Renal oncocytoma revisited: A clinicopathological study of 109 cases with emphasis on problematic diagnostic features

Histopathology

Volumn 57, Issue 6, 2010, Pages 893-906

  Trpkov, Kiril ^a   Yilmaz, Asli ^a   Uzer, Dina ^a   Dishongh, Kristin M ^b   Quick, Charles M ^b   Bismar, Tarek A ^a   Gokden, Neriman ^b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF ARKANSAS AT LITTLE ROCK   (United States)

Author keywords

Chromophobe; Kidney; Oncocytic neoplasms; Oncocytoma; Renal cell carcinoma

Indexed keywords

ADULT; AGED; ARTICLE; BLEEDING; CANCER DIAGNOSIS; CELL DEATH; CLEAR CELL CARCINOMA; DISEASE COURSE; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYALINE DEGENERATION; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; MITOSIS; ONCOCYTOMA; PRIORITY JOURNAL; RECURRENT DISEASE; RENAL ONCOCYTOMA; SCAR FORMATION;

ADENOMA, OXYPHILIC; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, RENAL CELL; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; KIDNEY; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; NECROSIS; RETROSPECTIVE STUDIES;

EID: 78650237471     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2010.03726.x     Document Type: Article

References (40)

1. Zippel L. Zur Kenntnis Der Oncocyten. Virchows Arch [A] 1942; 308; 360-382.
2. Klein MJ, Valensi QJ. Proximal tubular adenomas of kidney with so- called oncocytic features. A clinicopathological study of 13 cases of a rarely reported neoplasm. Cancer 1976; 38; 906-914.
3. Davis CJ, Mostofi FK, Sesterhenn IA, Ho CK. Renal oncocytoma. Clinicopathological study of 166 patients. J. Urogenital. Pathol. 1991; 1; 41-52.
4. Frydenberg M, Eckstein RP, Saalfield JAAH, Breslin FH, Alexander JH, Roche J. Renal oncocytomas - an Australian experience. Br. J. Urol. 1991; 67; 352-357.
5. Amin MB, Crotty TB, Tickoo SK, Farrow GM. Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am. J. Surg. Pathol. 1997; 21; 1-12.
6. Perez- Ordonez B, Hamed G, Campbell S et al. Renal oncocytoma: a clinicopathologic study of 70 cases. Am. J. Surg. Pathol. 1997; 21; 871-883.
7. Dechet CB, Bostwick DG, Blute ML, Bryant SC, Zincke H. Renal oncocytoma: multifocality, bilateralism, metachronous tumor development and co- existent renal cell carcinoma. J. Urol. 1999; 162; 40-42.
8. Amin MB, Amin MB, Tamboli P et al. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms. An experience of 405 cases. Am. J. Surg. Pathol. 2002; 26; 281-291.
9. Romis L, Cindolo L, Patard JJ et al. Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database. Eur. Urol. 2004; 45; 53-57.
10. Gudbjartsson T, Hardarson S, Petursdottir V, Thoroddson A, Magnusson J, Einarsson GV. Renal oncocytoma: a clinicopathological analysis of 45 consecutive cases. BJU Int. 2005; 96; 1275-1279.
11. Murphy WM, Grignon DJ, Perlman EJ. Oncocytoma. In Murphy WM, Grignon DJ, Perlman EJ. Tumours of the kidney, bladder and related urinary structures. AFIP atlas of tumor pathology. Washington, DC: American Registry of Pathology, 2004; 164-175.
12. Petersen RO, Sesterhenn IA, Davis CJ. Oncocytoma. In Petersen RO, Sesterhenn IA, Davis CJ. Urological pathology, 3rd edn. Philadelphia: Lippincott Williams & Wilkins, 2009; 42-44.
13. Reuter VE, Davis CJ, Moch H. Oncocytoma. In Eble JN, Sauter G, Epstein JI, Sesterhenn IA eds. Neoplasms of the urinary system and male genital organs. Pathology and genetics. World Health Organization classification of neoplasms. Lyon: IARC, 2004; 42-43.
14. Hartwick RW, el- Naggar AK, Ro JY et al. Renal oncocytoma and granular renal cell carcinoma. A comparative clinicopathologic and DNA flow cytometric study. Am. J. Clin. Pathol. 1992; 98; 587-593.
15. Licht MR, Novick AC, Tubbs RR, Klein EA, Levin HS, Streem SB. Renal oncocytoma: clinical and biological correlates. J. Urol. 1993; 150; 1380-1383.
16. Neuzillet Y, Lechevallier E, Andre M, Daniel L, Nahon O, Coulange C. Follow- up of renal oncocytoma diagnosed by percutaneous tumor biopsy. Urology 2005; 66; 1181-1185.
17. Yen T- H, Chen Y, Lin J- L, Ng KF. Renal oncocytoma in Taiwan. Ren. Fail. 2006; 28; 141-147.
