Diagnostic utility of α-methylacyl CoA racemase (P504S) & HMWCK in morphologically difficult prostate cancer

Diagnostic Pathology

Volumn 5, Issue 1, 2010, Pages

  Kumaresan, K ^a   Kakkar, Nandita ^a   Verma, Alka ^a   Mandal, Arup K ^a   Singh, Shrawan K ^a   Joshi, Kusum ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE; ALPHA-METHYLACYL-COA RACEMASE; ISOMERASE; KERATIN; TUMOR MARKER;

AGED; ARTICLE; BIOPSY; CARCINOMA; CASE CONTROL STUDY; ENZYMOLOGY; EVALUATION; HUMAN; IMMUNOHISTOCHEMISTRY; INDIA; MALE; MIDDLE AGED; MOLECULAR WEIGHT; PATHOLOGY; PREDICTIVE VALUE; PROSTATE TUMOR; PROSTATECTOMY; SENSITIVITY AND SPECIFICITY;

AGED; AGED, 80 AND OVER; BIOPSY; CARCINOMA; CASE-CONTROL STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; INDIA; KERATINS; MALE; MIDDLE AGED; MOLECULAR WEIGHT; PREDICTIVE VALUE OF TESTS; PROSTATECTOMY; PROSTATIC NEOPLASMS; RACEMASES AND EPIMERASES; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 78650336166     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-5-83     Document Type: Article

References (35)

