Continuous subcutaneous instillation of bupivacaine compared to saline reduces interleukin 10 and increases substance p in surgical wounds after cesarean delivery

Anesthesia and Analgesia

Volumn 111, Issue 6, 2010, Pages 1452-1459

  Carvalho, Brendan ^a   Clark, David J ^a,b   Yeomans, David C ^a   Angst, Martin S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; CHEMOKINE; CYTOKINE; FENTANYL; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IBUPROFEN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1; MORPHINE; NERVE GROWTH FACTOR; OXYCODONE; PARACETAMOL; PROSTAGLANDIN E2; SODIUM CHLORIDE; SUBSTANCE P; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANESTHESIA INDUCTION; ARTICLE; CESAREAN SECTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MEDIATOR RELEASE; NOCICEPTION; PAIN; PRIORITY JOURNAL; PROTEIN DETERMINATION; SPINAL ANESTHESIA; SUBCUTANEOUS DRUG ADMINISTRATION; SURGICAL WOUND; WOUND DRAINAGE; WOUND FLUID;

ADULT; ANALGESIA, OBSTETRICAL; ANESTHETICS, LOCAL; BUPIVACAINE; CALIFORNIA; CESAREAN SECTION; DINOPROSTONE; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXUDATES AND TRANSUDATES; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INFUSIONS, SUBCUTANEOUS; INTERLEUKIN-10; NERVE GROWTH FACTOR; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PREGNANCY; SODIUM CHLORIDE; SUBCUTANEOUS TISSUE; SUBSTANCE P; SURGICAL PROCEDURES, ELECTIVE; TIME FACTORS; TREATMENT OUTCOME; UP-REGULATION;

EID: 78650309497     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3181f579de     Document Type: Article

References (42)

