Statistical optimization of process variables for the production of an anticancer drug (colchicine derivatives) through fermentation: At scale-up level

New Biotechnology

Volumn 28, Issue 1, 2011, Pages 79-85

  Dubey, Kashyap Kumar ^a   Behera, B K ^a  

^a MAHARSHI DAYANAND UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AERATION RATE; ANTICANCER DRUG; BACILLUS MEGATERIUM; COLCHICINE DERIVATIVES; IMPELLER TIP VELOCITY; MEDIUM COMPONENTS; OPERATIONAL FACTORS; PLACKETT-BURMAN; PROCESS VARIABLES; RESPONSE SURFACE METHODOLOGY; SCALE-UP; STATISTICAL OPTIMIZATION; YEAST EXTRACTS;

BACTERIOLOGY; FERMENTATION; GLYCEROL; IMPELLERS; OPTIMIZATION;

FERMENTERS;

COLCHICINE; GLYCEROL; STARCH;

AERATION; ARTICLE; BACILLUS MEGATERIUM; CLINICAL EVALUATION; DRUG DECOMPOSITION; DRUG MANUFACTURE; PH; PLACKETT BURMAN DESIGN; PRIORITY JOURNAL; RESPONSE SURFACE METHOD; TEMPERATURE; YEAST;

AEROBIOSIS; ANTINEOPLASTIC AGENTS; BACILLUS MEGATERIUM; BIOREACTORS; BIOTECHNOLOGY; BIOTRANSFORMATION; COLCHICINE; FERMENTATION; HYDROGEN-ION CONCENTRATION; METHYLATION; MODELS, STATISTICAL; REPRODUCIBILITY OF RESULTS; TEMPERATURE;

BACILLUS MEGATERIUM;

EID: 78650294479     PISSN: 18716784     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbt.2010.07.008     Document Type: Article

References (38)