1. Epstein JI, Yang XJ. Prostate biopsy interpretation.3rd ed. Philadelphia, PA:Lippincott Williams & Wilkins. 2002,
2. Srigley JR. Benign mimickers of prostatic adenocarcinoma. Mod Pathol 2004, 17:328-348. 10.1038/modpathol.3800055, 14976539.
3. Helpap B. Differential diagnosis of glandular proliferations in the prostate:a conventional and immunohistochemical approach. Virchows Arch 1998, 433:397-405. 10.1007/s004280050266, 9849853.
4. Hoedemaeker RF, Van der Kwast TH, Schroder FH. The clinical significance of a small focus of well differentiated carcinoma at prostate biopsy. BJU Int 2003, 92(Suppl 2):92-96. 10.1111/j.1465-5101.2003.04406.x, 14983963.
5. Wojno KJ, Epstein JI. The utility of basal cell-specific anti-cytokeratin antibody (34 beta E12) in the diagnosis of prostate cancer. A review of 228 cases. Am J Surg Pathol 1995, 19(3):251-260. 10.1097/00000478-199503000-00002, 7532918.
6. Kahane H, Sharp JW, Shuman GB, Dasilva G, Epstein JI. Utilization of high molecular weight cytokeratin on prostate needle biopsies in an independent laboratory. Urology 1995, 45(6):981-986. 10.1016/S0090-4295(99)80118-6, 7539563.
7. Shah RB, Zhou M, LeBlanc M, Snyder M, Rubin MA. Comparison of the basal cell-specific markers, 34betaE12 and p63, in the diagnosis of prostate cancer. Am J Surg Pathol 2002, 26(9):1161-1168. 10.1097/00000478-200209000-00006, 12218572.
8. Varma M, Jasani B. Diagnostic utility of immunohistochemistry in morphologically difficult prostate cancer: review of current literature. Histopathology 2005, 47(1):1-16. 10.1111/j.1365-2559.2005.02188.x, 15982318.
9. Jiang Z, Wu CL, Woda BA, Iczkowski KA, Chu PG, Tretiakova MS, et al. Alpha-methylacyl-CoA racemase: a multi-institutional study of a new prostate cancer marker. Histopathology 2004, 45(3):218-225. 10.1111/j.1365-2559.2004.01930.x, 15330799.
10. Chan TY, Epstein JI. Follow-up of atypical prostate needle biopsies suspicious for cancer. Urology 1999, 53(2):351-355. 10.1016/S0090-4295(98)00510-X, 9933053.
11. Allen EA, Kahane H, Epstein JI. Repeat biopsy strategies for men with atypical diagnoses on initial prostate needle biopsy. Urology 1998, 52(5):803-807. 10.1016/S0090-4295(98)00291-X, 9801103.
12. Oppenheimer JR, Wills ML, Epstein JI. Partial atrophy in prostate needle cores:another diagnostic pitfall for the surgical pathologist. Am J Surg Pathol 1998, 22:440-445. 10.1097/00000478-199804000-00008, 9537471.
13. Bostwick DG, Srigley J, Grignon D, Maksem J, Humphrey P, van der Kwast TH, et al. Atypical adenomatous hyperplasia of the prostate: morphologic criteria for its distinction from well-differentiated carcinoma. Hum Pathol 1993, 24(8):819-832. 10.1016/0046-8177(93)90131-Y, 8375853.
14. Yang XJ, Lecksell K, Gaudin P, Epstein JI. Rare expression of high molecular-weight cytokeratin in adenocarcinoma of the prostate gland: a study of 100 cases of metastatic and locally advanced prostate cancer. Am J Surg Pathol 1999, 23:147-152. 10.1097/00000478-199902000-00002, 9989840.
15. Gaudin PB, Epstein JI. Adenosis of the prostate. Histologic features in needle biopsy specimens. Am J Surg Pathol 1995, 19(7):737-747. 10.1097/00000478-199507000-00001, 7793471.
16. Amin MB, Tamboli P, Varma M, Srigley JR. Postatrophic hyperplasia of the prostate gland: a detailed analysis of its morphology in needle biopsy specimens. Am J Surg Pathol 1999, 23(8):925-931. 10.1097/00000478-199908000-00010, 10435562.
17. Skinnider BF, Olivia E, Young RH eta L. Expression of racemase in nephrogenic adenoma: a significant immunohistochemical pitfall compounding the differential diagnosis with prostatic adenocarcinoma. Am J Surg Pathol 2004, 28:701-705. 10.1097/01.pas.0000126759.43227.d9, 15166661.
18. Cina SJ, Silberman MA, Kahane H et A. Diagnosis of Cowper's glands on prostate needle biopsy. Am J Surg Pathol 1997, 21:550-555. Saboorian M H, Huffman H, Ashfaq R eta l:Distinguishing Cowper's glands from neoplastic and pseudoneoplastic lesions of the prostate: immunohistochemical and ultrastructural study. Am J Surg Pathol 1997;21:1069-1074, 10.1097/00000478-199705000-00007, 9158679.
19. Oliai BR, Kahane H, Epstein JI. Can basal cells be seen in adenocarcinoma of the prostate? An immunohistochemical study using HMWCK (34βE12) antibody. AM J Surg Pathol 2002, 26:1151-1160. 10.1097/00000478-200209000-00005, 12218571.
20. Jiang Z, Woda BA, Rock KL, Xu Y, Savas L, Khan A, et al. P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol 2001, 25(11):1397-1404. 10.1097/00000478-200111000-00007, 11684956.
21. Luo J, Zha S, Gage WR, Dunn TA, Hicks JL, Bennett CJ, et al. Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer. Cancer Res 2002, 62(8):2220-2226.
22. Zhou M, Aydin H, Kanane H, Epstein JI. How often does alph-methylacyl-CoA-recemase contribute to resolving an atypical diagnosis on prostate needle biopsy beyond that provided by basal cell marker?. Am J Surg Pathol 2004, 28:239-243. 10.1097/00000478-200402000-00012, 15043314.
23. Kunju LP, Rubin MA, Chinnaiyan AM, Shah RB. Diagnostic usefulness of monoclonal antibody P504 S in the workup of atypical prostatic glandular proliferations. Am J Clin Pathol 2003, 120(5):737-745. 10.1309/3T3Y0K0TUMYH3WY2, 14608901.
24. Jiang Z, wU CL, Woda BA, et al. P504S/alpha-methyl-CoA racemase: a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy. Am J Surg Pathol 2002, 26:1169-1174. 10.1097/00000478-200209000-00007, 12218573.
25. Yang XJ, Wu CL, Woda BA, Dresser K, Tretiakova M, Fanger GR, et al. Expression of alpha-Methylacyl-CoA racemase (P504S) in atypical adenomatous hyperplasia of the prostate. Am J Surg Pathol 2002, 26(7):921-925. 10.1097/00000478-200207000-00011, 12131160.
26. Gupta A, Wang HL, Policarpio-Nicolas ML, Tretiakova MS, Papavero V, Pins MR, et al. Expression of alpha-methylacyl-coenzyme A racemase in nephrogenic adenoma. Am J Surg Pathol 2004, 28(9):1224-1229. 10.1097/01.pas.0000131544.18266.a4, 15316323.
27. Allan CH, Epstein JI. Nephrogenic adenoma of the prostatic urethra: a mimicker of prostate adenocarcinoma. Am J Surg Pathol 2001, 25(6):802-808. 10.1097/00000478-200106000-00013, 11395559.
28. Jonathan I, Epstein, Herawi M, et al. Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: Implications for patient care. Journal of Urol 2006, 175:820-834.
29. Jiang Z, Iczkowski KA, Woda BA, Tretiakova M, Yang XJ. P504 S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. Am J Clin Pathol 2004, 121(1):99-107. 10.1309/7T7RJCCL84JGXH3L, 14750247.
30. Browne TJ, Hirsch MS, Brodsky G, Welch WR, Loda MF, Rubin MA. Prospective evaluation of AMACR (P504S) and basal cell markers in the assessment of routine prostate needle biopsy specimens. Hum Pathol 2004, 35(12):1462-1468. 10.1016/j.humpath.2004.09.009, 15619204.
31. Sanderson SO, Sebo TJ, Murphy LM, et al. An analysis of the p63/alphamethylacyl coenzyme A racemase immunohistochemical cocktail stain in prostate needle biopsy specimens and tissue microarrays. Am J Clin Pathol 2004, 121:220-225. 10.1309/JBCUTWDPD7EMAKLP, 14983935.
32. Molinie V, Fromont G, Sibony M, et al. Diagnostic utility of a p63 / alpha-methyl-CoA-racemase (p504s) cocktail in atypical foci in the prostate. Mod Pathol 2004, 17. 10.1038/modpathol.3800197, 15205683.
33. Jiang Z, Wu CL, Woda BA, et al. P504S/alpha-methyl-CoA Racemase: a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy. Am J Surg Pathol 2002, 26:1169-1174. 10.1097/00000478-200209000-00007, 12218573.
34. Magi Galluzzi C, Luo J, Isaacs WB, Hicks JI, de Marzo AM, Epstein JI. Alpha-methyl-CoA Racemase: a variably sensitive immunohistochemical marker fro the diagnosis of small prostatic cancer foci on needle biopsy. Am J Surg Pathol 2003, 27:1128-1133. 10.1097/00000478-200308000-00010, 12883245.
35. Varma M, Linden MD, Amin MB. Effect of formalin fixation and epitope retrieval techniques on antibody 34betaE12 immunostaining of prostatic tissues. Mod Pathol 1999, 12(5):472-478.