Chromophobe renal cell carcinoma: Histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 145 cases

American Journal of Surgical Pathology

Volumn 32, Issue 12, 2008, Pages 1822-1834

  Amin, Mahul B ^a,g   Paner, Gladell P ^a   Alvarado Cabrero, Isabel ^e   Young, Andrew N ^b   Stricker, Hans J ^d   Lyles, Robert H ^c   Moch, Holger ^f  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY   (United States)

^d HENRY FORD HOSPITAL   (United States)

^e National Medical Center   (Mexico)

^f UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^g Cedars Sinai Medical Center   (United States)

Author keywords

Chromophobe renal cell carcinoma; Hybrid oncocytic tumor; Kidney; Necrosis; Neoplasms; Prognosis; Renal cell carcinoma; Sarcomatoid change; Tumor grade; Tumor stage

Indexed keywords

ADULT; AGED; ARTICLE; CANCER MORTALITY; CANCER RECURRENCE; CANCER STAGING; CHROMOPHOBE ADENOMA; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; MORPHOMETRICS; PHENOTYPE; PROGNOSIS; TUMOR GROWTH; TUMOR VOLUME; KIDNEY TUMOR; MIDDLE AGED; MORTALITY; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, RENAL CELL; FEMALE; HUMANS; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PHENOTYPE; PROGNOSIS;

EID: 58749106461     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181831e68     Document Type: Article

References (68)

