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For the vinylic hydrogen, strong NOE was observed with 5-pyrimidinyl hydrogen and weaker effect with the 2-and 6-hydrogens of the 4-fluorophenyl. These aryl hydrogens, however, showed strong NOE with t-butyl hydrogens. See the Supporting Information for the NOE spectra.
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4-Fluorobenzoic acid was isolated and characterized.
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4 (Cairox M) purchased from Carus Chemical Co.
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