1. Liu SS, Richman JM, Thirlby RC, Wu CL. Efficacy of continu-ous wound catheters delivering local anesthetic for postopera-tive analgesia: a quantitative and qualitative systematic review of randomized controlled trials. J Am Coll Surg 2006; 203:914-32
2. Givens VA, Lipscomb GH, Meyer NL. A randomized trial of postoperative wound irrigation with local anesthetic for pain after cesarean delivery. Am J Obstet Gynecol2002;186:1188-91
3. Fredman B, Shapiro A, Zohar E, Feldman E, Shorer S, RawalN, Jedeikin R. The analgesic efficacy of patient-controlled ropiva-caine instillation after cesarean delivery. Anesth Analg 2000;91:1436-40
4. Busfield BT, Romero DM. Pain pump use after shoulder arthroscopy as a cause of glenohumeral chondrolysis. Arthro-scopy 2009;25:647-52
5. Webb ST, Ghosh S. Intra-articular bupivacaine: potentially chondrotoxic? Br J Anaesth 2009;102:439-41
6. Kaba A, Laurent SR, Detroz BJ, Sessler DI, Durieux ME, Lamy ML, Joris JL. Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy. Anesthesiology 2007;106:11-8
7. Herroeder S, Pecher S, Schonherr ME, Kaulitz G, Hahnenkamp K, Friess H, Bottiger BW, Bauer H, Dh kgraaf OG, Durieux ME, Hollmann MW. Systemic lidocaine srtens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial. Ann Surg 2007;246:192-200
8. Swanton BJ, Shorten GD. Anti-inflammatory effects of local anesthetic agents. Int Anesthesiol Clin 2003;41:1-19
9. Cassuto J, Sinclair R, Bonderovic M. Anti-inflammatory prop-erties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 2006;50:265-82
10. Schmidt W, Schmidt H, Bauer H, Gebhard MM, Martin E. Influence of lidocaine on endotoxin-induced leukocyte-endothelial cell adhesion and macromolecular leakage in vivo. Anesthesiology 1997;87:617-24
11. MacGregor RR, Thorner RE, Wright DM. Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites. Blood 1980;56:203-9
12. Paul H, Clayburne G, Schumacher HR. Lidocaine inhibits leukocyte migration and phagocytosis in monosodium urate crystal-induced synovitis in dogs. J Rheumatol 1983;10:434-9
13. Sinclair R, Eriksson AS, Gretzer C, Cassuto J, Thomsen P. Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro. Acta Anaesthesiol Scand 1993;37:159-65
14. Lahav M, Levite M, Bassani L, Lang A, Fidder H, Tal R, Bar-Meir S, Mayer L, Chowers Y. Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells. Clin Exp Immunol 2002; 127:226-33
15. Eriksson AS, Sinclair R, Cassuto J, Thomsen P. Influence of lidocaine on leukocyte function in the surgical wound. Anes-thesiology 1992;77:74-8
16. Clark JD, Shi X, Li X, Qiao Y, Liang D, Angst MS, Yeomans DC Morphine reduces local cytokine expression and neutrophil infiltration after incision. Mol Pain 2007;3:28
17. Dallos A, Kiss M, Polyanka H, Dobozy A, Kemeny L, Husz S. Effects of the neuropeptides substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide and galanin on the production of nerve growth factor and inflammatory cytokines in cultured human keratinocytes. Neuropeptides 2006;40:251-63
18. Sato Y, Ohshima T, Kondo T. Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing. Biochem Biophys Res Commun 1999;265:194-9
19. Yamaguchi M, Kojima T, Kanekawa M, Aihara N, Nogimura A, Kasai K. Neuropeptides stimulate production of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in human dental pulp cells. Inflamm Res 2004;53:199-204
20. Carvalho B, Clark DJ, Angst MS. Local and systemic release of cytokines, nerve growth factor, prostaglandin E2, and sub-stance P in incisional wounds and serum following cesarean delivery. J Pain 2008;9:650-7
21. Carvalho B, Clark DJ, Yeomans D, Angst MS. Collecting and measuring nociceptive and inflammatory mediators in surgical wounds. J Vis Exp 2008;20:pii 962
22. Gordon DB, Stevenson KK, Griffie J, Muchka S, Rapp C, Ford-Roberts K. Opioid equianalgesic calculations. J Palliat Med 1999;2:209-18
23. Mosser DM, Zhang X. Interleukin-10: new perspectives on an old cytokine. Immunol Rev 2008;226:205-18
24. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Im-munol 2001;19:683-765
25. Kato M, Honda I, Suzuki H, Murakami M, Matsukawa S, Hashimoto Y. Interleukin-10 production during and after upper abdominal surgery. J Clin Anesth 1998;10:184-8
26. Huang YH, Tsai PS, Huang CJ. Bupivacaine inhibits COX-2 expression, PGE2, and cytokine production in endotoxin-activated macrophages. Acta Anaesthesiol Scand 2008; 52:530-5
27. Sun X, Wang D, Yu H, Hu L. Serial cytokine levels during wound healing in rabbit maxillary sinus mucosa. Acta Otolar-yngol 2010;130:607-13
28. Peranteau WH, Zhang L, Muvarak N, Badillo AT, Radu A, Zoltick PW, Liechty KW. IL-10 overexpression decreases in-flammatory mediators and promotes regenerative healing in an adult model of scar formation. J Invest Dermatol 2008;128:1852-60
29. Sahbaie P, Shi X, Guo TZ, Qiao Y, Yeomans DC, Kingery WS, Clark JD. Role of substance P signaling in enhanced nocicep-tive sensitization and local cytokine production after incision. Pain 2009;145:341-9
30. Birklein F, Schmelz M. Neuropeptides, neurogenic inflamma-tion and complex regional pain syndrome (CRPS). Neurosci Lett 2008;437:199-202
31. Henry JL. Substance P and inflammatory pain: potential of substance P antagonists as analgesics. Agents Actions Suppl 1993;41:75-87
32. Muangman P, Tamura RN, Muffley LA, Isik FF, Scott JR, Xie C, Kegel G, Sullivan SR, Liang Z, Gibran NS. Substance P enhances wound closure in nitric oxide synthase knockout mice. J Surg Res 2009;153:201-9
33. Rook JM, Hasan W, McCarson KE. Morphine-induced early delays in wound closure: involvement of sensory neuropep-tides and modification of neurokinin receptor expression. Biochem Pharmacol 2009;77:1747-55
34. Dias MP, Newton DJ, McLeod GA, Khan F, Belch JJ. The inhibitory effects of local anaesthetics on the vascular flare responses to bradykinin and substance P in human skin. Anaesthesia 2008;63:151-5
35. Leffler A, Fischer MJ, Rehner D, Kienel S, Kistner K, Sauer SK, Gavva NR, Reeh PW, Nau C. The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest 2008;118:763-76
36. Drasner K. Local anesthetic neurotoxicity: clinical injury and strategies that may minimize risk. Reg Anesth Pain Med 2002;27:576-80
37. Yregard L, Cassuto J, Tarnow P, Nilsson U. Influence of local anaesthetics on inflammatory activity postburn. Burns 2003;29:335-41
38. Jonsson A, Cassuto J, Tarnow P, Sinclair R, Bennett A, Tavares IA. Effects of amide local anaesthetics on eicosanoid formation in burned skin. Acta Anaesthesiol Scand 1999;43:618-22
39. Gordon SM, Chuang BP, Wang XM, Hamza MA, Rowan JS, Brahim JS, Dionne RA. The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. Anesth Analg 2008;106:321-7
40. Yndgaard S, Holst P, Bjerre-Jepsen K, Thomsen CB, Struck-mann J, Mogensen T. Subcutaneously versus subfascially administered lidocaine in pain treatment after inguinal her-niotomy. Anesth Analg 1994;79:324-7
41. Beilin B, Shavit Y, Trabekin E, Mordashev B, Mayburd E, Zeidel A, Bessler H. The effects of postoperative pain manage-ment on immune response to surgery. Anesth Analg 2003; 97:822-7
42. Roszkowski MT, Swift JQ, Hargreaves KM. Effect of NSAID administration on tissue levels of immunoreactive prostaglan-din E2, leukotriene B4, and (S)-flurbiprofen following extrac-tion of impacted third molars. Pain 1997;73:339-45