Improved synthesis of (E)-12-nitrooctadec-12-enoic acid, a potent PPARγ activator. development of a "buffer-Free" enzymatic method for hydrolysis of methyl esters

Journal of Organic Chemistry

Volumn 75, Issue 23, 2010, Pages 8311-8314

  Zanoni, Giuseppe ^a   Valli, Matteo ^a   Bendjeddou, Lyamin ^a   Porta, Alessio ^a   Bruno, Paolo ^a   Vidari, Giovanni ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC DRUG; ENZYMATIC CLEAVAGE; ENZYMATIC METHODS; GLUCOSE LEVEL; ISOPROSTANES; METHYL ESTERS; NATURAL PRODUCTS; PHYTOPROSTANES; POTENT ACTIVATORS; SIDE EFFECT;

CYTOLOGY; DRUG INTERACTIONS; ENZYMATIC HYDROLYSIS; ESTERIFICATION; FATTY ACIDS; GLUCOSE;

ESTERS;

10 NITROLINOLEIC ACID; 10 NITROOLEIC ACID; 12 NITROOCTADEC 12 ENOIC ACID; 13 NITROOCTADEC 12 ENOIC ACID; BUFFER; ESTER DERIVATIVE; FATTY ACID DERIVATIVE; METHYL 12 NITROOCTADEC 12 ENOATE; METHYL 13 HYDROXY 12 NITROOCTADECANOATE; METHYL ESTER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CLAISEN REARRANGEMENT; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; STEREOCHEMISTRY;

ESTERS; HYDROLYSIS; HYPOGLYCEMIC AGENTS; LINOLEIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NITRO COMPOUNDS; PPAR GAMMA; TRIFLUOROACETIC ACID;

EID: 78650255849     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo101806m     Document Type: Article

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