Biotransformation of the antimelanoma agent betulinic acid by Bacillus megaterium ATCC 13368

Applied and Environmental Microbiology

Volumn 66, Issue 9, 2000, Pages 3850-3855

  Chatterjee, P ^a   Kouzi, S A ^a   Pezzuto, J M ^a   Hamann, M T ^a  

^a UNIVERSITY OF THE PACIFIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETULIC ACID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BACILLUS MEGATERIUM; BACTERIAL METABOLISM; BIOTRANSFORMATION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL SUSPENSION; CYTOTOXICITY; DRUG STRUCTURE; FERMENTATION; MELANOMA CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR OVERHAUSER EFFECT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BACILLUS MEGATERIUM; BIOTRANSFORMATION; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MELANOMA; TRITERPENES; TUMOR CELLS, CULTURED;

BACILLUS MEGATERIUM; BACTERIA (MICROORGANISMS); MAMMALIA; NEGIBACTERIA;

EID: 0033831223     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.66.9.3850-3855.2000     Document Type: Article

References (29)

1. Characterization of cytochrome P-450-dependent steroid hydroxylase system present in Bacillus megaterium
2. Characterization of cytochrome P-450(meg)
3. Studies on the substrate specificity and inducibility of cytochrome P-450(meg)
4. 13C NMR studies of some lupane and taxarane triterpenes
5. Glucosidation of betulinic acid by Cunninghamella species
6. The use of microorganisms for the study of drug metabolism: An update
7. Triterpenoid extractives in the outer bark of Betula lenta (black birch)
8. Microbial transformations: Models of mammalian metabolism and catalysts in synthetic medicinal chemistry
9. Microbial models of mammalian drug metabolism
10. Betulinic acid derivatives: A new class of human immunodeficiency virus type I specific inhibitors with a new mode of action
11. Anti-AIDS agents. 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids
12. Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents
13. Synthesis of betulinic acid derivatives with activity against human melanoma
14. Hydroxylation and glucoside conjugation in the microbial metabolism of the diterpene sclareol
15. Identification of four biliary metabolites of the diterpene sclareol in the laboratory rat
16. Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo
17. DNA polymerase β inhibitors from Tetracera boiviniana
18. Content of betulin and betulinic acid, antitumor agents of Zizyphus species
19. Triterpene derivatives that block the entry of human immunodeficiency virus type I into cells
20. ω-1, ω-2 and ω-3 hydroxylation of long-chain fatty acids, amides and alcohols by a soluble enzyme system from Bacillus megaterium
21. Characterization of a catalytically self-sufficient 119,000-dalton cytochrome P-450 monooxygenase induced by barbiturates in Bacillus megaterium
22. Identification and characterization of two functional domains in cytochrome P-450BM-3, a catalytically self-sufficient monooxygenase induced by barbiturates in Bacillus megaterium
23. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
24. Microbial models of mammalian metabolism
25. Antitumor triterpenes from medicinal plants
26. Cellular and microbial models of investigation of mammalian metabolism of xenobiotics
27. Microbial transformations as a means of preparing mammalian drug metabolites
28. 13C nuclear magnetic resonance of lupane-type triterpenes, lupeol, betulin and betulinic acid