1. Adley BP, Gupta A, Lin F, et al. Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol. 2006;126:79-85.
2. Aizawa S, Suzuki M, Kishi T, et al. Chromophobe renal cell carcinoma: report of 41 cases with immunohistochemical, DNA flow cytometric and cytogenetic analysis. Mod Pathol. 1996;9:74A.
3. Akhtar M, Kardar H, Linjawi T, et al. Chromophobe cell carcinoma of the kidney. A clinicopathologic study of 21 cases. Am J Surg Pathol. 1995;19:1245-1256.
4. Akhtar M, Tulbah A, Kardar AH, et al. Sarcomatoid renal cell carcinoma: the chromophobe connection. Am J Surg Pathol. 1997; 21:1188-1195.
5. Amin MB, Corless CL, Renshaw AA, et al. Papillary (chromophil) renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 62 cases. Am J Surg Pathol. 1997;21:621-635.
6. Amin MB, Crotty TB, Tickoo SK, et al. Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am J Surg Pathol. 1997;21:1-12.
7. Amin MB, Tamboli P, Javidan J, et al. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases. Am J Surg Pathol. 2002;26:281-291.
8. Baba M, Hong SB, Sharma N, et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc Natl Acad Sci USA. 2006;103:15552-15557.
9. Barnabas N, Amin MB, Pindolia K, et al. Mutations in the von Hippel-Lindau (VHL) gene refine differential diagnostic criteria in renal cell carcinoma. J Surg Oncol. 2002;80:52-60.
10. Beck SD, Patel MI, Snyder ME, et al. Effect of papillary and chromophobe cell type on disease-free survival after nephrectomy for renal cell carcinoma. Ann Surg Oncol. 2004;11:71-77.
11. Cheville JC, Lohse CM, Zincke H, et al. Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol. 2003;27:612-624.
12. Cindolo L, de la Taille A, Schips L, et al. Chromophobe renal cell carcinoma: comprehensive analysis of 104 cases from multicenter European database. Urology. 2005;65:681-686.
13. Crotty TB, Farrow GM, Lieber MM. Chromophobe cell renal carcinoma: clinicopathological features of 50 cases. J Urol. 1995;154: 964-967.
14. Darvishian F, Olgac S, Tickoo S, et al. Chromophobe renal cell carcinoma: clinicopathologic study of 146 cases at a single institution. Mod Pathol. 2004;17:147A.
15. Delahunt B, Sika-Paotonu D, Bethwaite PB, et al. Fuhrman grading is not appropriate for chromophobe renal cell carcinoma. Am J Surg Pathol. 2007;31:957-960.
16. de Peralta-Venturina M, Moch H, et al. Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. Am J Surg Pathol. 2001;25:275-284.
17. Frank I, Blute ML, Leibovich BC, et al. Independent validation of the 2002 American Joint Committee on cancer primary tumor classification for renal cell carcinoma using a large, single institution cohort. J Urol. 2005;173:1889-1892.
18. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982;6:655-663.
19. Greene FL, Page DL, Fleming ID, et al. AJCC Cancer Staging Manual. 6th ed. New York, NY: Springer-Verlag; 2002.
20. Gudbjartsson T, Hardarson S, Petursdottir V, et al. Histological subtyping and nuclear grading of renal cell carcinoma and their implications for survival: a retrospective nation-wide study of 629 patients. Eur Urol. 2005;48:593-600.
21. Harik LR, Pashaei S, Humphrey PA, et al. Needle core biopsy of the kidney for mass lesions: a clinicopathologic perspective based on 196 cases. Mod Pathol. 2005;18:144A.
22. Higgins JP, Shinghal R, Gill H, et al. Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am J Pathol. 2003;162:925-932.
23. Junker K, Weirich G, Amin MB, et al. Genetic subtyping of renal cell carcinoma by comparative genomic hybridization. Recent Results Cancer Res. 2003;162:169-175.
24. Kovacs A, Kovacs G. Low chromosome number in chromo-phobe renal cell carcinomas. Genes Chromosomes Cancer. 1992;4: 267-268.
25. Kuehn A, Paner GP, Skinnider BF, et al. Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. Am J Surg Pathol. 2007;31: 1420-1429.
26. Latham B, Dickersin GR, Oliva E. Subtypes of chromophobe cell renal carcinoma: an ultrastructural and histochemical study of 13 cases. Am J Surg Pathol. 1999;23:530-535.
27. Lin BT, Brynes RK, Gelb AB, et al. Cyclin D1 expression in renal carcinomas and oncocytomas: an immunohistochemical study. Mod Pathol. 1998;11:1075-1081.
28. Lindgren V, Paner GP, Omeroglu A, et al. Cytogenetic analysis of a series of 13 renal oncocytomas. J Urol. 2004;171:602-604.
29. Ljungberg B, Alamdari FI, Stenling R, et al. Prognostic significance of the Heidelberg classification of renal cell carcinoma. Eur Urol. 1999;36:565-569.
30. Marusa M, Zavala-Pompa A, Jimenez RE, et al. Macroscopic features of subtypes of adult renal tumors: an appraisal of distinguishing characteristics in 233 cases. Mod Pathol. 2002;13: 3:107A.
31. Mathers ME, Pollock AM, Marsh C, et al. Cytokeratin 7: a useful adjunct in the diagnosis of chromophobe renal cell carcinoma. Histopathology. 2002;40:563-567.
32. Mazal PR, Exner M, Haitel A, et al. Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. Hum Pathol. 2005;36:22-28.
33. Medeiros LJ, Jones EC, Aizawa S, et al. Grading of renal cell carcinoma: Workgroup No. 2. Union Internationale Contre le Cancer and the American Joint Committee on Cancer (AJCC). Cancer. 1997;80:990-991.
34. Meloni AM, Sandberg AA, White RD. -Y,-1 as recurrent anomaly in oncocytoma. Cancer Genet Cytogenet. 1992;61:108-109.
35. Moch H, Gasser T, Amin MB, et al. Prognostic utility of the recently recommended histologic classification and revised TNM staging system of renal cell carcinoma: a Swiss experience with 588 tumors. Cancer. 2000;89:604-614.
36. Onishi T, Oishi Y, Yanada S, et al. Prognostic implications of histological features in patients with chromophobe cell renal carcinoma. BJU Int. 2002;90:529-532.
