How Often Does Alpha-Methylacyl-CoA-Racemase Contribute to Resolving an Atypical Diagnosis on Prostate Needle Biopsy Beyond That Provided by Basal Cell Markers?

American Journal of Surgical Pathology

Volumn 28, Issue 2, 2004, Pages 239-243

  Zhou, Ming ^a   Aydin, Hakan ^a   Kanane, Hillel ^b   Epstein, Jonathan I ^a,c  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b Dianon Systems   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Alpha methylacyl CoA racemase; Prostate cancer

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE; CELL MARKER; CYTOKERATIN; EOSIN; HEMATOXYLIN; PROTEIN P63; RACEMASE; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; BASAL CELL; BENIGN TUMOR; CANCER DIAGNOSIS; CYTOLOGY; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MEDICAL EXPERT; NEEDLE BIOPSY; PROSTATE BIOPSY; PROSTATE CANCER; PROTEIN EXPRESSION;

BIOLOGICAL MARKERS; BIOPSY, NEEDLE; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PROSTATE; PROSTATIC NEOPLASMS; RACEMASES AND EPIMERASES; STAINING AND LABELING; TUMOR MARKERS, BIOLOGICAL;

EID: 1642453627     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200402000-00012     Document Type: Article

References (10)

1. Beach R, Gown AM, de Peralta-Venturina MN, et al. P504S immunohistochemical detection in 405 prostatic specimens including 376 18-guage needle biopsics. Am J Surg Pathol. 2002;26:1588-1596
2. Chan TY, Epstein JI. Follow-up of atypical prostate needle biopsies suspicious for cancer. Urology. 1999;53:351-355.
3. Ferdinandusse S, Denis S, Ijist L, et al. Subcellular localization and physiological role of alpha-methylacyl-CoA racemase. J Lipid Res. 2000;41:1890-1896.
4. Jiang Z, Woda BA, Rock KL, et al. P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol. 2001;25:1397-1404.
5. Magi-Galluzzi C, Luo J, Isaacs WB, et al. Alpha-methylacyl-CoA racemase: a variably sensitive immunohistochemical marker for the diagnosis of small prostate cancer foci on needle biopsy. Am J Surg Pathol. 2003;27:1128-1133.
6. Luo J, Zha S, Gage WR, et al. Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer. Cancer Res. 2002;62:2220-2226.
7. Rubin MA, Zhous M, Dhanasekaran SM, et al. alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer. JAMA. 2002;287:1662-1670.
8. Yang XJ, Wu CL, Woda BA, et al. Expression of alpha-methylacyl-CoA racemase (P504S) in atypical adenomatous hyperplasia of the prostate. Am J Surg Pathol. 2002;26:921-925.
9. Zhou M, Chinnaiyan AM, Kleer CG, et al. Alpha-mcehylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions. Am J Surg Pathol. 2002;26:926-931.
10. Zhou M, Jiang Z, Epstein JI. Expression and diagnostic utility of alpha-methyacyl-CoA-racemase (P504S) in foamy gland and pseudohyperplastic prostate cancer. Am J Surg Pathol. 2003;27:772-778.