMPHOCYTE CULTURE TEST, MIXED; MALE; MICE; MICE, INBRED BALB C; MICE, MUTANT STRAINS; MICE, SCID; RHO GTP-BINDING PROTEINS; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 78650370596     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040420     Document Type: Article

References (30)

1. Etienne-Manneville, S. and Hall, A., Rho GTPases in cell biology. Nature 2002. 420: 629-635.
2. Dallery, E., Galiegue-Zouitina, S., Collyn-d'Hooghe, M., Quief, S., Denis, C., Hildebrand, M. P., Lantoine, D. et al., TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation. Oncogene 1995. 10: 2171-2178.
3. Pasqualucci, L., Neumeister, P., Goossens, T., Nanjangud, G., Chaganti, R. S., Kuppers, R. and Dalla-Favera, R., Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature 2001. 412: 341-346.
4. Preudhomme, C., Roumier, C., Hildebrand, M. P., Dallery-Prudhomme, E., Lantoine, D., Lai, J. L., Daudignon, A. et al., Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma. Oncogene 2000. 19: 2023-2032.
5. Gu, Y., Jasti, A. C., Jansen, M. and Siefring, J. E., RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells. Blood 2005. 105: 1467-1475.
6. Li, X., Bu, X., Lu, B., Avraham, H., Flavell, R. A. and Lim, B., The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol. Cell Biol. 2002. 22: 1158-1171.
7. Schmidt-Mende, J., Geering, B., Yousefi, S. and Simon, H. U., Lysosomal degradation of RhoH protein upon antigen receptor activation in T but not B cells. Eur. J. Immunol. 2009. 40: 525-529.
8. Dorn, T., Kuhn, U., Bungartz, G., Stiller, S., Bauer, M., Ellwart, J., Peters, T. et al., RhoH is important for positive thymocyte selection and T-cell receptor signaling. Blood 2007. 109: 2346-2355.
9. Gu, Y., Chae, H. D., Siefring, J. E., Jasti, A. C., Hildeman, D. A. and Williams, D. A., RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development. Nat. Immunol. 2006. 7: 1182-1190.
10. Oda, H., Fujimoto, M., Patrick, M. S., Chida, D., Sato, Y., Azuma, Y., Aoki, H. et al., RhoH plays critical roles in FcepsilonRI-dependent signal transduction in mast cells. J. Immunol. 2009. 182: 957-962.
11. Dehmel, S., Wang, S., Schmidt, C., Kiss, E., Loewe, R. P., Chilla, S., Schlondorff, D. et al., Chemokine receptor Ccr5-deficiency induces alternative macrophage activation and improves long-term renal allograft outcome. Eur. J. Immunol. 2010. 40: 267-278.
12. Wang, S., Schmaderer, C., Kiss, E., Schmidt, C., Bonrouhi, M., Porubsky, S., Gretz, N. et al., Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling. Dis. Model Mech. 2010. 3: 92-103.
13. Bosma, M. J. and Carroll, A. M., The SCID mouse mutant: definition, characterization, and potential uses. Annu. Rev. Immunol. 1991. 9: 323-350.
14. Cherry, L. K., Li, X., Schwab, P., Lim, B. and Klickstein, L. B., RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes. Nat. Immunol. 2004. 5: 961-967.
15. Daryadel, A., Yousefi, S., Troi, D., Schmid, I., Schmidt-Mende, J., Mordasini, C., Dahinden, C. A. et al., RhoH/TTF negatively regulates leukotriene production in neutrophils. J. Immunol. 2009. 182: 6527-6532.
16. Mack, M. and Rosenkranz, A. R., Basophils and mast cells in renal injury. Kidney Int. 2009. 76: 1142-1147.
17. Mengel, M., Reeve, J., Bunnag, S., Einecke, G., Sis, B., Mueller, T., Kaplan, B. and Halloran, P. F., Molecular correlates of scarring in kidney transplants: the emergence of mast cell transcripts. Am. J. Transplant. 2009. 9: 169-178.
18. Matsumoto, M., Oyamada, K., Takahashi, H., Sato, T., Hatakeyama, S. and Nakayama, K. I., Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways. Proteomics 2009. 9: 3549-3563.
19. Sanchez-Aguilera, A., Rattmann, I., Drew, D. Z., Muller, L. U., Summey, V., Lucas, D. M., Byrd, J. C. et al., Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia. Leukemia 2010. 24: 97-104.
20. Bosma, G. C., Custer, R. P. and Bosma, M. J., A severe combined immunodeficiency mutation in the mouse. Nature 1983. 301: 527-530.
21. Zhang, Z., Schlachta, C., Duff, J., Stiller, C., Grant, D. and Zhong, R., Improved techniques for kidney transplantation in mice. Microsurgery 1995. 16: 103-109.
22. Adams, J., Kiss, E., Arroyo, A. B., Bonrouhi, M., Sun, Q., Li, Z., Gretz, N. et al., 13-cis retinoic acid inhibits development and progression of chronic allograft nephropathy. Am. J. Pathol. 2005. 167: 285-298.
23. Grone, H. J., Cohen, C. D., Grone, E., Schmidt, C., Kretzler, M., Schlondorff, D. and Nelson, P. J., Spatial and temporally restricted expression of chemokines and chemokine receptors in the developing human kidney. J. Am. Soc. Nephrol. 2002. 13: 957-967.
24. Neusser, M. A., Lindenmeyer, M. T., Moll, A. G., Segerer, S., Edenhofer, I., Sen, K., Stiehl, D. P. et al., Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Am. J. Pathol. 2010. 176: 594-607.
25. Amano, H., Bickerstaff, A., Orosz, C. G., Novick, A. C., Toma, H. and Fairchild, R. L., Absence of recipient CCR5 promotes early and increased allospecific antibody responses to cardiac allografts. J. Immunol. 2005. 174: 6499-6508.
26. Hopken, U. E., Droese, J., Li, J. P., Joergensen, J., Breitfeld, D., Zerwes, H. G. and Lipp, M., The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses. Eur. J. Immunol. 2004. 34: 461-470.
27. Lutz, M. B., Kukutsch, N., Ogilvie, A. L., Rossner, S., Koch, F., Romani, N. and Schuler, G., An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 1999. 223: 77-92.
28. Karttunen, J., Sanderson, S. and Shastri, N., Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens. Proc. Natl. Acad. Sci USA 1992. 89: 6020-6024.
29. Shimonkevitz, R., Kappler, J., Marrack, P. and Grey, H., Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J. Exp. Med. 1983. 158: 303-316.
30. Kruisbeek, A. M., Shevach, E. and Thornton, A. M., Proliferative assays for T cell function. Curr. Protoc. Immunol. 2004. Chapter 3: Unit 3 12.