Intra-articular bupivacaine: Potentially chondrotoxic?

British Journal of Anaesthesia

Volumn 102, Issue 4, 2009, Pages 439-441

  Webb, S T ^a   Ghosh, S ^a  

^a PAPWORTH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BUPIVACAINE; LIDOCAINE; ROPIVACAINE;

ARTHROSCOPIC SURGERY; CHONDROLYSIS; CONTINUOUS INFUSION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG SAFETY; EDITORIAL; HUMAN; LOCAL ANESTHESIA; NONHUMAN; POSTOPERATIVE ANALGESIA; PRIORITY JOURNAL; SINGLE DRUG DOSE;

EID: 62549153950     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aep036     Document Type: Editorial

References (21)

1. Katz JA, Kaeding CS, Hill JR, Henthorn TK. The pharmacokinetics of bupivacaine when injected intra-articularly after knee arthroscopy. Anesth Analg 1988; 67: 872-5
2. Sullivan SG, Abbott PJ. Cardiovascular toxicity associated with intraarticular bupivacaine. Anesth Analg 1994; 79: 591-3
3. Ligouri GA, Chimento GF, Borow L, Figgie M. Possible bupivacaine toxicity after intraarticular injection for postarthroscopic analgesia of the knee: implications for the surgical procedure. Anesth Analg 2002; 94: 1010-3
4. Nole R, Munson NM, Fulkerson JP. Bupivacaine and saline effects on articular cartilage. Arthroscopy 1985; 1: 123-7
5. Dogan N, Erdem AF, Erman Z, Kizilkaya M. The effects of bupivacaine and neostigimine on articular cartilage and synovium in the rabbit knee joint. J Int Med Res 2004; 32: 513-9
6. Petty DH, Jazrawi LM, Estrada LS, Andrews JR. Glenonhumeral chrondrolysis after shoulder arthroscopy: case reports and review of the literature. Am J Sports Med 2004; 32: 509-15
7. Hansen BP, Beck CL, Beck EP, Townsley RW. Postarthroscopic glenohumeral chondrolysis. Am J Sports Med 2007; 35: 1628-34
8. Levy JC, Virani NA, Frankle MA, Cuff D, Pupello DR, Hamelin JA. Young patients with shoulder chondrolysis following arthroscopic shoulder surgery treated with total shoulder arthroplasty. J Shoulder Elbow Surg 2008; 17: 380-8
9. Greis PE, Legrand A, Burks RT. Bilateral shoulder chondrolysis following arthroscopy. A report of two cases. J Bone Joint Surg Am 2008; 90: 1338-44
10. Bojescul JA, Wilson G, Taylor DC. Idiopathic chondrolysis of the ankle. Arthroscopy 2005; 21: 224-7
11. Chu CR, Izzo NJ, Papas NE, Fu H. In vitro exposure to bupivacaine 0.5% is cytotoxic to bovine articular chondrocytes. Arthroscopy 2006; 22: 693-9
12. Chu CR, Izzo NJ, Coyle CH, Papas NE, Logar A. The in vitro effects of bupivacaine on articular chondrocytes. J Bone Joint Surg Br 2008; 90: 814-20
13. Karpie JC, Chu CR. Lidocaine exhibits dose- and time-dependent cytotoxic effects on bovine articular chondrocytes in vitro. Am J Sports Med 2007; 35: 1622-7
14. Piper SL, Kim HT. Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes. J Bone Joint Surg Am 2008; 90: 986-91
15. Gommoll AH, Kang RW, Williams JM, Bach BR, Cole BJ. Chondrolysis after continuous intra-articular bupivicaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder. Arthroscopy 2006; 22: 813-9
16. Gommoll AH, Yanke AB, Kang RW, et al. Long-term effects of bupivacaine on cartilage in a rabbit shoulder model. Am J Sports Med 2009; 37: 72-7
17. Dragoo JL, Korotkova T, Kanwar R, Wood B. The effect of local anesthetics administered via pain pump on chondrocyte viability. Am J Sports Med 2008; 36: 1484-8
18. Athwal GS, Shridharani SM, O'Driscoll SW. Osteolysis and arthropathy of the shoulder after use of bioabsorbable knotless suture anchors. A report of four cases. J Bone Joint Surg Am 2006; 88: 1840-45
19. Levine WN, Clark AM Jr, D'Alessandro DF, Yamaguchi K. Chondrolysis following arthroscopic thermal capsulorrhaphy to treat shoulder instability. A report of two cases. J Bone Joint Surg Am 2005; 87: 616-21
20. Leclair A, Gangi A, Lacaze F, et al. Rapid chondrolysis after intra-articular leak of bone cement in treatment of a benign acetabular subchondral cyst: an unusual complication of percutaneous injection of acrylic cement. Skeletal Radiol 2000; 29: 275-8
21. Douw CM, Bulstra SK, Vandenbroucke J, Geesink RG, Vermeulen A. Clinical and pathological changes in the knee after accidental chlorhexidine irrigation during arthroscopy: case report and review of the literature. J Bone Joint Surg Br 1998; 80: 437-40