The identification of a nitrosated prodrug of the PDE-5 inhibitor aildenafil in a dietary supplement: A Viagra with a pop

Journal of Pharmaceutical and Biomedical Analysis

Volumn 54, Issue 4, 2011, Pages 735-741

  Venhuis, B J ^a   Zomer, G ^b   Hamzink, M ^b   Meiring, H D ^b   Aubin, Y ^c   de Kaste, D ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b NETHERLANDS VACCINE INSTITUTE   (Netherlands)

^c HEALTH CANADA   (Canada)

Author keywords

Aildenafil prodrug; Liquid chromatography mass spectrometry (LC MS); Nitroso prodenafil; Nuclear magnetic resonance (NMR); Sildenafil analogue

Indexed keywords

AILDENAFIL; CARCINOGEN; ISOSORBIDE DINITRATE; NITRIC OXIDE; NITROSO PRODENAFIL; PHOSPHODIESTERASE V INHIBITOR; PRODRUG; SILDENAFIL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG ISOLATION; INFRARED SPECTROMETRY; LIQUID CHROMATOGRAPHY; NITROSATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; VASODILATATION;

DESIGNER DRUGS; DIETARY SUPPLEMENTS; ERECTILE DYSFUNCTION; HUMANS; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MOLECULAR STRUCTURE; NITRIC OXIDE DONORS; NITROSAMINES; NITROSATION; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PRODRUGS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SULFONES; TANDEM MASS SPECTROMETRY;

EID: 78650244078     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.11.020     Document Type: Article

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