An electrochemical microfluidic platform for human P450 drug metabolism profiling

Analytical Chemistry

Volumn 82, Issue 24, 2010, Pages 10222-10227

  Fantuzzi, Andrea ^a   Capria, Ennio ^a   Mak, Lok Hang ^a   Dodhia, Vikash R ^a   Sadeghi, Sheila J ^b   Collins, Stephen ^c   Somers, Graham ^d   Huq, Ejaz ^e   Gilardi, Gianfranco ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF TURIN   (Italy)

^c NanoBioDesign Ltd   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

^e RUTHERFORD APPLETON LABORATORY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7-MERCAPTOHEPTANOIC ACIDS; COVALENTLY BOUND; DRUG METABOLISMS; ELECTROCHEMICAL MEASUREMENTS; ELECTROCHEMICAL RESPONSE; HUMAN CYTOCHROME; HUMAN LIVER MICROSOMES; MICROFLUIDIC CELL; MICROFLUIDIC PLATFORMS; NEW CHEMICAL ENTITIES; NIFEDIPINE; REACTION CHAMBERS;

CARBOXYLIC ACIDS; DRUG INTERACTIONS; ESTERS; MICROFLUIDICS; PYRIDINE; SELF ASSEMBLED MONOLAYERS; TITRATION;

ELECTROCHEMICAL ELECTRODES;

ALOSETRON; CARBOLINE DERIVATIVE; CYTOCHROME P450; NIFEDIPINE; ONDANSETRON; QUINIDINE;

ARTICLE; ELECTROCHEMICAL ANALYSIS; ELECTRODE; ENZYME SPECIFICITY; HUMAN; INSTRUMENTATION; LIVER MICROSOME; METABOLISM; METHODOLOGY; MICROFLUIDICS;

CARBOLINES; CYTOCHROME P-450 ENZYME SYSTEM; ELECTROCHEMICAL TECHNIQUES; ELECTRODES; HUMANS; MICROFLUIDICS; MICROSOMES, LIVER; NIFEDIPINE; ONDANSETRON; QUINIDINE; SUBSTRATE SPECIFICITY;

EID: 78650332432     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac102480k     Document Type: Article

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