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Volumn 6044 LNBI, Issue , 2010, Pages 263-280

Simultaneous identification of causal genes and dys-regulated pathways in complex diseases

Author keywords

Biological pathway; Complex disease; Copy number variation; Genetic variations; Glioma; Graph theoretic algorithm

Indexed keywords

BIOLOGICAL PATHWAYS; COMPLEX DISEASE; COPY NUMBER VARIATION; GENETIC VARIATION; GLIOMA; GRAPH THEORETIC ALGORITHM;

EID: 78650267786     PISSN: 03029743     EISSN: 16113349     Source Type: Book Series    
DOI: 10.1007/978-3-642-12683-3_17     Document Type: Conference Paper
Times cited : (8)

References (44)
  • 1
    • 70249134919 scopus 로고    scopus 로고
    • Molecular networks as sensors and drivers of common human diseases
    • Schadt, E.E.: Molecular networks as sensors and drivers of common human diseases. Nature 461, 218-223 (2009).
    • (2009) Nature , vol.461 , pp. 218-223
    • Schadt, E.E.1
  • 4
    • 33845545435 scopus 로고    scopus 로고
    • The modular nature of genetic diseases
    • Oti, M., Brunner, H.G.: The modular nature of genetic diseases. Clin. Genet. 71, 1-11 (2007).
    • (2007) Clin. Genet. , vol.71 , pp. 1-11
    • Oti, M.1    Brunner, H.G.2
  • 7
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • Ramaswamy, S., Ross, K.N., Lander, E.S., Golub, T.R.: A molecular signature of metastasis in primary solid tumors. Nat. Genet. 33, 49-54 (2003).
    • (2003) Nat. Genet. , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 8
    • 33646709458 scopus 로고    scopus 로고
    • Gene expression profiling of breast cancer
    • Nagasaki, K., Miki, Y.: Gene expression profiling of breast cancer. Breast Cancer 13, 2-7 (2006).
    • (2006) Breast Cancer , vol.13 , pp. 2-7
    • Nagasaki, K.1    Miki, Y.2
  • 9
    • 48749107434 scopus 로고    scopus 로고
    • Identification of candidate prostate cancer genes through comparative expressionprofiling of seminal vesicle
    • Thompson, M., Lapointe, J., Choi, Y.L., Ong, D.E., Higgins, J.P., Brooks, J.D., Pollack, J.R.: Identification of candidate prostate cancer genes through comparative expressionprofiling of seminal vesicle. Prostate 68, 1248-1256 (2008).
    • (2008) Prostate , vol.68 , pp. 1248-1256
    • Thompson, M.1    Lapointe, J.2    Choi, Y.L.3    Ong, D.E.4    Higgins, J.P.5    Brooks, J.D.6    Pollack, J.R.7
  • 12
  • 13
    • 57149092133 scopus 로고    scopus 로고
    • Inferring pathway activity toward precise disease classification
    • Lee, E., Chuang, H.Y., Kim, J.W., Ideker, T., Lee, D.: Inferring pathway activity toward precise disease classification. PLoS Comput. Biol. 4, e1000217 (2008).
    • (2008) PLoS Comput. Biol. , vol.4
    • Lee, E.1    Chuang, H.Y.2    Kim, J.W.3    Ideker, T.4    Lee, D.5
  • 15
  • 16
    • 41549139527 scopus 로고    scopus 로고
    • Walking the interactome for priorization of candidate genes
    • Kohler, S., Bauer, S., Horn, D., Robinson, P.N.: Walking the interactome for priorization of candidate genes. Am. J. Human Genet. 82, 949-958 (2008).
    • (2008) Am. J. Human Genet. , vol.82 , pp. 949-958
    • Kohler, S.1    Bauer, S.2    Horn, D.3    Robinson, P.N.4
  • 17
    • 84871193073 scopus 로고    scopus 로고
    • A propagation-based algorithm for inferring gene-disease associations
    • LNI
    • Vanunu, O., Sharan, R.: A propagation-based algorithm for inferring gene-disease associations. In: German Conference on Bioinformatics. LNI, vol. 136 (2008).
    • (2008) German Conference on Bioinformatics , vol.136
    • Vanunu, O.1    Sharan, R.2
  • 18
    • 43249114206 scopus 로고    scopus 로고
    • Network-based global inference of human disease
    • Wu, X., Jiang, R., Zhang, M.Q., Li, S.: Network-based global inference of human disease. Mol. Sys. Biol. 4, 189 (2008).