1. Boye O., Brossi A. Tropolonic colchicine alkaloids and allocongeners. The Alkaloids, Chemistry and Pharmacology 1992, Academic Press. A. Brossi, G. Cordell (Eds.).
2. Brossi A., et al. Colchicine and its analogues: recent findings. Med. Res. Rev. 1988, 8:77-94.
3. Brossi A. Bioactive alkaloids. IV. Results of recent investigations with colchicine and physio stigmine. An Alfred Burger Award Lecture. J. Med. Chem. 1990, 33:2311-2319.
4. Dumont R., et al. A novel synthesis of colchicide and analogues from thiocolchicine and congeners: reevaluation of colchicide as a potential antitumor agent. J. Med. Chem. 1987, 30:732-735.
5. Muzaffar A., et al. Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J. Med. Chem. 1988, 33:567-571.
6. Kerekes P., et al. Synthesis and biological effects of novel thiocolchicine. 3. Evaluation of N-acyldeacteyl thiocolchicine and O-ethyldemethyl thiocolchicine. New synthesis of thiodemecolcine and antileukamic effects of 2-demethyl- and 3-demethylthiocolchicine. J. Med. Chem. 1985, 28:1204-1208.
7. Herbert R.B. The biosynthesis of plant alkaloids and nitrogenous microbial metabolites. Nat. Prod. Rep. 2003, 20:494-508.
8. Poulev A., et al. Regioselective bioconversion of colchicine and thiocolchicine into their corresponding 3-demethyl derivatives. J. Ferment. Bioeng. 1995, 79:33-38.
9. Dubey K.K., et al. Production of demethylated colchicine through microbial transformation and scale-up process development. Process Biochem. 2008, 43:251-257.
10. Dubey K.K., et al. Construction of recombinant Escherichia coli for enhanced bioconversion of colchicine into 3-demethylated colchicine at 70L bioreactor level. Process Biochem. 2010, 10.1016/j.procbio.2010.03.014.
11. Urlacher V.B., Schmid R.D. Protein engineering of the cytochrome P450 monooxygenase from Bacillus megaterium. Methods Enzymol. 2004, 388:208-220.
12. Urlacher V., et al. Microbial P450 enzymes in biotechnology. Appl. Microbiol. Biotechnol. 2004, 64:317-325.
13. Tateishi T., et al. Colchicine biotransformation by human liver microsomes: identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Biochem. Pharmacol. 1997, 53:111-116.
14. Kennedy M., Krouse D. Strategies for improving fermentation medium performance: a review. J. Ind. Microbiol. Biotechnol. 1999, 23:456-475.
15. Khambhaty Y., Mody K. Statistical optimization of medium components for κ-carrageenase production by Pseudomonas elongate. Enzyme Microb. Technol. 2007, 40:813-822.
16. Khanna S., Srivastava A.K. Statistical media optimization studies for growth and PHB production by Ralstonia eutropha. Process Biochem. 2005, 40:2173-2182.
17. Khanna S., Srivastava A.K. Optimization of nutrient feed concentration and addition time for production of poly (β-hydroxybutyrate). Enzyme Microb. Technol. 2006, 39:1145-1151.
18. Qiu-Li W., et al. Optimization of riboflavin production by recombinant Bacillus subtilis RH44 using statistical designs. Appl. Microbiol. Biotechnol. 2007, 76:783-794.
19. Abdel-Fattah Y.R., et al. Improved production of Pseudomonas aeruginosa uricase by optimization of process parameters through statistical experimental designs. Process Biochem. 2005, 40:1707-1714.
20. Plackett L., Burman J.P. The design of optimum multifactorial experiments. Biometrica 1946, 3:305-325.
21. Gheshlaghi R., et al. Medium optimization for hen egg white lysozyme production by recombinant Aspergillus niger using statistical methods. Biotechnol. Bioeng. 2005, 90:754-760.
22. Sarg T.M., et al. Thin-layer chromatographic scanner, spectrophotometric and high performance liquid chromatographic methods for the determination of colchicine. Analyst 1989, 114:575-578.
23. Klein A.E., Davis P.J. Determination of colchicine and colchicine in microbial cultures by high-performance liquid chromatography. Anal. Chem. 1980, 52:2432-2435.
24. Al-Fayyad M., et al. Determination of colchicine content in Colchicum hierosolymitanum and Colchicum tunicatum under cultivation. Nat. Prod. Lett. 2002, 16:395-400.
25. Bodoki E., et al. Fast determination of colchicine by TLC - densitometry from pharmaceutical and vegetable extract. J. Pharm. Biomed. Anal. 2005, 37:971-977.
26. Doran P.M. Bioprocess Engineering Principles 2005, Academic Press.
27. Deming S.N. Quality by design - part 5. Chemtech. 1990, 2:118.
28. Roquemore K.G. Hybrid design for quadratic response surfaces. Technometrics 1976, 18:419-423.
29. Chatterjee P., et al. Biotransformation of the antimelanoma agent betulinic acid by Bacillus megaterium ATCC 13368. Appl. Environ. Microbiol. 2000, 6:3850-3855.
30. Stark J.R., et al. Characterization of α- and β-amylases from Bacillus megaterium. FEMS Microbiol. Lett. 1982, 15:295-298.
31. Vary P.S. Prime time for Bacillus megaterium. Microbiology 1994, 140:1001-1013.
32. Yang Li-Ming., et al. Hydroxylation and glucosidation of ent-16 β hydroxybeyeran-19-oic acid by Bacillus megaterium and Aspergillus niger. Plant Med. 2004, 70:359-363.
33. BM-3 (CYP102) by non-steroidal anti-inflammatory drugs in Bacillus megaterium. Biochem. J. 1996, 1:279-283.
34. Tang Y.F., et al. Biocatalytic preparation of (S)-phenyl glycidyl ether using newly isolated Bacillus megaterium ECU1001. J. Mol. Catal. B: Enzym. 2001, 13:61-68.
35. Khuri A.I. Response Surface: Design and Analyses 1987, Dekker.
36. Sivaramakrishnan S., et al. α-Amylase from microbial sources - an overview on recent developments. Food Technol. Biotechnol. 2006, 44:173-184.
37. Grant C.L., Pramer D. Minor element composition of yeast extract. J. Bacteriol. 1962, 84:869-870.
38. Nakajo, Y. and Sano, H. (2000). Yeast extract composition, yeast for obtaining the same, and process for producing yeast extract composition. U.S. Patent No. 6,344,231.