Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2- ethanediones: Potent, selective carboxylesterase inhibitors

Journal of Medicinal Chemistry

Volumn 53, Issue 24, 2010, Pages 8709-8715

  Young, Brandon M ^a   Hyatt, Janice L ^a   Bouck, David C ^a,b   Chen, Taosheng ^a   Hanumesh, Parimala ^a   Price, Jeanine ^a   Boyd, Vincent A ^a   Potter, Philip M ^a   Webb, Thomas R ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 AMINOPHENYL) 2 (PYRIDIN 2 YL)ETHANE 1,2 DIONE; 1 PYRIDYL 2 PHENYL 1,2 ETHANEDIONE DERIVATIVE; CARBOXYLESTERASE INHIBITOR; ESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; CARBOXYLESTERASE; CHOLINESTERASE INHIBITORS; GLYOXAL; HUMANS; PYRIDINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78650315616     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101101q     Document Type: Article

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