    • (2008) Mol. Sys. Biol. , vol.4 , pp. 189
    • Wu, X.1    Jiang, R.2    Zhang, M.Q.3    Li, S.4
  • 21
    • 34548427938 scopus 로고    scopus 로고
    • Moving toward a system genetics view of disease
    • Sieberts, S.K., Schadt, E.E.: Moving toward a system genetics view of disease. Mamm Genome 18, 389-401 (2007).
    • (2007) Mamm Genome , vol.18 , pp. 389-401
    • Sieberts, S.K.1    Schadt, E.E.2
  • 22
    • 77950836408 scopus 로고    scopus 로고
    • Discovery of regulatory mechanisms by genome-wide from gene expression variation by eQTL analyisis
    • Lonardi, J.Y.C.a.S. (ed.), CRC Press, Boca Raton
    • Huang, Y., Zheng, J., Przytycka, T.: Discovery of regulatory mechanisms by genome-wide from gene expression variation by eQTL analyisis. In: Lonardi, J.Y.C.a.S. (ed.) Biological Data Mining, pp. 205-228. CRC Press, Boca Raton (2009).
    • (2009) Biological Data Mining , pp. 205-228
    • Huang, Y.1    Zheng, J.2    Przytycka, T.3
  • 23
    • 33747880011 scopus 로고    scopus 로고
    • An integrative approach for causal gene identification and gene regulatory pathway inference
    • Tu, Z., Wang, L., Arbeitman, M.N., Chen, T., Sun, F.: An integrative approach for causal gene identification and gene regulatory pathway inference. Bioinformatics 22, e489-e496 (2006).
    • (2006) Bioinformatics , vol.22
    • Tu, Z.1    Wang, L.2    Arbeitman, M.N.3    Chen, T.4    Sun, F.5
  • 24
    • 42949096140 scopus 로고    scopus 로고
    • EQED: An efficient method for interpreting eQTL associations using protein networks
    • Suthram, S., Beyer, A., Karp, R.M., Eldar, Y., Ideker, T.: eQED: an efficient method for interpreting eQTL associations using protein networks. Mol. Syst. Biol. 4, 162 (2008).
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 162
    • Suthram, S.1    Beyer, A.2    Karp, R.M.3    Eldar, Y.4    Ideker, T.5
  • 28
    • 0035793042 scopus 로고    scopus 로고
    • Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection
    • Li, C., Wong, W.H.: Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc. Natl. Acad. Sci. U.S.A. 98, 31-36 (2001).
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 31-36
    • Li, C.1    Wong, W.H.2
  • 38
    • 33846107777 scopus 로고    scopus 로고
    • TRED: A transcriptional regulatory element database, new entries and other development
    • Jiang, C., Xuan, Z., Zhao, F., Zhang, M.Q.: TRED: a transcriptional regulatory element database, new entries and other development. Nucleic Acids Res. 35, D137-D140 (2007).
    • (2007) Nucleic Acids Res. , vol.35
    • Jiang, C.1    Xuan, Z.2    Zhao, F.3    Zhang, M.Q.4
  • 42
    • 33748486517 scopus 로고    scopus 로고
    • AceView: A comprehensive cDNA-supported gene and transcripts annotation
    • 11-14
    • Thierry-Mieg, D., Thierry-Mieg, J.: AceView: a comprehensive cDNA-supported gene and transcripts annotation. Genome Biol. 7(suppl.1), S12 11-14 (2006).
    • (2006) Genome Biol. , vol.7 , Issue.SUPPL. 1
    • Thierry-Mieg, D.1    Thierry-Mieg, J.2
  • 43
    • 0031808435 scopus 로고    scopus 로고
    • GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR
    • Wang, X.Y., Smith, D.I., Liu, W., James, C.D.: GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR. Genomics 49, 448-451 (1998).
    • (1998) Genomics , vol.49 , pp. 448-451
    • Wang, X.Y.1    Smith, D.I.2    Liu, W.3    James, C.D.4
  • 44
    • 0141612789 scopus 로고    scopus 로고
    • FAK signaling in anaplastic astrocytoma and glioblastoma tumors
    • Sudbury, Mass
    • Natarajan, M., Hecker, T.P., Gladson, C.L.: FAK signaling in anaplastic astrocytoma and glioblastoma tumors. Cancer journal (Sudbury, Mass) 9, 126-130 (2003).
    • (2003) Cancer Journal , vol.9 , pp. 126-130
    • Natarajan, M.1    Hecker, T.P.2    Gladson, C.L.3


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