Structure elucidation of a novel synthetic thiono analogue of sildenafil detected in an alleged herbal aphrodisiac

Journal of Pharmaceutical and Biomedical Analysis

Volumn 46, Issue 4, 2008, Pages 814-817

  Venhuis, B J ^a   Zomer, G ^b   de Kaste, D ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b National Vaccine Institute   (Netherlands)

Author keywords

Dietary supplements; Liquid chromatography mass spectrometry (LC MS); Nuclear magnetic resonance (NMR); Sildenafil analogue; Thio homosildenafil

Indexed keywords

APHRODISIAC AGENT; CARBON; N ETHYLPIPERAZINE; PIPERAZINE DERIVATIVE; SILDENAFIL; SULFUR; THIO HOMOSILDENAFIL; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOPHORE; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; INFRARED SPECTROSCOPY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

CHROMATOGRAPHY, LIQUID; DRUG CONTAMINATION; DRUGS, CHINESE HERBAL; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; SULFONES;

EID: 39149089637     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.12.007     Document Type: Article

References (17)

1. Terrett N.K., Bell A.S., Brown D., and Ellis P. Bioorg. Med. Chem. Lett. 6 (1996) 1819-1824
2. Pissarnitski D. Med. Res. Rev. 26 (2006) 369-395
3. P. Ellis, N.K. Terrett, Pfizer Inc. Patent WO94/28902, (1994).
4. U. Niewöhner, M. Es-Sayed, H. Haning, T. Schenke, G. Schmidt, K.H. Schlemmer, E. Bischoff, K. Dembowski, E. Perzborn, Bayer Aktiengesellschaft. Patent WO99/67244, (1999).
5. M.W. Orme, J.S. Sawyer, L.M. Schultze, Lilly ICOS LLC. Patent WO02/098428, (2002).
6. B.J. Venhuis, D.M. Barends, M.E. Zwaagstra, D. de Kaste, Recent developments in counterfeits and imitations of Viagra, Cialis and Levitra, A 2005-2006 update, National Institute for Public Health and the Environment, RIVM Report 370030001, 2007.
7. Reepmeyer J.C., Woodruff J.T., and d'Avignon D.A. J. Pharm. Biomed. Anal. 43 (2007) 1615-1621
8. Wang J., Jiang Y., Wang Y., Zhao X., Cui Y., and Gu J. J. Pharm. Biomed. Anal. 44 (2007) 231-235
9. He Z.J., Zhang K., Jin J., Li N.C., Na Y.Q., Bai W.J., Wang X.F., Zhu J.C., Jiang H., Yuan R.P., Hong B.F., Song T., Yang Y., and Dai D.X. Zhonghua Nan Ke Xue 12 (2006) 1080-1083
10. Palmer M.J., Bell A.S., Fox D.N., and Brown D.G. Curr. Top. Med. Chem. 7 (2007) 405-419
11. Blok-Tip L., Zomer B., Bakker F., Hartog K.D., Hamzink M., Ten Hove J., Vredenbregt M., and De Kaste D. Food Addit. Contam. 21 (2004) 737-748
12. Weishaar R.E., Burrows S.D., Kobylarz D.C., Quade M.M., and Evans D.B. Biochem. Pharmacol. 35 (1986) 787-800
13. http://www.emea.europe.eu
14. Lee H., Hyan Yoo H., Kang M.Y., and Kim D.H. Rapid Comm. Mass Spec. 19 (2005) 1767-1770
15. D.H. Kim, J.H. Kim, K.I. Choi, Y. Kim, G. Nam, J.H. Seo, Korea Institute of Science and Technology. Patent WO 02/102802 A1, (2002).
16. Melnikov P., Corbi P.P., Cuin A., Cavicchioli M., and Guimaraes W.R. J. Pharm. Sci 92 (2003) 2140-2143
17. Sharma R.P., Bala R., Sharma R., and Venugopalan P. J. Mol. Struct. 694 (2004) 229-234