37. Pan CC, Chen PC, Ho DM. The diagnostic utility of MOC31, BerEP4, RCC marker and CD10 in the classification of renal cell carcinoma and renal oncocytoma: an immunohistochemical analysis of 328 cases. Histopathology. 2004;45:452-459.
38. Paner GP, Alvarado-Cabrero I, Moch H, et al. A novel nuclear grading scheme for chromophobe renal cell carcinoma: prognostic utility and comparison with Fuhrman's nuclear grade. Mod Pathol. 2006;19:154A.
39. Paner GP, Ritchie J, Stewart A, et al. Analysis of observed survival outcomes in histologically-specified renal cell carcinoma (RCC). 1993-1998 cases from the National Cancer Data Base (NCDB). Mod Pathol. 2007;20:168A-169A.
40. Patard JJ, Leray E, Rioux-Leclercq N, et al. Prognostic value of histologic subtypes in renal cell carcinoma: a multicenter experience. J Clin Oncol. 2005;23:2763-2771.
41. Pavlovich CP, Walther MM, Eyler RA, et al. Renal tumors in the Birt-Hogg-Dube syndrome. Am J Surg Pathol. 2002;26: 1542-1552.
42. Pavlovich CP, Grubb RL III, Hurley K, et al. Evaluation and management of renal tumors in the Birt-Hogg-Dube syndrome. J Urol. 2005;173:1482-1486.
43. Peyromaure M, Misrai V, Thiounn N, et al. Chromophobe renal cell carcinoma: analysis of 61 cases. Cancer. 2004;100:1406-1410.
44. Renshaw AA, Henske EP, Loughlin KR, et al. Aggressive variants of chromophobe renal cell carcinoma. Cancer. 1996;78: 1756-1761.
45. Reuter VE, Tickoo S. Adult renal tumors. In: Mills SE, Carter D, Greenson JK, et al, eds. Sternberg's Diagnostic Surgical Pathology. Philadelphia, PA: Lippincott Williams & Wilkins; 2004: 1955-1999.
46. Rocca PC, Brunelli M, Gobbo S, et al. Diagnostic utility of S100A1 expression in renal cell neoplasms: an immunohistochemical and quantitative RT-PCR study. Mod Pathol. 2007;20:722-728.
47. Salama ME, Guru K, Stricker H, et al. pT1 substaging in renal cell carcinoma: validation of the 2002 TNM staging modification of malignant renal epithelial tumors. J Urol. 2005;173:1492-1495.
48. Schuetz AN, Yin-Goen Q, Amin MB, et al. Molecular classification of renal tumors by gene expression profiling. J Mol Diagn. 2005; 7:206-218.
49. Shen SS, Krishna B, Chirala R, et al. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol. 2005;18:933-940.
50. Skinnider BF, Amin MB. An immunohistochemical approach to the differential diagnosis of renal tumors. Semin Diagn Pathol. 2005;22:51-68.
51. Skinnider BF, Folpe AL, Hennigar RA, et al. Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors. Am J Surg Pathol. 2005; 29:747-754.
52. Speicher MR, Schoell B, du Manoir S, et al. Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am J Pathol. 1994;145:356-364.
53. Störkel S, Martignoni G, van den Berg E. Chromophobe renal cell carcinoma. In: Eble JN, Sauter G, Epstein JI, et al, eds. World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of the Urinary System and Male Genital Organs. Lyon, France: IARC Press; 2004:30-32.
54. Störkel S, Steart PV, Drenckhahn D, et al. The human chromophobe cell renal carcinoma: its probable relation to intercalated cells of the collecting duct. Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;56:237-245.
55. Taki A, Nakatani Y, Misugi K, et al. Chromophobe renal cell carcinoma: an immunohistochemical study of 21 Japanese cases. Mod Pathol. 1999;12:310-317.
56. Thoenes W, Störkel S, Rumpelt HJ. Human chromophobe cell renal carcinoma. Virchows Arch B Cell Pathol Incl Mol Pathol. 1985; 48:207-217.
57. Thoenes W, Störkel S, Rumpelt HJ, et al. Chromophobe cell renal carcinoma and its variants-a report on 32 cases. J Pathol. 1988;155: 277-287.
58. Tickoo SK, Amin MB. Discriminant nuclear features of renal oncocytoma and chromophobe renal cell carcinoma. Analysis of their potential utility in the differential diagnosis. Am J Clin Pathol. 1998;110:782-787.
59. Tickoo SK, Amin MB, Linden MD, et al. Antimitochondrial antibody (113-1) in the differential diagnosis of granular renal cell tumors. Am J Surg Pathol. 1997;21:922-930.
60. Tickoo SK, Amin MB, Linden MD, et al. The MIB-1 tumor proliferation index in adult renal epithelial tumors with granular cytoplasm: biologic implications and differential diagnostic potential. Mod Pathol. 1998;11:1115-1121.
61. Tickoo SK, Amin MB, Zarbo RJ. Colloidal iron staining in renal epithelial neoplasms, including chromophobe renal cell carcinoma: emphasis on technique and patterns of staining. Am J Surg Pathol. 1998;22:419-424.
62. Tickoo SK, Reuter VE, Amin MB, et al. Renal oncocytosis: a morphologic study of fourteen cases. Am J Surg Pathol. 1999;23: 1094-1101.
63. Tickoo SK, Lee MW, Eble JN, et al. Ultrastructural observations on mitochondria and microvesicles in renal oncocytoma, chromophobe renal cell carcinoma, and eosinophilic variant of conventional (clear cell) renal cell carcinoma. Am J Surg Pathol. 2000;24: 1247-1256.
64. Weirich G, Glenn G, Junker K, et al. Familial renal oncocytoma: clinicopathological study of 5 families. J Urol. 1998;160:335-340.
65. Weirich G, Junker K, Salles PGO, et al. Comparative genomic hybridization analysis of renal oncocytomas (RO), chromophobe renal cell carcinoma and tumors with hybrid histology-hybrid oncocytic tumors. Mod Pathol. 2002;15:186A.
66. Went P, Dirnhofer S, Salvisberg T, et al. Expression of epithelial cell adhesion molecule (EpCam) in renal epithelial tumors. Am J Surg Pathol. 2005;29:83-88.
67. Young AN, Amin MB, Moreno CS, et al. Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers. Am J Pathol. 2001;158: 1639-1651.
68. Young AN, de Oliveira Salles PG, Lim SD, et al. Beta defensin-1, parvalbumin, and vimentin: a panel of diagnostic immunohisto-chemical markers for renal tumors derived from gene expression profiling studies using cDNA microarrays. Am J Surg Pathol. 2003; 27:199-205.