18. Arguelles- Salido E, Marcilla- Plaza D, Medina- Lopez R, Congregado Ruiz B, Campoy Martinez P, Cayuela Dominguez A. Renal oncocytoma. Review of our series of 22 patients. Actas Urol. Esp. 2006; 30; 583-590.
19. Hes O, Michal M, Sima R et al. Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical and genetic features. Virchows Arch. 2008; 452; 285-293.
20. Wang Y, Fu Y. Renal oncocytoma: a clinicopathological analysis of thirty- six cases [abstract]. Mod. Pathol. 2008; 21(Suppl. 1); 189A.
21. Fan YH, Chang Y- H, Huang WJS, Chung HJ, Chen KK. Renal oncocytoma: clinical experience of Taipei Veterans General Hospital. J. Chin. Med. Assoc. 2008; 71; 254-258.
22. Leroy X, Moukassa D, Copin MC, Saint F, Mazeman E, Gosselin B. Utility of cytokeratin 7 for distinguishing chromophobe renal carcinoma from renal oncocytoma. Eur. Urol. 2000; 37; 484-487.
23. Mathers ME, Pollock AM, Marsh C, O'Donnell M. Cytokeratin 7: a useful adjunct in the diagnosis of chromophobe renal cell carcinoma. Histopathology 2002; 40; 563-567.
24. Wu SL, Kothari P, Wheeler TM, Reese T, Connelly JH. Cytokeratins 7 and 20 immunoreactivity in chromophobe renal carcinomas and renal oncocytomas. Mod. Pathol. 2002; 15; 712-717.
25. Huo L, Sugimura J, Tretiakova MS et al. C- kit expression in renal oncocytomas and chromophobe renal cell carcinomas. Hum. Pathol. 2005; 36; 262-268.
26. Wang H- Y, Mills SE. KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from granular variant of clear cell renal cell carcinoma. Am. J. Surg. Pathol. 2005; 29; 640-646.
27. Pavlovitch CP, Walther MM, Eyler RA et al. Renal tumors in Birt-Hogg-Dube syndrome. Am. J. Surg. Pathol. 2002; 26; 1542-1552.
28. Crotty TB, Lawrence KM, Moertel CA et al. Cytogenetic analysis of six renal oncocytomas and a chromophobe renal cell carcinoma. Evidence that -Y, -1 may be a characteristic anomaly in renal oncocytomas. Cancer Genet. Cytogenet. 1992; 61; 61-66.
29. Fuzesi L, Gunawan B, Braun S et al. Cytogenetic analysis of 11 renal oncocytomas: further evidence of structural rearrangements of 11q13 as a characteristic chromosomal anomaly. Cancer Genet. Cytogenet. 1998; 107; 1-6.
30. Oxley JD, Sullivan J, Mitchelmore A, Gillatt DA. Metastatic renal oncocytoma. J. Clin. Pathol. 2007; 60; 720-722.
31. Tickoo SK, Reuter VE, Amin MB et al. Renal oncocytosis: a morphologic study of fourteen cases. Am. J. Surg. Pathol. 1999; 23; 1094-1101.
32. Amin MB, Paner GP, Alvaredo- Cabrero I et al. Chromophobe renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 145 cases. Am. J. Surg. Pathol. 2008; 32; 1822-1834.
33. Li G, Barthelemy A, Feng G et al. S100A1: a powerful marker to differentiate chromophobe renal cell carcinoma from renal oncocytoma. Histopathology 2007; 50; 642-647.
34. Brunelli M, Eble JN, Zhang S, Martignoni G, Delahunt B, Cheng L. Eosinophilic and classic chromophobe renal cell carcinoma have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17 and this pattern of genetic abnormality is not present in renal oncocytoma. Mod. Pathol. 2005; 18; 161-169.
35. Schwerdtle RF, Storkel S, Neuhaus C et al. Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma. Cancer Res. 1996; 56; 2927-2930.
36. Lefevre M, Couturiere J, Sibony M et al. Adult papillary renal tumor with oncocytic cells: clinicopathologic, immunohistochemical, and cytogenetic features of 10 cases. Am. J. Surg. Pathol. 2005; 29; 1576-1581.
37. Hes O, Brunelli M, Michal M et al. Oncocytic papillary renal cell carcinoma: a clinicopathologic immunohistochemical, ultrastructural, and interphase cytogenetic study of 12 cases. Ann. Diagn. Pathol. 2006; 10; 133-139.
38. Kunju LP, Wojno K, Wolf JS Jr, Cheng L, Shah RB. Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular features. Hum. Pathol. 2008; 39; 96-101.
39. Masuzawa N, Kishimoto M, Nishimura A, Shichiri Y, Yanagisawa A. Oncocytic renal cell carcinoma having papillotubular growth: rare morphological variant of papillary renal cell carcinoma. Pathol. Int. 2008; 58; 300-305.
40. Medeiros LJ, Palmedo G, Krigman HR, Kovacs G, Beckwith JB. Oncocytoid renal cell carcinoma after neuroblastoma: a report of four cases of a distinct clinicopathologic entity. Am. J. Surg. Pathol. 1999; 23; 772-780.