Sensitive determination of a pharmaceutical compound and its metabolites in human plasma by ultra-high performance liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 4, 2011, Pages 742-749

  Heinig, K ^a   Wirz, T ^a   Bucheli, F ^a   Monin, V ^a   Gloge, A ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Human plasma; LC MS MS; Microdosing; On line SPE; UHPLC

Indexed keywords

6 BETA HYDROXY CORTISONE; CORTISONE DERIVATIVE; DRUG METABOLITE; FLUDROXYCORTIDE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; PRECIPITATION; PRIORITY JOURNAL; SIGNAL NOISE RATIO; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIMIT OF DETECTION; MICROCHEMISTRY; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; REPRODUCIBILITY OF RESULTS; SOLID PHASE MICROEXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TECHNOLOGY, PHARMACEUTICAL;

EID: 78650252580     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.10.003     Document Type: Article

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